Catalog No.S3845 Synonyms: 20(R)-Panaxadiol
Molecular Weight(MW): 460.73
Panaxadiol is a triterpene sapogenin originally found in species of Panax (ginseng) and exhibits anticancer, cardioprotective, anti-arrhythmic, and antioxidative activities. It inhibits Ca2+ channels, decreasing channel open time and open state probability in vitro and displaying anti-arrhythmic potential.
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|Description||Panaxadiol is a triterpene sapogenin originally found in species of Panax (ginseng) and exhibits anticancer, cardioprotective, anti-arrhythmic, and antioxidative activities. It inhibits Ca2+ channels, decreasing channel open time and open state probability in vitro and displaying anti-arrhythmic potential.|
Panaxadiol enhances the anti-cancer eVects of 5-FU on human colorectal cancer cells through the regulation of cell cycle transition and the induction of apoptotic cells. Panaxadiol inhibits DNA synthesis in a dose-dependent manner with IC50 values ranging from 0.8 to 1.2 µM in SK-HEP-1 cells and HeLa cells. Panaxadiol-treated cells are arrested at G 1/S phase, which coincides well with decreases in Cyclin A-Cdk2 activity, but not in Cyclin E-Cdk2 and Cdc2 activities. The intracellular levels of p21WAF1/CIP1 are significantly and selectively elevated in a dose- and time-dependent manner in panaxadiol-treated HeLa cells.
|In vitro||Ethanol||22 mg/mL (47.75 mM)|
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