Loureirin B

For research use only.

Catalog No.S3242 Synonyms: LB, LrB

Loureirin B Chemical Structure

CAS No. 119425-90-0

Loureirin B (LB, LrB), a flavonoid extracted from Dracaena cochinchinensis, is an inhibitor of PAI-1 with IC50 of 26.10 μM. Loureirin B downregulates p-ERK and p-JNK in TGF-β1-stimulated fibroblasts. Loureirin B promotes insulin secretion mainly through increasing Pdx-1, MafA, intracellular ATP level, inhibiting the KATP current, influx of Ca2+ to the intracellular.

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Biological Activity

Description Loureirin B (LB, LrB), a flavonoid extracted from Dracaena cochinchinensis, is an inhibitor of PAI-1 with IC50 of 26.10 μM. Loureirin B downregulates p-ERK and p-JNK in TGF-β1-stimulated fibroblasts. Loureirin B promotes insulin secretion mainly through increasing Pdx-1, MafA, intracellular ATP level, inhibiting the KATP current, influx of Ca2+ to the intracellular.
Targets
p-ERK [2]
()
p-JNK [2]
()
Calcium Channel [3]
()
Potassium Channel [3]
()
PAI-1 [1]
(Cell-free assay)
26.10 μM

Protocol

Solubility (25°C)

In vitro DMSO 100 mg/mL (316.1 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 316.35
Formula

C18H20O5

CAS No. 119425-90-0
Storage powder
in solvent
Synonyms LB, LrB

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04390217 Not yet recruiting Drug: LB1148|Drug: Placebo COVID-19|Coronavirus Disease 2019|Covid19|COVID-19 Pneumonia Leading BioSciences Inc October 31 2021 Phase 2
NCT04712864 Not yet recruiting Biological: LB1901 T-Cell Lymphoma|Peripheral T-Cell Lymphoma Refractory|Cutaneous T-Cell Lymphoma Refractory|Cutaneous T-Cell Lymphoma Recurrent|Peripheral T-Cell Lymphoma Recurrent Legend Biotech USA Inc September 2021 Phase 1
NCT05026164 Not yet recruiting Dietary Supplement: CHI-202|Dietary Supplement: CHI-101 Delayed Onset Muscle Soreness (DOMS) Canopy Growth Corporation September 6 2021 Phase 2
NCT04928287 Recruiting Biological: HB-adMSCs|Other: Placebo Parkinson Disease Hope Biosciences Stem Cell Research Foundation|Hope Biosciences June 28 2021 Phase 2
NCT04581785 Recruiting Biological: hLB-001 Methylmalonic Acidemia LogicBio Therapeutics Inc. May 29 2021 Phase 1|Phase 2

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID