Daminozide

Catalog No.S4800 Synonyms: Aminozide, DMASA, DIMG, B 995, Alar, Kylar, B-NINE, SADH

For research use only.

Daminozide (Aminozide, DMASA, DIMG, B 995, Alar, Kylar, B-NINE, SADH), a plant growth regulator, selectively inhibits the KDM2/7 JmjC subfamily with IC50 of 1.5±0.7 μM for KDM2A. It is at least 100-fold selective as an inhibitor of the KDM2/7 subfamily over the other demethylase subfamily members tested, with IC50s of 2 μM or less against KDM2A, PHF8, and KIAA1718 and IC50s of 127 μM for KDM3A or greater (mM range) against other demethylases.

Daminozide Chemical Structure

CAS No. 1596-84-5

Purity & Quality Control

Choose Selective Histone Demethylase Inhibitors

Biological Activity

Description Daminozide (Aminozide, DMASA, DIMG, B 995, Alar, Kylar, B-NINE, SADH), a plant growth regulator, selectively inhibits the KDM2/7 JmjC subfamily with IC50 of 1.5±0.7 μM for KDM2A. It is at least 100-fold selective as an inhibitor of the KDM2/7 subfamily over the other demethylase subfamily members tested, with IC50s of 2 μM or less against KDM2A, PHF8, and KIAA1718 and IC50s of 127 μM for KDM3A or greater (mM range) against other demethylases.
Targets
PHF8 [1]
(Cell-free assay)
KDM2A [1]
(Cell-free assay)
0.55 μM 1.5 μM
In vivo In vivo, daminozide is proposed to inhibit 2OG oxygenases involved in gibberellin, and possibly ethylene, biosynthesis in plants[1].

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 32 mg/mL
(199.78 mM)


* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 160.17
Formula

C6H12N2O3

CAS No. 1596-84-5
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CN(C)NC(=O)CCC(=O)O

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03028285 Completed Drug: arginine sodium succinate Peripheral Vascular Disease POLYSAN Scientific & Technological Pharmaceutical Company July 15 2016 Phase 1

(data from https://clinicaltrials.gov, updated on 2021-09-06)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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