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Flavone Apoptosis related chemical

Name: Flavone
Brand: Selleck Chemicals
SKU: S3967
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S3967

Flavone (2-Phenylchromone, 2-Phenyl-4-chromone, 2-Phenyl-4-benzopyron), a class of flavonoids, mainly found in spices and red or purple plant foods with antioxidant, anti-proliferative, anti-tumor, anti-microbial, estrogenic, acetyl cholinesterase, anti-inflammatory activities and are also used in cancer, cardiovascular disease, neurodegenerative disorders etc.

Chemical Structure

Molecular Weight: 222.24

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability

Quality Control

Batch: S396701 DMSO]44 mg/mL]false]]]false]]]false Purity: 99.86%

99.86

Related Targets	Ras STAT TNF-alpha Bcl-2 Caspase PD-1/PD-L1 Ferroptosis p53 RIP kinase c-RET MDM2/MDMX Myc IAP OXPHOS PERK Thymidylate Synthase FKBP Heme Oxygenase PFKFB PKD Survivin Pyroptosis ASK Bcl-6 Nur77 DAPK TRADD cytohesin TACE Cuproptosis
Related Products	Importazole Genipin Plumbagin 6-Gingerol Crocin Colcemid Euphorbia factor L3 Sophoridine Pomolic acid Protocatechuic acid Bisdemethoxycurcumin (BDMC)

Chemical Information, Storage & Stability

Molecular Weight	222.24	Formula	C₁₅H₁₀O₂	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	525-82-6	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	2-Phenylchromone, 2-Phenyl-4-chromone, 2-Phenyl-4-benzopyron			Smiles	C1=CC=C(C=C1)C2=CC(=O)C3=CC=CC=C3O2

Solubility

In vitro
Batch:

DMSO : 44 mg/mL ( (197.98 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
=	×	×

Dilution Calculator Molecular Weight Calculator

In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	2.200mg/ml (9.90mM)	Taking the 1 mL working solution as an example, add 50 μL of 44 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

In vitro	Flavone is found to reduce cell proliferation in HT-29 cells with an EC50 value of 54.8 ± 1.3 μm and to potently induce differentiation as well as apoptosis. The effects of flavone in HT-29 cells are associated with changed mRNA levels of cell-cycle- and apoptosis-related genes including cyclooxygenase-2 (COX-2), nuclear transcription factor κB (NF-κB), and bcl-XL. Moreover, flavone displays a high selectivity for the induction of apoptosis and of growth inhibition only in the transformed colonocytes^[1].
In vivo	In vivo anti-tumor study indicates that flavone exhibits ability to inhibit tumor formation elicited by s.c. injection of COLO205 cells in nude mice. Apoptotic cells and an increase in p21, but not p53, protein are observed in tumor tissues derived from flavone-treated group. Flavone has been shown to accumulate in intestinal cells suggesting the potential application of flavone in treatment of colorectal carcinoma^[2].
References	https://pubmed.ncbi.nlm.nih.gov/10919656/ https://pubmed.ncbi.nlm.nih.gov/15289867/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT06236360	Recruiting	Melanoma Stage Iv\|Metastatic Melanoma	University Hospital Rijeka	December 21 2023	Not Applicable

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