Tannic acid

Catalog No.S3951 Synonyms: Gallotannic acid

For research use only.

Tannic acid (Gallotannic acid), a polyphenolic compound, is a CXCL12/CXCR4 inhibitor with antiangiogenic, anti-inflammatory and antitumor activity.

Tannic acid Chemical Structure

CAS No. 1401-55-4

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Biological Activity

Description Tannic acid (Gallotannic acid), a polyphenolic compound, is a CXCL12/CXCR4 inhibitor with antiangiogenic, anti-inflammatory and antitumor activity.
Targets
CXCR4 [1]
()
In vitro

Tannic acid, at nontoxic concentrations, specifically inhibits CXCL12-induced human monocyte migration (IC50, 7.5 μg/ml) but does not inhibit CCL2-, CCL3-, CCL5-, formylmethionylleucylphenylalanine (fMLP)-, or C5a-induced migration. The compound markedly blocks CXCL12 binding to THP-1 cells (IC50, 0.36 μg/ml). Tannic acid also inhibits CXCL12-induced, but not epidermal growth factor-induced, migration of MDA 231 breast tumor cells. Additionally, 0.5 μg/ml of tannic acid selectively inhibits CXCL12-mediated, but not basic fibroblast growth factor- or endothelial cell growth supplement-mediated, bovine aorta endothelial cell capillary tube formation[1].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
CHO MnPMSpVv[3Srb36gZZN{[Xl? NF\NOVFMcSC4YXz1[ZMh\m:{IIPv[Il2dSCobIXvdoV{[2WrbjCoNVAhfU1rIIXweIFs\SCrbjDPRXRROUJzLYTyZY5{\mWldHXkJGNJVyClZXzsd{whU2liPTCxMlQ3KM7:TT6= NFHtR3g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{W3NVQyPSd-MkO1O|E1OTV:L3G+
CHO NGn0VplHfW6ldHnvckBie3OjeR?= NXKyZnB1eEmFNUCgeoFtfWW|IH\vdkB{d2SrdX2g[ox2d3Knc3PlbY4hMDFyIIXNLUB2eHSja3WgbY4hV0GWUEHCNU11emGwc3\lZ5Rm\CCFSF:gZ4VtdHNuIFnDOVAhRSB{Lk[zNFI4KM7:TT6= NH;LVXA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{W3NVQyPSd-MkO1O|E1OTV:L3G+
CHO NVy1c|BRTnWwY4Tpc44h[XO|YYm= NG\vPFRMcSC4YXz1[ZMh\m:{IIPv[Il2dSCobIXvdoV{[2WrbjCoNVAhfU1rIIXweIFs\SCrbjDPRXRROUJ|LYTyZY5{\mWldHXkJGNJVyClZXzsd{whU2liPTCzMlI{KM7:TT6= NUnWOHNiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO1O|E1OTVpPkKzOVcyPDF3PD;hQi=>
CHO NIX0PWhHfW6ldHnvckBie3OjeR?= NUjpRZR7eEmFNUCgeoFtfWW|IH\vdkB{d2SrdX2g[ox2d3Knc3PlbY4hMDFyIIXNLUB2eHSja3WgbY4hV0GWUEHCN{11emGwc3\lZ5Rm\CCFSF:gZ4VtdHNuIFnDOVAhRSB2LkG2PFY6KM7:TT6= Mni2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN3N{G0NVUoRjJ|NUexOFE2RC:jPh?=
In vivo Given in drinking water, tannic acid enhances the survival rate of mice bearing syngeneic tumors[1].

Protocol (from reference)

Cell Research:[1]
  • Cell lines: THP-1 cells or BAEC cells
  • Concentrations: 0-100 μg/ml
  • Incubation Time: 24 h
  • Method: Freshly isolated human monocytes, THP-1 cells or BAEC cells, are plated into 96-microwell plates at 1 × 105 cells/well in the presence of tannic acid at a final concentration of 100 μg/ml. Cell viability is determined by [3H]thymidine incorporation (THP-1 cells and BAEC cells) or trypan blue exclusion (human monocytes), 24 h after coincubation at 37°C in humidified air with 5% CO2.
  • (Only for Reference)

Solubility (25°C)

In vitro

DMSO 100 mg/mL
(58.78 mM)


* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 1701.2
Formula

C76H52O46

CAS No. 1401-55-4
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=C(C=C(C(=C1O)O)O)C(=O)OC2=CC(=CC(=C2O)O)C(=O)OCC3C(C(C(C(O3)OC(=O)C4=CC(=C(C(=C4)OC(=O)C5=CC(=C(C(=C5)O)O)O)O)O)OC(=O)C6=CC(=C(C(=C6)OC(=O)C7=CC(=C(C(=C7)O)O)O)O)O)OC(=O)C8=CC(=C(C(=C8)OC(=O)C9=CC(=C(C(=C9)O)O)O)O)O)OC(=O)C1=CC(=C(C(=C1)OC(=O)C1=CC(=C(C(=C1)O)O)O)O)O

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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