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Stigmasterol

Cat.No.S2361

Stigmasterol is an unsaturated plant sterol that exhibits anti-cancer, anti-pyretic, anti-inflammatory and immune-modulating effects.
Stigmasterol Chemical Structure

Chemical Structure

Molecular Weight: 412.69

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Quality Control

Batch: Purity: 99.07%
99.07

Solubility

In vitro
Batch:

DMSO : 0.1 mg/mL (0.24 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

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In vivo
Batch:

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 412.69 Formula

C29H48O

 Storage (From the date of receipt)
CAS No. 83-48-7 Download SDF Storage of Stock Solutions

Mechanism of Action

In vitro
Stigmasterol is an unsaturated plant sterol occurring in the plant fats or oils of soybean, calabar bean, and rape seed, and in a number of medicinal herbs, including the Chinese herbs Ophiopogon japonicus (Mai men dong) and American Ginseng. This compound is used as a precursor in the manufacture of synthetic progesterone, a valuable human hormone that plays an important physiological role in the regulatory and tissue rebuilding mechanisms related to estrogen effects, as well as acting as an intermediate in the biosynthesis of androgens, estrogens, and corticoids. It is also used as the precursor of vitamin D3. Research has indicated that this chemical may be useful in prevention of certain cancers, including ovarian, prostate, breast, and colon cancers.
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04555044 Completed
Essential Fatty Acid Deficiency (EFAD)
Baxter Healthcare Corporation
 January 22 2021 Phase 4
NCT03563222 Terminated
Malnutrition Child
Fresenius Kabi
 December 18 2019 Phase 4

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