Home Transmembrane Transporters ATPase inhibitor Acevaltrate For research use only.

Acevaltrate

Acevaltrate, an active component derived from the herbal plant Valeriana jatamansi Jones, is strikingly potent to induce GBM cell apoptosis. Acevaltrate inhibits the Na+/K+-ATPase activity in the rat kidney and brain hemispheres with IC50 of 22.8 μM and 42.3 μM, respectively.

Acevaltrate Chemical Structure

Acevaltrate Chemical Structure

CAS: 25161-41-5

Purity & Quality Control

Batch: E024401 DMSO] 96 mg/mL] false] ] ] false] ] ] false Purity: 99.89%
99.89

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Biological Activity

Description Acevaltrate, an active component derived from the herbal plant Valeriana jatamansi Jones, is strikingly potent to induce GBM cell apoptosis. Acevaltrate inhibits the Na+/K+-ATPase activity in the rat kidney and brain hemispheres with IC50 of 22.8 μM and 42.3 μM, respectively.
Targets
Na+/K+-ATPase [1]
(in the rat kidney)		 Na+/K+-ATPase [1]
(in the rat brain hemispheres)
22.8 μM 42.3 μM
In vitro
In vitro

Acevaltrate disrupts the interaction of Otub1/c-Maf thus inhibiting Otub1 activity and leading to c-Maf polyubiquitination and subsequent degradation in proteasomes. Consistently, acevaltrate inhibits c-Maf transcriptional activity and downregulates the expression of its target genes key for myeloma growth and survival.[1]
Cell Research Cell lines MM cell lines (RPMI-8226, LP1, KMS11, OPM2, U266)
Concentrations 1, 2, 4 µM
Incubation Time 24 h
Method

RPMI-8226 cells are transfected with plasmids as indicated for 48 h. Cells are then re-plated and treated with 0.1% DMSO or acevaltrate for 24 h before being harvested for luciferase activity measurements. MM cells are treated with acevaltrate for 24 h, followed by WB or RT-PCR assays to evaluate the expression of specifc genes.
In Vivo
In vivo

Acevaltrate displays potent anti-myeloma activity by triggering myeloma cell apoptosis in vitro and impairing myeloma xenograft growth in vivo but presents no marked toxicity.[1]
Animal Research Animal Models Nude mice of myeloma xenograft model
Dosages 50 mg/kg
Administration p.o.

Chemical Information & Solubility

Molecular Weight 480.51 Formula

C24H32O10
CAS No. 25161-41-5 SDF --
Storage (From the date of receipt) 3 years -20°C powder

In vitro
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DMSO : 96 mg/mL ( (199.78 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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