Flavone

Catalog No.S3967 Synonyms: 2-Phenylchromone, 2-Phenyl-4-chromone, 2-Phenyl-4-benzopyron

For research use only.

Flavone (2-Phenylchromone, 2-Phenyl-4-chromone, 2-Phenyl-4-benzopyron), a class of flavonoids, mainly found in spices and red or purple plant foods with antioxidant, anti-proliferative, anti-tumor, anti-microbial, estrogenic, acetyl cholinesterase, anti-inflammatory activities and are also used in cancer, cardiovascular disease, neurodegenerative disorders etc.

Flavone Chemical Structure

CAS No. 525-82-6

Selleck's Flavone has been cited by 1 Publication

Purity & Quality Control

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Biological Activity

Description Flavone (2-Phenylchromone, 2-Phenyl-4-chromone, 2-Phenyl-4-benzopyron), a class of flavonoids, mainly found in spices and red or purple plant foods with antioxidant, anti-proliferative, anti-tumor, anti-microbial, estrogenic, acetyl cholinesterase, anti-inflammatory activities and are also used in cancer, cardiovascular disease, neurodegenerative disorders etc.
In vitro

Flavone is found to reduce cell proliferation in HT-29 cells with an EC50 value of 54.8 ± 1.3 μm and to potently induce differentiation as well as apoptosis. The effects of flavone in HT-29 cells are associated with changed mRNA levels of cell-cycle- and apoptosis-related genes including cyclooxygenase-2 (COX-2), nuclear transcription factor κB (NF-κB), and bcl-XL. Moreover, flavone displays a high selectivity for the induction of apoptosis and of growth inhibition only in the transformed colonocytes[1].

In vivo In vivo anti-tumor study indicates that flavone exhibits ability to inhibit tumor formation elicited by s.c. injection of COLO205 cells in nude mice. Apoptotic cells and an increase in p21, but not p53, protein are observed in tumor tissues derived from flavone-treated group. Flavone has been shown to accumulate in intestinal cells suggesting the potential application of flavone in treatment of colorectal carcinoma[2].

Protocol (from reference)

Cell Research:

[1]

  • Cell lines: HT-29 Cells
  • Concentrations: 1-1000 μM
  • Incubation Time: 72 h
  • Method:

    Cells (5 × 103 per well) are incubated for 72 h with medium alone (control) or containing the compounds at various concentrations and cell numbers are determined subsequently using SYTOX-Green nucleic acid stain.

Animal Research:

[2]

  • Animal Models: Male BALB/c nu/nu mice (Tumor-bearing mice injected COLO205 cells s.c.)
  • Dosages: 10 and 20 mg/kg
  • Administration: i.p.

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 222.24
Formula

C15H10O2

CAS No. 525-82-6
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=CC=C(C=C1)C2=CC(=O)C3=CC=CC=C3O2

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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