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Vindesine sulfate Microtubule Associated inhibitor

Name: Vindesine sulfate
Brand: Selleck Chemicals
SKU: S2440
Availability: InStock
Rating: 5 (2 reviews)

Cat.No.S2440

Vindesine sulfate, a vinca alkaloid derived from Catharanthus roseus, is a potent inhibitor of mitosis with antineoplastic activities. Vindesine binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule and mitotic arrest or cell death.

Chemical Structure

Molecular Weight: 852

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Quality Control

Batch: Purity: 98.60%

98.60

Related Targets	Akt Wnt/beta-catenin PKC HSP ROCK Integrin Bcr-Abl Actin FAK Kinesin
Other Microtubule Associated Inhibitors	Nocodazole Patupilone (Epothilone B) CW069 Combretastatin A4 Lexibulin (CYT997) Epothilone A ABT-751 (E7010) Cucurbitacin B TRx0237 (LMTX) mesylate DM1 (Mertansine)

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (117.37 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 100 mg/mL

Ethanol : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	5mg/ml (5.87mM)	Taking the 1 mL working solution as an example, add 50 μL of 100 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.71mg/ml (0.83mM)	Taking the 1 mL working solution as an example, add 50 μL of 14.2 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	852	Formula	C₄₃H₅₇N₅O₁₁S	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	59917-39-4	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent

Read more about storage stability stock solution CAS number

Mechanism of Action

References	[1] https://pubmed.ncbi.nlm.nih.gov/6248211/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-05-06)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT04043494	RECRUITING	Lymphoblastic Lymphoma, Childhood	University Hospital Muenster	2019-08-23	PHASE3
NCT07159620	RECRUITING	Adult T-cell Leukemia/Lymphoma	The First Affiliated Hospital of Soochow University	2025-09-01	PHASE2
NCT03643276	RECRUITING	Acute Lymphoblastic Leukemia, Pediatric	Martin Schrappe	2018-07-15	PHASE3
NCT06918015	NOT_YET_RECRUITING	BTK Inhibitors; Follicular Lymphoma; Immunochemotherapy	Zhejiang Cancer Hospital	2025-05-01	PHASE2
NCT03206671	ACTIVE_NOT_RECRUITING	Mature B-cell Non-Hodgkin Lymphoma	University Hospital Muenster	2017-08-03	PHASE3
NCT07004075	NOT_YET_RECRUITING	Low-grade Glioma; Pediatric Low-grade Gliomas; pLGG With BRAF Alteration	Shanghai Fosun Pharmaceutical Industrial Development Co. Ltd.	2025-06-30	PHASE3

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Handling Instructions

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