For research use only.
Catalog No.S4708 Synonyms: Palmidrol|N-palmitoylethanolamine
CAS No. 544-31-0
Palmitoylethanolamide (PEA, Palmidrol, N-palmitoylethanolamine) is an endogenous fatty acid amide and selectively activates PPAR-α in vitro with an EC50 value of 3.1±0.4 μM.
Selleck's Palmitoylethanolamide has been cited by 2 publications
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|Description||Palmitoylethanolamide (PEA, Palmidrol, N-palmitoylethanolamine) is an endogenous fatty acid amide and selectively activates PPAR-α in vitro with an EC50 value of 3.1±0.4 μM.|
PEA protects cultured mouse cerebellar granule cells from glutamate toxicity and enhances microglial cell motility. In the mitochondrial fraction from cells stimulated with PEA, steroidogenic acute regulatory protein (StAR) and cytochrome P450 enzyme(P450scc) expression increases, both comprising proteins considered to be involved in crucial steps of neurosteroid formation. Moreover, PEA shows a protective effect, reducing malondialdehyde formation in cells treated with L-buthionine-(S,R)-sulfoximine, a glutathione depletor and the effect of PEA is partially inhibited by finasteride, a 5a-reductase inhibitor.
|In vivo||PEA attenuates inflammation in wild-type mice but has no effect in mice deficient in PPAR-α. PEA has been shown to inhibit peripheral inflammation and mast-cell degranulation as well as to exert neuroprotective and antinociceptive effects in rats and mice. These actions are accompanied by changes in nitric oxide production, neutrophil influx, and expression of proinflammatory proteins such as inducible nitric oxide synthase and cyclooxygenase-2. In addition to its known anti-inflammatory activity, PEA regulates many pathophysiological processes, including pain perception, convulsions, and neurotoxicity. In the central nervous system (CNS), where PEA is present at detectable levels, its concentrations significantly increase under pathological conditions, such as excitotoxicity, brain ischaemia and neuroinflammation.|
|In vitro||DMSO||59 mg/mL (197.0 mM)|
|Ethanol||59 mg/mL (197.0 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT03564379||Completed||Drug: JNJ-42165279|Drug: Placebo||Healthy||Janssen Research & Development LLC||June 12 2018||Phase 1|
|NCT01092845||Completed||Drug: PF-04457845 / matched placebo||Healthy|Sleep||Pfizer||April 2010||Phase 1|
|NCT01370720||Unknown status||Dietary Supplement: Recoclix|Other: Placebo||Irritable Bowel Syndrome||MARIA CRISTINA COMELLI|CM&D Pharma Limited||February 2010||Phase 2|
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