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Panaxadiol Calcium Channel inhibitor

Cat.No.S3845

Panaxadiol (20(R)-Panaxadiol) is a triterpene sapogenin originally found in species of Panax (ginseng) and exhibits anticancer, cardioprotective, anti-arrhythmic, and antioxidative activities. This compound inhibits Ca2+ channels, decreasing channel open time and open state probability in vitro and displaying anti-arrhythmic potential.
Panaxadiol Calcium Channel inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 460.73

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Quality Control

Batch: S384501 Ethanol]22 mg/mL]false]DMSO]Insoluble]false]Water]Insoluble]false Purity: 99.39%
99.39

Solubility

In vitro
Batch:

Ethanol : 22 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Chemical Information, Storage & Stability

Molecular Weight 460.73 Formula

C30H52O3

 Storage (From the date of receipt)
CAS No. 19666-76-3 Download SDF Storage of Stock Solutions

Synonyms 20(R)-Panaxadiol Smiles CC1(CCCC(O1)(C)C2CCC3(C2C(CC4C3(CCC5C4(CCC(C5(C)C)O)C)C)O)C)C

Mechanism of Action

In vitro
Panaxadiol enhances the anti-cancer eVects of 5-FU on human colorectal cancer cells through the regulation of cell cycle transition and the induction of apoptotic cells. This compound inhibits DNA synthesis in a dose-dependent manner with IC50 values ranging from 0.8 to 1.2 µM in SK-HEP-1 cells and HeLa cells. This chemical-treated cells are arrested at G 1/S phase, which coincides well with decreases in Cyclin A-Cdk2 activity, but not in Cyclin E-Cdk2 and Cdc2 activities. The intracellular levels of p21WAF1/CIP1 are significantly and selectively elevated in a dose- and time-dependent manner in this compound-treated HeLa cells.
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