Muscone

Catalog No.S3871 Synonyms: 3-Methylcyclopentadecanone, Methylexaltone

Muscone Chemical Structure

Molecular Weight(MW): 238.41

Muscone, a flavouring ingredient, is an organic compound that is the primary contributor to the odor of musk and also a potent anti-inflammatory agent.

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Biological Activity

Description Muscone, a flavouring ingredient, is an organic compound that is the primary contributor to the odor of musk and also a potent anti-inflammatory agent.
In vitro

Muscone induces CYP1A2 and CYP3A4 expression in liver cells in vitro and in vivo[1]. Muscone protects PC12 cells against glutamate-induced apoptosis by attenuating ROS generation and Ca2+ influx, via NR1 and CaMKII-depended ASK-1/JNK/p38 signaling pathways[2]. Muscone could promote bone marrow-derived mesenchymal stem cells (BMSCs) migration and proliferation[3].

In vivo Muscone exhibits liver toxicity in Kunming mice at concentrations higher than 50 mg/kg[1]. It exerts potent neuroprotective activities on cerebral ischemia[2]. Muscone could accelerate the migration of BMSCs to the injured area in vivo[3].

Protocol

Cell Research:[2]
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  • Cell lines: PC12 cells
  • Concentrations: 0.1, 1, 10 μM
  • Incubation Time: 1 h
  • Method: PC12 cells are seeded in 96-well culture plates at an approximate density of 1×105 cells per well and maintained in a CO2 incubator at 37 ℃ overnight. At the end of indicated treatment, MTT is added to the medium and incubated for another 4 h at 37℃. After the removal of the culture medium, the insoluble dark blue formazan crystal is dissolved with 150 μL DMSO. The absorbance (A) is measured at 490 nm with a microplate reader. Cell viability is expressed as a percentage with the control group as 100%.
    (Only for Reference)

Solubility (25°C)

Chemical Information

Molecular Weight 238.41
Formula

C16H30O

CAS No. 541-91-3
Storage powder
in solvent
Synonyms 3-Methylcyclopentadecanone, Methylexaltone

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID