Home Immunology & Inflammation TNF-alpha inhibitor Mulberroside A

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Mulberroside A TNF-alpha inhibitor

Cat.No.S9075

Mulberroside A, isolated from the ethanol extract of Morus alba roots, is widely employed as an active ingredient in cosmetic products due to its anti-tyrosinase and anti-oxidant activities. This compound decreases the expressions of TNF-α, IL-1β and IL-6 and inhibits the activation of NALP3, caspase-1 and NF-κB and the phosphorylation of ERK, JNK and p38.
Mulberroside A TNF-alpha inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 568.52

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Quality Control

Batch: Purity: 99.92%
99.92

Solubility

In vitro
Batch:

DMSO : 10 mg/mL (17.58 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Chemical Information, Storage & Stability

Molecular Weight 568.52 Formula

C26H32O14

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 102841-42-9 -- Storage of Stock Solutions

Synonyms N/A Smiles C1=CC(=C(C=C1OC2C(C(C(C(O2)CO)O)O)O)O)C=CC3=CC(=CC(=C3)OC4C(C(C(C(O4)CO)O)O)O)O

Mechanism of Action

Targets/IC50/Ki
TNF-α
IL-1β
IL-6
NALP3
Caspase-1
NF-κB
ERK
JNK
p38
In vitro

但其中“Mulberroside A”重复出现了很多次。我希望只保留它第一次出现的地方，其他出现的地方改为用代词或类似this compound/this chemical（需要注意这个东西是不是chemical）的词替换，注意保持语义语法正确。一般来说，紧跟在this compound后面的小括号内的词是它的别名，也需要整个替换掉。其他地方不要修改。只返回给我修改后的段落，不加任何话语。
In vivo

但其中“Mulberroside A”重复出现了很多次。我希望只保留它第一次出现的地方，其他出现的地方改为用代词或类似this compound/this chemical（需要注意这个东西是不是chemical）的词替换，注意保持语义语法正确。一般来说，紧跟在this compound后面的小括号内的词是它的别名，也需要整个替换掉。其他地方不要修改。只返回给我修改后的段落，不加任何话语。
References

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