Vitamin E

Catalog No.S4686 Synonyms: Alpha-Tocopherol, D-alpha-Tocopherol, 5,7,8-Trimethyltocol|(+)-alpha-Tocopherol

Vitamin E Chemical Structure

Molecular Weight(MW): 430.71

Vitamin E is a fat-soluble vitamin with potent antioxidant properties. It is a potent peroxyl radical scavenger and inhibits noncompetitively cyclooxygenase activity in many tissues, also inhibits angiogenesis and tumor dormancy through suppressing vascular endothelial growth factor (VEGF) gene transcription.

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Biological Activity

Description Vitamin E is a fat-soluble vitamin with potent antioxidant properties. It is a potent peroxyl radical scavenger and inhibits noncompetitively cyclooxygenase activity in many tissues, also inhibits angiogenesis and tumor dormancy through suppressing vascular endothelial growth factor (VEGF) gene transcription.
In vitro

vitamin E is capable of inducing necrosis in TC-1 cells and has antioxidant effects against nitric oxide[1].

In vivo Vitamin E induces TC-1 cell necrosis in vivo and reduces tumor volume in TC-1 tumor-bearing mice. Vitamin E reduces myeloid derived suppressor cells(MDSCs) in tumors of TC-1 tumor-bearing mice and enhances T cell accumulation[1].

Protocol

Cell Research:

[1]

+ Expand
  • Cell lines: TC-1 cells
  • Concentrations: 0, 25, 50 μM
  • Incubation Time: 18 h
  • Method:

    For in vitro cytotoxicity experiments, 1×105 TC-1 cells per well are added to 24-well plates. Eighteen hours later, tumor cells are treated with Vitamin E (0, 25, 50 μM). After 18 hours, apoptotic (Annexin V+ and 7AAD−) and necrotic (Annexin V+ and 7AAD+) cells are measured using PE Annexin V Apoptosis Detection Kit I.


    (Only for Reference)
Animal Research:

[1]

+ Expand
  • Animal Models: C57BL/6 mice 
  • Formulation: DMSO
  • Dosages: 2 mg/kg
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

Chemical Information

Molecular Weight 430.71
Formula

C29H50O2

CAS No. 59-02-9
Storage powder
in solvent
Synonyms Alpha-Tocopherol, D-alpha-Tocopherol, 5,7,8-Trimethyltocol|(+)-alpha-Tocopherol

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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  • Computed Result

  • C1=C0/X C1: LOG(C1):
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    C4=C3/X C4: LOG(C4):
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Molecular Weight Calculator

Molecular Weight Calculator

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Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03613389 Enrolling by invitation Oral Mucositis (Ulcerative) Due to Antineoplastic Therapy Cairo University|National Cancer Institute (NCI) January 1 2019 Not Applicable
NCT03669133 Recruiting NAFLD|NASH - Nonalcoholic Steatohepatitis|HIV Infections Indiana University School of Medicine|Indiana University December 31 2018 Phase 2
NCT03416777 Not yet recruiting Nutrition Aspect of Cancer|Diet Modification|Cancer of Colon Azienda Ospedaliero-Universitaria Careggi October 1 2018 Not Applicable
NCT03668964 Enrolling by invitation Healthy Volunteers DSM Nutritional Products Inc.|Atlantia Food Clinical Trials August 20 2018 Not Applicable
NCT03557229 Recruiting Oxidative Stress|Septic Shock American British Cowdray Medical Center July 23 2018 Phase 3
NCT03674385 Recruiting Clomiphene Citrate Resistant Polycystic Ovary Syndrome Ain Shams University|Misr University for Science and Technology July 19 2018 Phase 2

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID