Tannic acid

For research use only. Not for use in humans.

Catalog No.S3951 Synonyms: Gallotannic acid

Tannic acid Chemical Structure

Molecular Weight(MW): 1701.2

Tannic acid, a polyphenolic compound, is a CXCL12/CXCR4 inhibitor with antiangiogenic, anti-inflammatory and antitumor activity.

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Biological Activity

Description Tannic acid, a polyphenolic compound, is a CXCL12/CXCR4 inhibitor with antiangiogenic, anti-inflammatory and antitumor activity.
CXCR4 [1]
In vitro

Tannic acid, at nontoxic concentrations, specifically inhibits CXCL12-induced human monocyte migration (IC50, 7.5 μg/ml) but does not inhibit CCL2-, CCL3-, CCL5-, formylmethionylleucylphenylalanine (fMLP)-, or C5a-induced migration. The compound markedly blocks CXCL12 binding to THP-1 cells (IC50, 0.36 μg/ml). Tannic acid also inhibits CXCL12-induced, but not epidermal growth factor-induced, migration of MDA 231 breast tumor cells. Additionally, 0.5 μg/ml of tannic acid selectively inhibits CXCL12-mediated, but not basic fibroblast growth factor- or endothelial cell growth supplement-mediated, bovine aorta endothelial cell capillary tube formation[1].

In vivo Given in drinking water, tannic acid enhances the survival rate of mice bearing syngeneic tumors[1].


Cell Research:[1]
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  • Cell lines: THP-1 cells or BAEC cells
  • Concentrations: 0-100 μg/ml
  • Incubation Time: 24 h
  • Method: Freshly isolated human monocytes, THP-1 cells or BAEC cells, are plated into 96-microwell plates at 1 × 105 cells/well in the presence of tannic acid at a final concentration of 100 μg/ml. Cell viability is determined by [3H]thymidine incorporation (THP-1 cells and BAEC cells) or trypan blue exclusion (human monocytes), 24 h after coincubation at 37°C in humidified air with 5% CO2.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (58.78 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 1701.2


CAS No. 1401-55-4
Storage powder
in solvent
Synonyms Gallotannic acid
Smiles OC1=CC(=CC(=C1O)O)C(=O)OC2=C(O)C(=CC(=C2)C(=O)OCC3OC(OC(=O)C4=CC(=C(O)C(=C4)O)OC(=O)C5=CC(=C(O)C(=C5)O)O)C(OC(=O)C6=CC(=C(O)C(=C6)O)OC(=O)C7=CC(=C(O)C(=C7)O)O)C(OC(=O)C8=CC(=C(O)C(=C8)O)OC(=O)C9=CC(=C

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID