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Guanosine 5'-triphosphate trisodium salt MicroRNA activator

Name: Guanosine 5'-triphosphate trisodium salt
Brand: Selleck Chemicals
SKU: S3084
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S3084

Guanosine 5'-triphosphate (5'-GTP, Guanosine triphosphate, H4GTP) trisodium salt is an enhancer of myogenic cell differentiation in a murine cells. Guanosine 5'-triphosphate trisodium salt up-regulates miRNA (specifically miR133a and miR133b) and myogenic regulator factor and induces human myogenic precursor cells to release exosomes stuffed with guanosine based molecules (mainly guanosine) in the extracellular milieu.

Chemical Structure

Molecular Weight: 589.13

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability

Quality Control

Batch: S308401 Water]100 mg/mL]false]DMSO]Insoluble]false]Ethanol]Insoluble]false Purity: 98.25%

98.25

Related Targets	Epigenetic Reader Domain HDAC JAK Histone Methyltransferase AMPK PKC PARP HIF Histone Acetyltransferase Aurora Kinase Sirtuin PRMT Histone Demethylase EZH1/2 DNA Methyltransferase Pim LSD1 MLL JMJD G9a/GLP NSD FTO PAD SETD SMYD DOT1 COMT WDR5 HNMT SAM MTase

Chemical Information, Storage & Stability

Molecular Weight	589.13	Formula	C₁₀H₁₃N₅Na₃O₁₄P₃	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	36051-31-7	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	5'-GTP trisodium salt, Guanosine triphosphate, H4GTP			Smiles	[Na+].[Na+].[Na+].NC1=NC2=C(N=C[N]2C3OC(CO[P](O)(=O)O[P]([O-])(=O)O[P]([O-])([O-])=O)C(O)C3O)C(=O)N1

Solubility

In vitro
Batch:

Water : 100 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
=	×	×

Dilution Calculator Molecular Weight Calculator

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

References	https://pubmed.ncbi.nlm.nih.gov/29615899/

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Handling Instructions

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