Panaxadiol

Catalog No.S3845 Synonyms: 20(R)-Panaxadiol

For research use only.

Panaxadiol (20(R)-Panaxadiol) is a triterpene sapogenin originally found in species of Panax (ginseng) and exhibits anticancer, cardioprotective, anti-arrhythmic, and antioxidative activities. It inhibits Ca2+ channels, decreasing channel open time and open state probability in vitro and displaying anti-arrhythmic potential.

Panaxadiol Chemical Structure

CAS No. 19666-76-3

Purity & Quality Control

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Biological Activity

Description Panaxadiol (20(R)-Panaxadiol) is a triterpene sapogenin originally found in species of Panax (ginseng) and exhibits anticancer, cardioprotective, anti-arrhythmic, and antioxidative activities. It inhibits Ca2+ channels, decreasing channel open time and open state probability in vitro and displaying anti-arrhythmic potential.
In vitro

Panaxadiol enhances the anti-cancer eVects of 5-FU on human colorectal cancer cells through the regulation of cell cycle transition and the induction of apoptotic cells[1]. Panaxadiol inhibits DNA synthesis in a dose-dependent manner with IC50 values ranging from 0.8 to 1.2 µM in SK-HEP-1 cells and HeLa cells. Panaxadiol-treated cells are arrested at G 1/S phase, which coincides well with decreases in Cyclin A-Cdk2 activity, but not in Cyclin E-Cdk2 and Cdc2 activities. The intracellular levels of p21WAF1/CIP1 are significantly and selectively elevated in a dose- and time-dependent manner in panaxadiol-treated HeLa cells[2].

Protocol (from reference)

Cell Research:

[1]

  • Cell lines: HCT-116
  • Concentrations: 5, 15, or 25 μM
  • Incubation Time: 24 and 48 h
  • Method:

    HCT-116 cells are incubated with varying concentrations of 5-FU (5, 10, 20, 30, 50, or 100 μM) and panaxadiol (5, 15, or 25 μM) for 24 and 48 h.

  • (Only for Reference)

Solubility (25°C)

In vitro

Ethanol 22 mg/mL
(47.75 mM)
DMSO Insoluble
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 460.73
Formula

C30H52O3

CAS No. 19666-76-3
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1(CCCC(O1)(C)C2CCC3(C2C(CC4C3(CCC5C4(CCC(C5(C)C)O)C)C)O)C)C

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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