3',3'-cGAMP

Catalog No.S7905 Synonyms: 3',3'-cyclic GMP-AMP, Cyclic GMP-AMP, cGAMP

For research use only.

3',3'-cGAMP (3',3'-cyclic GMP-AMP, Cyclic GMP-AMP, cGAMP) activates the endoplasmic reticulum (ER)-resident receptor stimulator of interferon genes (STING), thereby inducing an antiviral state and the secretion of type I IFNs.

3',3'-cGAMP Chemical Structure

CAS No. 849214-04-6(freeacid)

Purity & Quality Control

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Biological Activity

Description 3',3'-cGAMP (3',3'-cyclic GMP-AMP, Cyclic GMP-AMP, cGAMP) activates the endoplasmic reticulum (ER)-resident receptor stimulator of interferon genes (STING), thereby inducing an antiviral state and the secretion of type I IFNs.
Targets
STING [1]
In vivo

Sublingual immunization of mice with Bacillus anthracis protective antigen (PA) and the STING ligand 3′3′-cGAMP promotes PA-specific serum IgG Ab responses of the same magnitude as those induced after immunization with PA and the experimental adjuvants cholera toxin (CT). 3′3′-cGAMP also promotes serum anti-PA IgA and IgA-producing cells in the bone marrow. Furthermore, the saliva of mice immunized with 3′3′-cGAMP exhibits similar levels of PA-specific IgA Abs as groups immunized with CT as adjuvant. The adjuvant activity of 3′3′-cGAMP is associated with mixed Th1, Th2, and Th17 responses. 3′3′-cGAMP also induces rapid IFN-β and IL-10 responses in sublingual tissues and cervical lymph nodes, and TGF-β responses in the cervical lymph nodes, which can contribute to promoting IgA responses after sublingual immunization.[1]

Protocol (from reference)

Animal Research:

[1]

  • Animal Models: 9–12 week old female C57BL/6J mice
  • Dosages: 10 μg
  • Administration: Oral gavage

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 672.4
Formula

C20H24N10O13 P2·xNa+

CAS No. 849214-04-6(freeacid)
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1C2C(C(C(O2)N3C=NC4=C3N=C(NC4=O)N)O)OP(=O)(OCC5C(C(C(O5)N6C=NC7=C(N=CN=C76)N)O)OP(=O)(O1)O)O

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02986867 Completed Radiation: SAbR Treatment of Lesions Urothelial Carcinoma|Melanoma|Cervical Carcinoma in Situ University of Texas Southwestern Medical Center June 13 2017 Not Applicable

(data from https://clinicaltrials.gov, updated on 2022-08-01)

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