Loureirin B

Catalog No.S3242 Synonyms: LB, LrB

For research use only.

Loureirin B (LB, LrB), a flavonoid extracted from Dracaena cochinchinensis, is an inhibitor of PAI-1 with IC50 of 26.10 μM. Loureirin B downregulates p-ERK and p-JNK in TGF-β1-stimulated fibroblasts. Loureirin B promotes insulin secretion mainly through increasing Pdx-1, MafA, intracellular ATP level, inhibiting the KATP current, influx of Ca2+ to the intracellular.

Loureirin B Chemical Structure

CAS No. 119425-90-0

Purity & Quality Control

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Biological Activity

Description Loureirin B (LB, LrB), a flavonoid extracted from Dracaena cochinchinensis, is an inhibitor of PAI-1 with IC50 of 26.10 μM. Loureirin B downregulates p-ERK and p-JNK in TGF-β1-stimulated fibroblasts. Loureirin B promotes insulin secretion mainly through increasing Pdx-1, MafA, intracellular ATP level, inhibiting the KATP current, influx of Ca2+ to the intracellular.
Targets
p-ERK [2] p-JNK [2] Calcium Channel [3] Potassium Channel [3] PAI-1 [1]
(Cell-free assay)
26.10 μM

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 316.35
Formula

C18H20O5

CAS No. 119425-90-0
Storage 3 years -20°C powder
2 years -80°C in solvent

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05053165 Recruiting Drug: LB-P6|Drug: LB-P8|Drug: Placebo Rheumatoid Arthritis|Non-Alcoholic Steatohepatitis LISCure Biosciences|Novotech (Australia) Pty Limited November 12 2021 Phase 1
NCT04390217 Not yet recruiting Drug: LB1148|Drug: Placebo COVID-19|Coronavirus Disease 2019|Covid19|COVID-19 Pneumonia Leading BioSciences Inc October 31 2021 Phase 2
NCT04712864 Recruiting Biological: LB1901 T-Cell Lymphoma|Peripheral T-Cell Lymphoma Refractory|Cutaneous T-Cell Lymphoma Refractory|Cutaneous T-Cell Lymphoma Recurrent|Peripheral T-Cell Lymphoma Recurrent Legend Biotech USA Inc September 13 2021 Phase 1
NCT05026164 Not yet recruiting Dietary Supplement: CHI-202|Dietary Supplement: CHI-101 Delayed Onset Muscle Soreness (DOMS) Canopy Growth Corporation September 6 2021 Phase 2

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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