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Aloin

For research use only.

Catalog No.S2375 Synonyms: Barbaloin, Barbalin

5 publications

Aloin Chemical Structure

CAS No. 1415-73-2

Aloin (Barbaloin, Barbalin), a natural anthracycline from Aloe vera, is a tyrosinase inhibitor.

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10mM (1mL in DMSO) USD 70 In stock
USD 79 In stock
USD 109 In stock
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Selleck's Aloin has been cited by 5 publications

Purity & Quality Control

Choose Selective Tyrosinase Inhibitors

Biological Activity

Description Aloin (Barbaloin, Barbalin), a natural anthracycline from Aloe vera, is a tyrosinase inhibitor.
Targets
tyrosinase [1]
In vitro

Aloin, a natural anthracycline from Aloe vera, is a tyrosinase inhibitor with inhibitory rates of 2mM. [1] Aloin shows a pronounced antiproliferative effect at physiological concentration (IC50 = 97 μM), causes cell cycle arrest in the S phase and markedly increases HeLaS3 cell apoptosis (to 24%). [2] Aloin causes a reduction in the proportion of cells undergoing mitosis by induction of apoptosis, inhibition of topo II alpha protein expression and downregulation of cyclin B1 protein expression in MCF-7 cell line. [3]

Protocol

Solubility (25°C)

In vitro DMSO 83 mg/mL (198.37 mM)
Water 83 mg/mL (198.37 mM)
Ethanol 2 mg/mL (4.78 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 418.39
Formula

C21H22O9

CAS No. 1415-73-2
Storage powder
in solvent
Synonyms Barbaloin, Barbalin
Smiles C1=CC2=C(C(=C1)O)C(=O)C3=C(C2C4C(C(C(C(O4)CO)O)O)O)C=C(C=C3O)CO

In vivo Formulation Calculator (Clear solution)

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Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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  • Computed Result

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Molecular Weight Calculator

Molecular Weight Calculator

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Total Molecular Weight: g/mol

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Instructions to calculate molar mass (molecular weight) of a chemical compound:

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID