Home Transmembrane Transporters Calcium Channel inhibitor Panaxadiol For research use only.

Panaxadiol

Synonyms: 20(R)-Panaxadiol

Panaxadiol (20(R)-Panaxadiol) is a triterpene sapogenin originally found in species of Panax (ginseng) and exhibits anticancer, cardioprotective, anti-arrhythmic, and antioxidative activities. It inhibits Ca2+ channels, decreasing channel open time and open state probability in vitro and displaying anti-arrhythmic potential.

Panaxadiol Chemical Structure

Panaxadiol Chemical Structure

CAS: 19666-76-3

Purity & Quality Control

Batch: S384501 Ethanol] 22 mg/mL] false] DMSO] Insoluble] false] Water] Insoluble] false Purity: 99.39%
99.39

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Biological Activity

Description Panaxadiol (20(R)-Panaxadiol) is a triterpene sapogenin originally found in species of Panax (ginseng) and exhibits anticancer, cardioprotective, anti-arrhythmic, and antioxidative activities. It inhibits Ca2+ channels, decreasing channel open time and open state probability in vitro and displaying anti-arrhythmic potential.
In vitro
In vitro Panaxadiol enhances the anti-cancer eVects of 5-FU on human colorectal cancer cells through the regulation of cell cycle transition and the induction of apoptotic cells[1]. Panaxadiol inhibits DNA synthesis in a dose-dependent manner with IC50 values ranging from 0.8 to 1.2 µM in SK-HEP-1 cells and HeLa cells. Panaxadiol-treated cells are arrested at G 1/S phase, which coincides well with decreases in Cyclin A-Cdk2 activity, but not in Cyclin E-Cdk2 and Cdc2 activities. The intracellular levels of p21WAF1/CIP1 are significantly and selectively elevated in a dose- and time-dependent manner in panaxadiol-treated HeLa cells[2].
Cell Research Cell lines HCT-116
Concentrations 5, 15, or 25 μM
Incubation Time 24 and 48 h
Method

HCT-116 cells are incubated with varying concentrations of 5-FU (5, 10, 20, 30, 50, or 100 μM) and panaxadiol (5, 15, or 25 μM) for 24 and 48 h.

Chemical Information & Solubility

Molecular Weight 460.73 Formula

C30H52O3
CAS No. 19666-76-3 SDF Download Panaxadiol SDF
Smiles CC1(CCCC(O1)(C)C2CCC3(C2C(CC4C3(CCC5C4(CCC(C5(C)C)O)C)C)O)C)C
Storage (From the date of receipt)

In vitro
Batch:

Ethanol : 22 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble


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In vivo
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