Home MAPK ERK inhibitor Hypaphorine

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Hypaphorine ERK inhibitor

Cat.No.S0911

Hypaphorine which is abundantly found in vaccaria semen, counteracts inflammation via inhibition of ERK or/and NFκB signaling pathways.
Hypaphorine ERK inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 246.3

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Quality Control

Batch: S091101 Water]16 mg/mL]false]DMSO]Insoluble]false]Ethanol]Insoluble]false Purity: 99.99%
99.99

Solubility

In vitro
Batch:

Water : 16 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : Insoluble

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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Chemical Information, Storage & Stability

Molecular Weight 246.3 Formula

C14H18N2O2

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 487-58-1 -- Storage of Stock Solutions

Synonyms N/A Smiles C[N+](C)(C)C(CC1=CNC2=CC=CC=C21)C(=O)[O-]

Mechanism of Action

In vitro

Hypaphorine down-regulates LPS-stimulated expressions of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), retards LPS-induced phosphorylation of ERK, nuclear factor kappa beta (NFκB), NFκB inhibitor IκBα, and IKKβ, also eliminates the nuclear translocation of NFκB in LPS-treated RAW 264.7 cells.
In vivo

Hypaphorine impairs RANKL-induced osteoclastogenesis through reduction of extracellular signal-regulated kinases (ERK), p38, c-Jun N-terminal kinase (JNK) and NF-κB p65 phosphorylation, which is considered as potential therapeutic agent for treating osteoclast-based bone loss.
References

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