Yohimbine HCl

Catalog No.S2373 Synonyms: Antagonil

For research use only.

Yohimbine (Antagonil) has been used as a mydriatic and in the treatment of impotence. It is also alleged to be an aphrodisiac.

Yohimbine HCl Chemical Structure

CAS No. 65-19-0

Selleck's Yohimbine HCl has been cited by 4 Publications

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Biological Activity

Description Yohimbine (Antagonil) has been used as a mydriatic and in the treatment of impotence. It is also alleged to be an aphrodisiac.
Targets
alpha 2-adrenergic receptor [2]
In vitro

Yohimbine(Antagonil) has been used as a mydriatic and in the treatment of impotence. It is also alleged to be an aphrodisiac. [1] Yohimbine is a pre-synaptic alpha 2-adrenergic blocking agent. Yohimbine may exert its beneficial effect on erectile ability through blockade of central alpha 2-adrenergic receptors producing an increase in sympathetic drive secondary to an increase in norepinephrine release and in firing rate of cells in the brain noradrenergic nuclei. [2]

In vivo LD50: Mice 55mg/kg (i.p.) [3]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 390.9
Formula

C21H26N2O3.HCl

CAS No. 65-19-0
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O.Cl

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04346394 Recruiting Drug: Yohimbine HCl Parkinson Disease Nathaniel M. Robbins|Dartmouth-Hitchcock Medical Center October 11 2021 Early Phase 1
NCT04051619 Recruiting Drug: intranasal oxytocin 40 IU twice a day for 7 days Opioid Use Disorder Brown University January 6 2020 Phase 1
NCT00605904 Completed Drug: Acamprosate|Drug: Yohimbine|Drug: mCPP|Drug: Saline Alcoholism National Institute on Alcohol Abuse and Alcoholism (NIAAA)|National Institutes of Health Clinical Center (CC) January 2008 Phase 2
NCT00000196 Withdrawn Drug: Naltrexone Opioid-Related Disorders Yale University|National Institute on Drug Abuse (NIDA) January 1993 Phase 2

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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