Eicosapentaenoic acid ethyl ester

Catalog No.S6466 Synonyms: AMR101, EPA ethyl ester, Ethyl eicosapentaenoate

For research use only.

Eicosapentaenoic acid ethyl ester (AMR101, EPA ethyl ester, Ethyl eicosapentaenoate) is an omega-3 fatty acid agent that significantly reduces the triglyceride (TG) levels and improves other lipid parameters without significantly increasing the low-density lipoprotein (LDL) cholesterol levels.

Eicosapentaenoic acid ethyl ester Chemical Structure

CAS No. 86227-47-6

Purity & Quality Control

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Biological Activity

Description Eicosapentaenoic acid ethyl ester (AMR101, EPA ethyl ester, Ethyl eicosapentaenoate) is an omega-3 fatty acid agent that significantly reduces the triglyceride (TG) levels and improves other lipid parameters without significantly increasing the low-density lipoprotein (LDL) cholesterol levels.
Targets
Triglyceride [1]
()

Protocol (from reference)

Chemical Information

Molecular Weight 330.50
Formula

C22H34O2

CAS No. 86227-47-6
Storage 2 years -20°C liquid

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04216251 Recruiting Drug: AMR101 Colorectal Adenoma|Colorectal Cancer|Endoscopic Surgery|Eicosapentaenoic Acid|Gastrointestinal Microbiome Massachusetts General Hospital|National Institutes of Health (NIH) March 19 2020 Phase 1|Phase 2
NCT03661047 Withdrawn Drug: AMR101 (VASCEPA icosapent ethyl) Colon Cancer Massachusetts General Hospital|Harvard School of Public Health (HSPH) November 30 2019 Phase 2
NCT01047683 Completed Drug: AMR101 (ethyl icosapentate)|Drug: Placebo Hypertriglyceridemia Amarin Pharma Inc. December 2009 Phase 3
NCT01047501 Completed Drug: AMR101 (ethyl icosapentate)|Drug: Placebo Hypertriglyceridemia Amarin Pharma Inc. December 2009 Phase 3

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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