Yohimbine HCl

For research use only.

Catalog No.S2373 Synonyms: Antagonil

3 publications

Yohimbine HCl Chemical Structure

CAS No. 65-19-0

Yohimbine (Antagonil) has been used as a mydriatic and in the treatment of impotence. It is also alleged to be an aphrodisiac.

Selleck's Yohimbine HCl has been cited by 3 publications

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Biological Activity

Description Yohimbine (Antagonil) has been used as a mydriatic and in the treatment of impotence. It is also alleged to be an aphrodisiac.
Targets
alpha 2-adrenergic receptor [2]
In vitro

Yohimbine(Antagonil) has been used as a mydriatic and in the treatment of impotence. It is also alleged to be an aphrodisiac. [1] Yohimbine is a pre-synaptic alpha 2-adrenergic blocking agent. Yohimbine may exert its beneficial effect on erectile ability through blockade of central alpha 2-adrenergic receptors producing an increase in sympathetic drive secondary to an increase in norepinephrine release and in firing rate of cells in the brain noradrenergic nuclei. [2]

In vivo LD50: Mice 55mg/kg (i.p.) [3]

Protocol

Solubility (25°C)

In vitro DMSO 12 mg/mL warmed (30.69 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 390.9
Formula

C21H26N2O3.HCl

CAS No. 65-19-0
Storage powder
in solvent
Synonyms Antagonil
Smiles COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O.Cl

In vivo Formulation Calculator (Clear solution)

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04346394 Not yet recruiting Drug: Yohimbine HCl Parkinson Disease Nathaniel M. Robbins|Dartmouth-Hitchcock Medical Center July 2021 Early Phase 1
NCT04051619 Recruiting Drug: intranasal oxytocin 40 IU twice a day for 7 days Opioid Use Disorder Brown University January 6 2020 Phase 1
NCT00605904 Completed Drug: Acamprosate|Drug: Yohimbine|Drug: mCPP|Drug: Saline Alcoholism National Institute on Alcohol Abuse and Alcoholism (NIAAA)|National Institutes of Health Clinical Center (CC) January 2008 Phase 2
NCT00000196 Withdrawn Drug: Naltrexone Opioid-Related Disorders Yale University|National Institute on Drug Abuse (NIDA) January 1993 Phase 2

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID