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Evodiamine

Catalog No.S2382 Synonyms: Isoevodiamine

For research use only.

Evodiamine (Isoevodiamine), an alkaloid extract from the fruit of Evodiae Fructus exhibits antitumor activities against the human tumor cells. It is shown to inhibit NF-kB activation through suppression of IkB kinase activity.

Evodiamine Chemical Structure

CAS No. 518-17-2

Selleck's Evodiamine has been cited by 8 Publications

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Biological Activity

Description Evodiamine (Isoevodiamine), an alkaloid extract from the fruit of Evodiae Fructus exhibits antitumor activities against the human tumor cells. It is shown to inhibit NF-kB activation through suppression of IkB kinase activity.
Targets
NF-κB [2]
()
In vitro

Evodiamine (Isoevodiamine), an alkaloid extract from Evodiae Fructus exhibits antitumor activities against the human tumor cells. Evodiamine induces the substantial amount of apoptosis both in Bcl-2- and Akt-overexpressing U937 cells but not in human peripheral blood mononuclear cells via caspase-independent apoptotic pathways. [1] Evodiamine Evodiamine also inhibits tumor necrosis factor (TNF)-induced NF-kappaB and Akt activation but it has no effect on JNK or p38 MAPK activation. [2] In addition, Evodiamine is an human topoisomerase I inhibitor. [3]
In vivo LD50: Mice 77mg/kg (i.v.) [4]

Protocol (from reference)

Solubility (25°C)

In vitro

 DMSO Insoluble
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 303.36
Formula

C19H17N3O
CAS No. 518-17-2
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CN1C2C3=C(CCN2C(=O)C4=CC=CC=C41)C5=CC=CC=C5N3

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