Eicosapentaenoic acid ethyl ester

For research use only.

Catalog No.S6466 Synonyms: AMR101, EPA ethyl ester, Ethyl eicosapentaenoate

Eicosapentaenoic acid ethyl ester Chemical Structure

CAS No. 86227-47-6

Eicosapentaenoic acid ethyl ester (AMR101, EPA ethyl ester, Ethyl eicosapentaenoate) is an omega-3 fatty acid agent that significantly reduces the triglyceride (TG) levels and improves other lipid parameters without significantly increasing the low-density lipoprotein (LDL) cholesterol levels.

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Biological Activity

Description Eicosapentaenoic acid ethyl ester (AMR101, EPA ethyl ester, Ethyl eicosapentaenoate) is an omega-3 fatty acid agent that significantly reduces the triglyceride (TG) levels and improves other lipid parameters without significantly increasing the low-density lipoprotein (LDL) cholesterol levels.
Targets
Triglyceride [1]
()

Protocol

Solubility (25°C)

Chemical Information

Molecular Weight 330.50
Formula

C22H34O2

CAS No. 86227-47-6
Storage 2 years -20°C liquid
Synonyms AMR101, EPA ethyl ester, Ethyl eicosapentaenoate

In vivo Formulation Calculator (Clear solution)

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Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

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Molecular Weight Calculator

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04216251 Recruiting Drug: AMR101 Colorectal Adenoma|Colorectal Cancer|Endoscopic Surgery|Eicosapentaenoic Acid|Gastrointestinal Microbiome Massachusetts General Hospital|National Institutes of Health (NIH) March 19 2020 Phase 1|Phase 2
NCT03661047 Recruiting Drug: AMR101 (VASCEPA icosapent ethyl) Colon Cancer Mingyang Song|Harvard School of Public Health|Massachusetts General Hospital November 30 2019 Phase 2
NCT01047683 Completed Drug: AMR101 (ethyl icosapentate)|Drug: Placebo Hypertriglyceridemia Amarin Pharma Inc. December 2009 Phase 3
NCT01047501 Completed Drug: AMR101 (ethyl icosapentate)|Drug: Placebo Hypertriglyceridemia Amarin Pharma Inc. December 2009 Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID