Vitamin E

Catalog No.S4686 Synonyms: Alpha-Tocopherol, D-alpha-Tocopherol, 5,7,8-Trimethyltocol|(+)-alpha-Tocopherol

For research use only.

Vitamin E (D-alpha-Tocopherol) is a fat-soluble vitamin with potent antioxidant properties. It is a potent peroxyl radical scavenger and inhibits noncompetitively cyclooxygenase activity in many tissues, also inhibits angiogenesis and tumor dormancy through suppressing vascular endothelial growth factor (VEGF) gene transcription.

Vitamin E Chemical Structure

CAS No. 59-02-9

Selleck's Vitamin E has been cited by 5 Publications

Purity & Quality Control

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Biological Activity

Description Vitamin E (D-alpha-Tocopherol) is a fat-soluble vitamin with potent antioxidant properties. It is a potent peroxyl radical scavenger and inhibits noncompetitively cyclooxygenase activity in many tissues, also inhibits angiogenesis and tumor dormancy through suppressing vascular endothelial growth factor (VEGF) gene transcription.
Targets
COX [2] VEGFR [3]
In vitro

vitamin E is capable of inducing necrosis in TC-1 cells and has antioxidant effects against nitric oxide[1].

In vivo

Vitamin E induces TC-1 cell necrosis in vivo and reduces tumor volume in TC-1 tumor-bearing mice. Vitamin E reduces myeloid derived suppressor cells(MDSCs) in tumors of TC-1 tumor-bearing mice and enhances T cell accumulation[1].

Protocol (from reference)

Cell Research:

[1]

  • Cell lines: TC-1 cells
  • Concentrations: 0, 25, 50 μM
  • Incubation Time: 18 h
  • Method:

    For in vitro cytotoxicity experiments, 1×105 TC-1 cells per well are added to 24-well plates. Eighteen hours later, tumor cells are treated with Vitamin E (0, 25, 50 μM). After 18 hours, apoptotic (Annexin V+ and 7AAD−) and necrotic (Annexin V+ and 7AAD+) cells are measured using PE Annexin V Apoptosis Detection Kit I.

Animal Research:

[1]

  • Animal Models: C57BL/6 mice 
  • Dosages: 2 mg/kg
  • Administration: i.p.

Chemical Information

Molecular Weight 430.71
Formula

C29H50O2

Density 0.95 g/mL at 25 °C
CAS No. 59-02-9
Storage 2 years -20°C liquid
Smiles CC1=C(C2=C(CCC(O2)(C)CCCC(C)CCCC(C)CCCC(C)C)C(=C1O)C)C

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05474105 Not yet recruiting Dietary Supplement: Oral nutritional supplement Ischemic Stroke Barts & The London NHS Trust|Queen Mary University of London|Nutricia Research October 2022 Not Applicable
NCT04984798 Not yet recruiting Drug: Vitamin E Hyperinsulinism-Hyperammonemia Syndrome Children''s Hospital of Philadelphia|University of Pennsylvania|Lawson Wilkins Pediatric Endocrine Society August 2022 Phase 2
NCT05440604 Recruiting Other: Fortified milk Nutritional Status|Child Nutrition Sciences|Toddlers Nestlé June 23 2022 Not Applicable
NCT05293353 Recruiting Other: NeoKare Breast Milk Fortifier NEC|Gastroschisis|Intestinal Perforation|Atresia Intestinal|Hirschsprung Disease|Exomphalos|Volvulus|Anorectal Malformations|Meconium Ileus|Cows Milk Allergy|Preterm University Hospital Southampton NHS Foundation Trust|University of Southampton|NeoKare Nutrition Ltd May 10 2022 --
NCT05382533 Recruiting Dietary Supplement: Menu plans Decreased Cardovascular Risk|Decreased Risk of Diabetes Mellitus Type II University of Jena May 30 2022 Not Applicable

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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