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Ethyl ferulate

Name: Ethyl ferulate
Brand: Selleck Chemicals
SKU: S3855
Rating: 5 (1 reviews)

Synonyms: Ferulic acid ethyl ester, Ethyl 4'-hydroxy-3'-methoxycinnamate, Ethyl 3-(4-hydroxy-3-methoxyphenyl)acrylate

Catalog No.S3855 Purity: 99.92%

Ethyl ferulate (Ferulic acid ethyl ester) is the alkyl ester derivative of ferulic acid which is a naturally occurring plant product with anti-oxidative, anti-inflammatory, neuroprotective, and antiproliferative activities.

Ethyl ferulate Chemical Structure

CAS: 4046-02-0

Purity & Quality Control

Batch: S385501 DMSO] 44 mg/mL] false] ] ] false] ] ] false Purity: 99.92%

99.92

Ethyl ferulate Related Products

Biological Activity

Description	Ethyl ferulate (Ferulic acid ethyl ester) is the alkyl ester derivative of ferulic acid which is a naturally occurring plant product with anti-oxidative, anti-inflammatory, neuroprotective, and antiproliferative activities.

In vitro
In vitro	Ethyl ferulate is an inducer of HO-1 expression, at both mRNA and protein levels, and HO activity in cultured astrocytes and hippocampal neurons^[1].
Cell Research	Cell lines	Rat type 1 astrocytes (DI TNC1) and rat hippocampal neurons (H 19-7)
	Concentrations	0-25 μM
	Incubation Time	6 or 24 h
	Method	Cells are grown in 75-cm² flasks and maintained at 37℃ in a humidified atmosphere of air and 5% CO2. Confluent cells are exposed to various concentrations of EFE and RSV. After each treatment (6 or 24 h), cells are harvested for the determination of HO activity, HO-1 and HO-2 mRNA levels, and protein expression. Neurons growing in 24 wells are also exposed to different concentrations of EFE, and cell viability is determined at 24 h. Other neurons are pretreated for 12 h with 5 µM EFE or 5 µM EFE plus 10 µM ZnPP IX and then exposed for 2 h to 50 mU/mL GOX, before cell viability is determined.

References

[1] Scapagnini G, et al. Antioxid Redox Signal. 2004, 6(5):811-8.

Chemical Information & Solubility

Molecular Weight	222.24	Formula	C₁₂H₁₄O₄
CAS No.	4046-02-0	SDF	--
Smiles	CCOC(=O)C=CC1=CC(=C(C=C1)O)OC
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 44 mg/mL ( (197.98 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

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In vivo
Batch:

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

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% DMSO + % + % Tween 80 + % ddH₂O

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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