Guaiazulene

Catalog No.S3995 Synonyms: Azulon, Vetivazulen

For research use only.

Guaiazulene (Azulon, Vetivazulen) is a bicyclic sesquiterpene that is a constituent of some essential oils, mainly oil of guaiac and chamomile oil, which also serve as its commercial sources.

Guaiazulene Chemical Structure

CAS No. 489-84-9

Purity & Quality Control

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Biological Activity

Description Guaiazulene (Azulon, Vetivazulen) is a bicyclic sesquiterpene that is a constituent of some essential oils, mainly oil of guaiac and chamomile oil, which also serve as its commercial sources.
In vitro

Guaiazulene has in vitro cytotoxic activity against neuron and N2a-NB cells[1].

Protocol (from reference)

Cell Research:

[1]

  • Cell lines: N2a-NB cells
  • Concentrations: 10, 25, 50, 75, 100, 150, 200 and 400 mg/L
  • Incubation Time: 24 h
  • Method:

    The cells were seeded in 96-well plastic plates at a density of 1×104 cells/well and incubated in a humidified atmosphere of 5% CO2 at 37°C for 24 h. Cell viability assay was performed using the MTT cell proliferation kit. Pure water was added in the control group. At the end of the experiment, the neurons, and N2a-NB cells were incubated with 20 µL of MTT for 30 min at 37°C. After washing the blue formazan was extracted from cells with isopropanol/formic acid (955)and was photometrically determined at 570 nm.

  • (Only for Reference)

Solubility (25°C)

In vitro

DMSO 39 mg/mL
(196.67 mM)


* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 198.30
Formula

C15H18

CAS No. 489-84-9
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1=C2C=CC(=C2C=C(C=C1)C(C)C)C

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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