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Squalene Fungal chemical

Name: Squalene
Brand: Selleck Chemicals
SKU: S4862
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S4862

Squalene (Spinacene, Supraene, trans-Squalene), a naturally occurring substance found in plants, animals and humans, is a component of some adjuvants that is added to vaccines to enhance the immune response.

Chemical Structure

Molecular Weight: 410.72

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Quality Control

Batch: S486201 Ethanol]100 mg/mL]false]DMSO]Insoluble]false]Water]Insoluble]false Purity: 98%

Cited in Nature Medicine for its top-tier quality
COA
SDS/MSDS
Datasheet

Related Targets	Integrase Bacterial Antibiotics Anti-infection Antiviral COVID-19 Parasite Reverse Transcriptase HIV HCV Protease
Other Fungal Inhibitors	Cycloheximide Tolnaftate Manogepix (E1210) Amorolfine HCl Isavuconazole Juglone Bifonazole Thimerosal Pseudolaric Acid B Butylparaben

Solubility

In vitro
Batch:

Ethanol : 100 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Clear solution	5%DMSO 1 95 %Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.71mg/ml (1.73mM)	Taking the 1 mL working solution as an example, add 50 μL of 14.2 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	2.5mg/ml (6.09mM)	Taking the 1 mL working solution as an example, add 50 μL of 50 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	410.72	Formula	C₃₀H₅₀	Storage (From the date of receipt)	2 years -20°C liquid
CAS No.	111-02-4	--		Storage (From the date of receipt)	2 years -20°C liquid

Read more about storage stability stock solution CAS number

Mechanism of Action

In vitro	Squalene is a triterpene that is an intermediate in the cholesterol biosynthesis pathway. In vitro experimental evidence indicates that this compound is a highly effective oxygen-scavenging agent and possesses antioxidant properties.
In vivo	Squalene appears to be critical in reducing free radical oxidative damage to the skin. It can effectively inhibit chemically induced skin tumorigenesis in rodents.
References	[1] https://pubmed.ncbi.nlm.nih.gov/19169201/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2022-11-17)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT05035680	WITHDRAWN	Influenza	Gates Medical Research Institute	2022-07-14	PHASE1
NCT05228314	COMPLETED	COVID-19	Clover Biopharmaceuticals AUS Pty	2022-05-30	PHASE1
NCT04753892	COMPLETED	Healthy	Imperial College London	2021-09-10
NCT04555044	Completed	Essential Fatty Acid Deficiency (EFAD)	Baxter Healthcare Corporation	2021-01-22	Phase 4
NCT03563222	Terminated	Malnutrition Child	Fresenius Kabi	2019-12-18	Phase 4
NCT02476994	Terminated	Essential Fatty Acid Deficiency (EFAD)	Baxter Healthcare Corporation	2015-05	Phase 4

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Handling Instructions

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