Home Transmembrane Transporters CFTR inhibitor - Aquaporin inhibitor Steviol (Hydroxydehydrostevic acid)

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Steviol (Hydroxydehydrostevic acid) CFTR inhibitor

Cat.No.S3272

Steviol (Hydroxydehydrostevic acid, Hydroxy Dehydrostevic Acid, NSC 226902), a major metabolite of the sweetening compound stevioside, inhibits CFTR activity, reduces AQP2 expression and promotes AQP2 degradation.
Steviol (Hydroxydehydrostevic acid) CFTR inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 318.45

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: S327201 DMSO]100 mg/mL]false]]]false]]]false Purity: 99.22%
99.22

Chemical Information, Storage & Stability

Molecular Weight 318.45 Formula

C20H30O3

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 471-80-7 -- Storage of Stock Solutions

Synonyms Hydroxy Dehydrostevic Acid, NSC 226902 Smiles CC12CCCC(C)(C1CCC34CC(=C)C(O)(CCC23)C4)C(O)=O

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (314.02 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC50/Ki
CFTR [1]
AQP2 [1]
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05264636 Completed
Healthy|Human Gut Microflora
Cargill|INQUIS Clinical Research
 February 15 2022 Not Applicable
NCT03510624 Completed
Type 2 Diabetes Mellitus
Universitaire Ziekenhuizen KU Leuven
 November 9 2018 Phase 1

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