Cucurbitacin IIb

For research use only.

Catalog No.S0949 Synonyms: CuIIb, Dihydrocucurbitacin F, 25-deacetyl hemslecin A

Cucurbitacin IIb Chemical Structure

CAS No. 50298-90-3

Cucurbitacin IIb (CuIIb, Dihydrocucurbitacin F, 25-deacetyl hemslecin A) inhibits phosphorylation of STAT3, JNK and Erk1/2, enhances the phosphorylation of IκB and NF-κB, blocks nuclear translocation of NF-κB and decreases mRNA levels of IκBα and TNF-α. Cucurbitacin IIb exhibits anti-inflammatory activity and induces apoptosis. Cucurbitacin IIb is isolated from Hemsleya amabilis.

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Biological Activity

Description Cucurbitacin IIb (CuIIb, Dihydrocucurbitacin F, 25-deacetyl hemslecin A) inhibits phosphorylation of STAT3, JNK and Erk1/2, enhances the phosphorylation of IκB and NF-κB, blocks nuclear translocation of NF-κB and decreases mRNA levels of IκBα and TNF-α. Cucurbitacin IIb exhibits anti-inflammatory activity and induces apoptosis. Cucurbitacin IIb is isolated from Hemsleya amabilis.
Targets
STAT3 [1]
()
JNK [1]
()
ERK1/2 [1]
()
IκBα [1]
()
NF-κB [1]
()

Protocol

Solubility (25°C)

Chemical Information

Molecular Weight 520.70
Formula

C30H48O7

CAS No. 50298-90-3
Storage powder
in solvent
Synonyms CuIIb, Dihydrocucurbitacin F, 25-deacetyl hemslecin A
Smiles CC1(C(C(CC2C1=CCC3C2(C(=O)CC4(C3(CC(C4C(C)(C(=O)CCC(C)(C)O)O)O)C)C)C)O)O)C

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID