Quercetin Dihydrate

For research use only.

Catalog No.S2347 Synonyms: Sophoretin

7 publications

Quercetin Dihydrate Chemical Structure

CAS No. 6151-25-3

Quercetin (Sophoretin), a polyphenolic flavonoid found in a wide variety of plant-based foods, such as apples, onions, berries, and red wine, is utilized in many different cultures for their nervous system and anticancer effects. Quercetin (dihydrate), a natural flavonoid, is a stimulator of recombinant SIRT1 and a PI3K inhibitor with IC50s of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively.

Size Price Stock Quantity  
10mM (1mL in DMSO) RMB 900.35 In stock
RMB 718.85 In stock
RMB 1207.97 In stock
RMB 2195.47 In stock
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Selleck's Quercetin Dihydrate has been cited by 7 publications

1 Customer Review

  • After starved in serum-free medium for 24h,A549 cells incubated with the indicated concentrations of Quercetin for 3h,followed by 20-minute stimolation of 100ng/ml EGF.

    2011 Quercetin Dihydrate purchased from Selleck.

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Biological Activity

Description Quercetin (Sophoretin), a polyphenolic flavonoid found in a wide variety of plant-based foods, such as apples, onions, berries, and red wine, is utilized in many different cultures for their nervous system and anticancer effects. Quercetin (dihydrate), a natural flavonoid, is a stimulator of recombinant SIRT1 and a PI3K inhibitor with IC50s of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively.
Targets
SIRT1 [3]
()
PI3Kγ [3]
(Cell-free assay)
PI3Kδ [3]
(Cell-free assay)
PI3Kβ [3]
(Cell-free assay)
2.4 μM 3.0 μM 5.4 μM
In vitro

Quercetin, a polyphenolic flavonoid found in a wide variety of plant-based foods, such as apples, onions, berries, and red wine, is utilized in many different cultures for their nervous system and anticancer effects. The pharmacological activities of quercetin that modulate antioxidation/oxidation/kinase-signaling pathways might be differentially elicited in neurons compared with malignant cells, ultimately promoting cell survival or death in a cell type- and metabolism-specific manner. Whereas the broad antioxidation and anti-inflammatory activities of quercetin are important for neuronal survival, the oxidative, kinase- and cell cycle-inhibitory, apoptosis-inducing effects of quercetin are essential for its anticancer effects. [1]

In vivo

LD50: Mice 159mg/kg (i.g.) [2]

Protocol

Solubility (25°C)

In vitro DMSO 67 mg/mL (198.06 mM)
Ethanol 21 mg/mL (62.08 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 338.27
Formula

C15H10O7.2H2O

CAS No. 6151-25-3
Storage powder
in solvent
Synonyms Sophoretin
Smiles C1=CC(=C(C=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O)O.O.O

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03989271 Recruiting Drug: Quercetin Chronic Obstructive Pulmonary Disease Temple University|National Institutes of Health (NIH)|Quercegen Pharmaceuticals|National Center for Complementary and Integrative Health (NCCIH) October 1 2019 Phase 1|Phase 2
NCT01708278 Completed Drug: Quercetin|Other: Placebo - sugar chew Chronic Obstructive Pulmonary Disease University of Michigan|National Institutes of Health (NIH)|Quercegen Pharmaceuticals|National Center for Complementary and Integrative Health (NCCIH) February 2014 Phase 1
NCT01720147 Recruiting Drug: Quercetin (dietary supplement) Fanconi Anemia Children''s Hospital Medical Center Cincinnati|Food and Drug Administration (FDA) July 2012 Phase 1
NCT01438320 Completed Dietary Supplement: Quercetin Chronic Hepatitis C University of California Los Angeles|American Association for Cancer Research|Tower Cancer Research Foundation|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) July 2011 Phase 1

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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PI3K Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID