Home Metabolism PAI-1 inhibitor - ERK inhibitor - JNK inhibitor - Potassium Channel inhibitor - Calcium Channel inhibitor Loureirin B For research use only.

Loureirin B

Synonyms: LB, LrB

Loureirin B (LB, LrB), a flavonoid extracted from Dracaena cochinchinensis, is an inhibitor of PAI-1 with IC50 of 26.10 μM. Loureirin B downregulates p-ERK and p-JNK in TGF-β1-stimulated fibroblasts. Loureirin B promotes insulin secretion mainly through increasing Pdx-1, MafA, intracellular ATP level, inhibiting the KATP current, influx of Ca2+ to the intracellular.

Loureirin B Chemical Structure

Loureirin B Chemical Structure

CAS: 119425-90-0

Purity & Quality Control

Batch: S324201 DMSO] 100 mg/mL] false] ] ] false] ] ] false Purity: 99.54%
99.54

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Biological Activity

Description Loureirin B (LB, LrB), a flavonoid extracted from Dracaena cochinchinensis, is an inhibitor of PAI-1 with IC50 of 26.10 μM. Loureirin B downregulates p-ERK and p-JNK in TGF-β1-stimulated fibroblasts. Loureirin B promotes insulin secretion mainly through increasing Pdx-1, MafA, intracellular ATP level, inhibiting the KATP current, influx of Ca2+ to the intracellular.
Targets
p-ERK [2] p-JNK [2] Calcium Channel [3] Potassium Channel [3] PAI-1 [1]
(Cell-free assay)
26.10 μM
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Chemical Information & Solubility

Molecular Weight 316.35 Formula

C18H20O5
CAS No. 119425-90-0 SDF --
Smiles COC1=CC(=C(CCC(=O)C2=CC=C(O)C=C2)C(=C1)OC)OC
Storage (From the date of receipt) 3 years -20°C powder

In vitro
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DMSO : 100 mg/mL ( (316.1 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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