Catalog No.S3929 Synonyms: 4',7-Dihydroxyflavanone
Molecular Weight(MW): 256.25
Liquiritigenin, the most active estrogenic compound from the root of Glycyrrhizae uralensis Fisch, selectively binds to ERβ with an IC50 value of 7.5 μM and activates multiple ER regulatory elements and native target genes with Erβ but not ERα.
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Choose Selective Estrogen/progestogen Receptor Inhibitors
|Description||Liquiritigenin, the most active estrogenic compound from the root of Glycyrrhizae uralensis Fisch, selectively binds to ERβ with an IC50 value of 7.5 μM and activates multiple ER regulatory elements and native target genes with Erβ but not ERα.|
Liquiritigenin-treated murine osteoblastic MC3T3-E1 cells shows an increased alkaline phosphatase activity and enhances phosphorylation of Smad1/5 compared with untreated cells. Moreover, liquiritigenin inhibits osteoclast differentiation, its bone-resorption activity through slightly decreases the phosphorylation of extracellular signal-regulated kinase, c-Jun N-terminal kinase, and inhibitor of nuclear factor kappa B-α ; however, the phosphorylation of Akt and p38 slightly increase in bone marrow-derived osteoclasts. The expression levels of the osteoclast marker proteins nuclear factor of activated T-cell cytoplasmic-1, Src, and cathepsin K diminish. Liquiritigenin is shown to exert the following pharmacological effects: increased cell growth, increased alkaline phosphatase activity, promotion of collagen synthesis, and the mineralization of osteoblastic MC3T3-E1 cells. Liquiritigenin inhibits serum-induced HIF-1α and VEGF expression via the AKT/mTOR-p70S6K signaling pathway in HeLa cells.
|In vivo||Liquiritigenin inhibits the growth of tumors in nude mice originating from human cervical cancer cell line HeLa cells, and reduces angiogenesis in a dose dependent manner. Liquiritigenin effectively reduces the levels of pro-inflammatory cytokines and the expressions of p-p65NF-κB and p-IκBα. Furthermore, liquiritigenin preconditioning could down-regulate the immobility time in tail suspension test (TST), forced swimming test (FST) and up-regulate BDNF and TrkB contents in hippocampus. Thus, liquiritigenin has antidepressant activity that might be attributed to its anti-inflammatory property and BDNF/TrkB signaling pathway.|
|In vitro||DMSO||51 mg/mL (199.02 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT01199250||Not yet recruiting||Other: Laboratory Biomarker Analysis||Lynch Syndrome|Recurrent Uterine Corpus Carcinoma|Stage I Uterine Corpus Cancer|Stage II Uterine Corpus Cancer|Stage III Uterine Corpus Cancer|Stage IV Uterine Corpus Cancer||Gynecologic Oncology Group|National Cancer Institute (NCI)||January 2100||--|
|NCT02442752||Suspended||Drug: Dexlansoprazole||Pediatric Gastroesophageal Reflux Disease||Takeda||June 15 2025||Phase 1|
|NCT03643887||Not yet recruiting||Drug: FMT Capsule DE|Drug: Placebo oral capsule||Clostridium Difficile Infection||University of Wisconsin Madison||September 1 2022||Phase 2|
|NCT03986086||Not yet recruiting||Drug: MPH966|Drug: Placebo||Hematologic Malignancy||Nelson Chao|Mereo BioPharma|National Center for Advancing Translational Science (NCATS)|Duke University||September 2021||Phase 1|Phase 2|
|NCT00424866||Not yet recruiting||Drug: FGF-1|Drug: Placebo||Peripheral Arterial Disease|Stenosis|Intermittent Claudication||CardioVascular BioTherapeutics Inc.||December 2020||Phase 1|Phase 2|
|NCT03086525||Not yet recruiting||Other: Diagnosis/Prognosis||Musculoskeletal Pain||University of Malaga||December 2020||--|
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