Home Transmembrane Transporters CFTR inhibitor - Aquaporin inhibitor Steviol (Hydroxydehydrostevic acid) For research use only.

Steviol (Hydroxydehydrostevic acid)

Synonyms: Hydroxy Dehydrostevic Acid, NSC 226902

Steviol (Hydroxydehydrostevic acid, Hydroxy Dehydrostevic Acid, NSC 226902), a major metabolite of the sweetening compound stevioside, inhibits CFTR activity, reduces AQP2 expression and promotes AQP2 degradation.

Steviol (Hydroxydehydrostevic acid) Chemical Structure

Steviol (Hydroxydehydrostevic acid) Chemical Structure

CAS: 471-80-7

Purity & Quality Control

Batch: S327201 DMSO] 100 mg/mL] false] ] ] false] ] ] false Purity: 99.22%
99.22

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Signaling Pathway

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Biological Activity

Description Steviol (Hydroxydehydrostevic acid, Hydroxy Dehydrostevic Acid, NSC 226902), a major metabolite of the sweetening compound stevioside, inhibits CFTR activity, reduces AQP2 expression and promotes AQP2 degradation.
Targets
CFTR [1] AQP2 [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05264636 Completed
Healthy|Human Gut Microflora
Cargill|INQUIS Clinical Research
 February 15 2022 Not Applicable
NCT03510624 Completed
Type 2 Diabetes Mellitus
Universitaire Ziekenhuizen KU Leuven
 November 9 2018 Phase 1

Chemical Information & Solubility

Molecular Weight 318.45 Formula

C20H30O3
CAS No. 471-80-7 SDF --
Smiles CC12CCCC(C)(C1CCC34CC(=C)C(O)(CCC23)C4)C(O)=O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (314.02 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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