Home Immunology & Inflammation Immunology & Inflammation related chemical Thymol

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Thymol Immunology & Inflammation related chemical

Cat.No.S5157

Thymol (2-isopropyl-5-methylphenol, IPMP), a naturally occurring monocyclic phenolic compound derived from Thymus vulgaris (Lamiaceae), has been reported to exhibit anti-inflammatory property in vivo and vitro.
Thymol Immunology & Inflammation related chemical Chemical Structure

Chemical Structure

Molecular Weight: 150.22

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Quality Control

Batch: S515701 DMSO]30 mg/mL]false]]]false]]]false Purity: 99.94%
99.94

Solubility

In vitro
Batch:

DMSO : 30 mg/mL (199.7 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Chemical Information, Storage & Stability

Molecular Weight 150.22 Formula

C10H14O

 Storage (From the date of receipt)
CAS No. 89-83-8 Download SDF Storage of Stock Solutions

Synonyms 2-isopropyl-5-methylphenol, IPMP Smiles CC1=CC(=C(C=C1)C(C)C)O

Mechanism of Action

In vitro
Thymol inhibits LPS-induced TNF-α, IL-6 and IL-1β production in BALF. Furthermore, this compound significantly reduces the MPO activity, MDA content, lung wet/dry weight ratio and histopathological changes induced by LPS. In addition, it inhibits LPS-induced NF-κB signaling pathway and up-regulates the expression of Nrf2 and HO-1.
In vivo
Thymol has been reported to protect mice against high-fat diet (HFD) induced type 2 diabetes. This compound alleviates LPS-induced lung inflammation in mice.
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02202304 Withdrawn
Periodontal Disease|Caries
Rosa Moreno Lopez|Ivoclar Vivadent AG|University of Aberdeen
 September 10 2017 Phase 4

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