Hypoxanthine

Catalog No.S2424

For research use only.

Hypoxanthine, a naturally occurring purine derivative, an intermediate product of uric acid synthesis, formed from adenylic acid and itself a precursor of xanthine.

Hypoxanthine Chemical Structure

CAS No. 68-94-0

Purity & Quality Control

Related Other Products

Biological Activity

Description Hypoxanthine, a naturally occurring purine derivative, an intermediate product of uric acid synthesis, formed from adenylic acid and itself a precursor of xanthine.
In vitro

Hypoxanthine is a naturally occurring purine derivative. It is occasionally found as a constituent of nucleic acids, where it is present in the anticodon of tRNA in the form of its nucleoside inosine. It has a tautomer known as 6-hydroxypurine. Hypoxanthine is a necessary additive in certain cell, bacteria, and parasite cultures as a substrate and nitrogen source. [1] [2]

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 0.4 mg/mL
(2.93 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 136.11
Formula

C5H4N4O

CAS No. 68-94-0
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=NC2=C(N1)C(=O)NC=N2

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02498652 Completed Drug: RDEA3170 2.5 mg|Drug: allopurinol 300 mg Gout Ardea Biosciences Inc. July 28 2015 Phase 2
NCT02187029 Terminated Drug: PF-06743649|Other: Placebo Gout Pfizer July 2014 Phase 1
NCT02170012 Terminated Drug: PF-06743649|Drug: Placebo Healthy Elderly Pfizer July 2014 Phase 1
NCT02151617 Completed Drug: PF-06743649|Drug: Placebo Healthy Pfizer June 2014 Phase 1
NCT01639534 Completed -- Identify the Presence of a Marker of Ischemia/Hypoperfusion of the Brain Via Peripheral Blood|Ischemia/Hypoperfusion of Brain Virginia Commonwealth University March 2011 --

(data from https://clinicaltrials.gov, updated on 2021-09-06)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Hypoxanthine | Hypoxanthine supplier | purchase Hypoxanthine | Hypoxanthine cost | Hypoxanthine manufacturer | order Hypoxanthine | Hypoxanthine distributor