3',3'-cGAMP

For research use only.

Catalog No.S7905 Synonyms: 3',3'-cyclic GMP-AMP, Cyclic GMP-AMP, cGAMP

3',3'-cGAMP Chemical Structure

CAS No. 849214-04-6(freeacid)

3',3'-cGAMP (3',3'-cyclic GMP-AMP, Cyclic GMP-AMP, cGAMP) activates the endoplasmic reticulum (ER)-resident receptor stimulator of interferon genes (STING), thereby inducing an antiviral state and the secretion of type I IFNs.

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Biological Activity

Description 3',3'-cGAMP (3',3'-cyclic GMP-AMP, Cyclic GMP-AMP, cGAMP) activates the endoplasmic reticulum (ER)-resident receptor stimulator of interferon genes (STING), thereby inducing an antiviral state and the secretion of type I IFNs.
Targets
STING [1]
()
In vivo

Sublingual immunization of mice with Bacillus anthracis protective antigen (PA) and the STING ligand 3′3′-cGAMP promotes PA-specific serum IgG Ab responses of the same magnitude as those induced after immunization with PA and the experimental adjuvants cholera toxin (CT). 3′3′-cGAMP also promotes serum anti-PA IgA and IgA-producing cells in the bone marrow. Furthermore, the saliva of mice immunized with 3′3′-cGAMP exhibits similar levels of PA-specific IgA Abs as groups immunized with CT as adjuvant. The adjuvant activity of 3′3′-cGAMP is associated with mixed Th1, Th2, and Th17 responses. 3′3′-cGAMP also induces rapid IFN-β and IL-10 responses in sublingual tissues and cervical lymph nodes, and TGF-β responses in the cervical lymph nodes, which can contribute to promoting IgA responses after sublingual immunization.[1]

Protocol

Animal Research:

[1]

- Collapse
  • Animal Models: 9–12 week old female C57BL/6J mice
  • Dosages: 10 μg
  • Administration: Oral gavage
    (Only for Reference)

Solubility (25°C)

In vitro Water 100 mg/mL (148.72 mM)
DMSO 20 mg/mL (29.74 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 672.4
Formula

C20H24N10O13 P2·xNa+

CAS No. 849214-04-6(freeacid)
Storage powder
in solvent
Synonyms 3',3'-cyclic GMP-AMP, Cyclic GMP-AMP, cGAMP
Smiles C1C2C(C(C(O2)N3C=NC4=C3N=C(NC4=O)N)O)OP(=O)(OCC5C(C(C(O5)N6C=NC7=C(N=CN=C76)N)O)OP(=O)(O1)O)O

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02986867 Completed Radiation: SAbR Treatment of Lesions Urothelial Carcinoma|Melanoma|Cervical Carcinoma in Situ University of Texas Southwestern Medical Center June 13 2017 Not Applicable

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID