Home MAPK ERK inhibitor - NF-κB inhibitor Hypaphorine

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Hypaphorine ERK inhibitor

Cat.No.S0911

Hypaphorine which is abundantly found in vaccaria semen, counteracts inflammation via inhibition of ERK or/and NFκB signaling pathways.
Hypaphorine ERK inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 246.3

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Quality Control

Batch: S091101 Water]16 mg/mL]false]DMSO]Insoluble]false]Ethanol]Insoluble]false Purity: 99.99%
99.99

Chemical Information, Storage & Stability

Molecular Weight 246.3 Formula

C14H18N2O2

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 487-58-1 -- Storage of Stock Solutions

Synonyms N/A Smiles C[N+](C)(C)C(CC1=CNC2=CC=CC=C21)C(=O)[O-]

Solubility

In vitro
Batch:

Water : 16 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
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Mechanism of Action

In vitro

Hypaphorine down-regulates LPS-stimulated expressions of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), retards LPS-induced phosphorylation of ERK, nuclear factor kappa beta (NFκB), NFκB inhibitor IκBα, and IKKβ, also eliminates the nuclear translocation of NFκB in LPS-treated RAW 264.7 cells.[1]
In vivo

Hypaphorine impairs RANKL-induced osteoclastogenesis through reduction of extracellular signal-regulated kinases (ERK), p38, c-Jun N-terminal kinase (JNK) and NF-κB p65 phosphorylation, which is considered as potential therapeutic agent for treating osteoclast-based bone loss.[2]
References

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