Ethyl ferulate

Catalog No.S3855 Synonyms: Ferulic acid ethyl ester, Ethyl 4'-hydroxy-3'-methoxycinnamate, Ethyl 3-(4-hydroxy-3-methoxyphenyl)acrylate

For research use only.

Ethyl ferulate (Ferulic acid ethyl ester) is the alkyl ester derivative of ferulic acid which is a naturally occurring plant product with anti-oxidative, anti-inflammatory, neuroprotective, and antiproliferative activities.

Ethyl ferulate Chemical Structure

CAS No. 4046-02-0

Purity & Quality Control

Related Other Products

Biological Activity

Description Ethyl ferulate (Ferulic acid ethyl ester) is the alkyl ester derivative of ferulic acid which is a naturally occurring plant product with anti-oxidative, anti-inflammatory, neuroprotective, and antiproliferative activities.
In vitro

Ethyl ferulate is an inducer of HO-1 expression, at both mRNA and protein levels, and HO activity in cultured astrocytes and hippocampal neurons[1].

Protocol (from reference)

Cell Research:[1]
  • Cell lines: Rat type 1 astrocytes (DI TNC1) and rat hippocampal neurons (H 19-7)
  • Concentrations: 0-25 μM
  • Incubation Time: 6 or 24 h
  • Method: Cells are grown in 75-cm2 flasks and maintained at 37℃ in a humidified atmosphere of air and 5% CO2. Confluent cells are exposed to various concentrations of EFE and RSV. After each treatment (6 or 24 h), cells are harvested for the determination of HO activity, HO-1 and HO-2 mRNA levels, and protein expression. Neurons growing in 24 wells are also exposed to different concentrations of EFE, and cell viability is determined at 24 h. Other neurons are pretreated for 12 h with 5 µM EFE or 5 µM EFE plus 10 µM ZnPP IX and then exposed for 2 h to 50 mU/mL GOX, before cell viability is determined.
  • (Only for Reference)

Solubility (25°C)

In vitro

DMSO 44 mg/mL
(197.98 mM)


* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 222.24
Formula

C12H14O4

CAS No. 4046-02-0
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCOC(=O)C=CC1=CC(=C(C=C1)O)OC

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Ethyl ferulate | Ethyl ferulate supplier | purchase Ethyl ferulate | Ethyl ferulate cost | Ethyl ferulate manufacturer | order Ethyl ferulate | Ethyl ferulate distributor