Dehydroevodiamine hydrochloride

Dehydroevodiamine (DHE), a major phytochemical in fruits of Evodia rutaecarpa, can inhibit AChE. It has hypotensive and neuroprotective effects and modulates nitric oxide production.

Dehydroevodiamine hydrochloride Chemical Structure

Dehydroevodiamine hydrochloride Chemical Structure

CAS: 111664-82-5

Purity & Quality Control

Batch: S382001 DMSO] 37 mg/mL] false] ] ] false] ] ] false Purity: 99.94%
99.94

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Biological Activity

Description Dehydroevodiamine (DHE), a major phytochemical in fruits of Evodia rutaecarpa, can inhibit AChE. It has hypotensive and neuroprotective effects and modulates nitric oxide production.
Targets
AChE [2]
In vitro
In vitro Dehydroevodiamine·HCl (DHED) treatment significantly recovers the decreases in the levels of neural cell adhesion molecule (NCAM) proteins caused by stress and the decreases in cell viability[1]. It decreases intracellular calcium levels in primary cortical neurons[2].
Cell Research Cell lines primary cortical neurons
Concentrations 0.5 and 1 µM
Incubation Time 4 h
Method Cells are cultured in a specified medium for neurons (neurobasal medium supplemented with B27 and penicillin-streptomycin (100 U/ml/100 mg/ml) at 37℃ and 5% CO2 and plated at a density of 5×104 cells/well on Deckgläser cover glasses coated with PLL (1 mg/ml) in the 12 well plates. Experiments are performed on 10-day cultures. After DHED (0.5 and 1 µM) and fluoxetine (0.5 µM) treatment for 4 hr, staurosporin (1 µM) are added for 1 hr.
In Vivo
In vivo Dehydroevodiamine·HCl (DHED) can improve stress-induced memory impairments and depression-like behaviors[1]. DHED significantly improves learning and memory in the Aβ1-42-infused rat model. Antiamnestic effects of DHED occur through an improvement of learning and memory and an inhibition of neuronal dysfunction in a scopolamine-induced amnesic rat model. Furthermore, Dehydroevodiamine·HCl (DHED) has hypotensive and neuroprotective effects and modulates nitric oxide production[2].
Animal Research Animal Models male Wistar rats
Dosages 10 mg/kg/day
Administration p.o.

Chemical Information & Solubility

Molecular Weight 337.8 Formula

C19H15N3O.HCl

CAS No. 111664-82-5 SDF Download Dehydroevodiamine hydrochloride SDF
Smiles CN1C2=CC=CC=C2C(=O)N3C1=C4C(=C5C=CC=CC5=N4)CC3.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 37 mg/mL ( (109.53 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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