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Vitamin E COX inhibitor

Name: Vitamin E
Brand: Selleck Chemicals
SKU: S4686
Availability: InStock
Rating: 5 (16 reviews)

Cat.No.S4686

Vitamin E (D-alpha-Tocopherol) is a fat-soluble vitamin with potent antioxidant properties. It is a potent peroxyl radical scavenger and inhibits noncompetitively cyclooxygenase activity in many tissues, also inhibits angiogenesis and tumor dormancy through suppressing vascular endothelial growth factor (VEGF) gene transcription.

Chemical Structure

Molecular Weight: 430.71

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Quality Control

Batch: Purity: 100.00%

100.00

Related Targets	Adrenergic Receptor AChR 5-HT Receptor Calcium Channel Histamine Receptor Dopamine Receptor GABA Receptor TRP Channel Cholinesterase (ChE) GluR
Other COX Inhibitors	NS-398 (NS398) Paeoniflorin (NSC 178886) Xanthohumol Lumiracoxib Bufexamac Ginsenoside Rd Etoricoxib Oroxin B Nimesulide (-)-Epicatechin gallate

Solubility

In vitro
Batch:

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	4.300mg/ml (9.98mM)	Taking the 1 mL working solution as an example, add 50 μL of 86 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	4.300mg/ml (9.98mM)	Taking the 1 mL working solution as an example, add 50 μL of 86 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	7.500mg/ml (17.41mM)	Taking the 1 mL working solution as an example, add 50 μL of 150 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	430.71	Formula	C₂₉H₅₀O₂	Storage (From the date of receipt)	2 years -20°C liquid
CAS No.	59-02-9	Download SDF		Storage (From the date of receipt)	2 years -20°C liquid

Read more about storage stability stock solution CAS number

Mechanism of Action

Targets/IC₅₀/Ki	COX VEGFR
In vitro	this compound is capable of inducing necrosis in TC-1 cells and has antioxidant effects against nitric oxide.
In vivo	Vitamin E induces TC-1 cell necrosis in vivo and reduces tumor volume in TC-1 tumor-bearing mice. This compound reduces myeloid derived suppressor cells(MDSCs) in tumors of TC-1 tumor-bearing mice and enhances T cell accumulation.
References	[1] https://pubmed.ncbi.nlm.nih.gov/25072795/ [2] https://pubmed.ncbi.nlm.nih.gov/11160566/ [3] https://pubmed.ncbi.nlm.nih.gov/12069504/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2025-12-03)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT05175300	RECRUITING	Hip Arthropathy	GCS Ramsay Santé pour l'Enseignement et la Recherche	2023-03-24
NCT07303803	RECRUITING	MASH - Metabolic Dysfunction-Associated Steatohepatitis; T2DM (Type 2 Diabetes Mellitus)	Shanghai Jiao Tong University School of Medicine	2026-01-01	PHASE2
NCT07668284	NOT_YET_RECRUITING	Prostate Cancer; Uterine Cancer; Cervical Cancer; Anal Cancer	University of Nebraska	2026-07-01	PHASE1; PHASE2
NCT07715890	NOT_YET_RECRUITING	Lipid Metabolism Disorders	National Heart, Lung, and Blood Institute (NHLBI)	2026-09-09
NCT07796204	NOT_YET_RECRUITING	Obesity; Type 2 Diabetes	Pennington Biomedical Research Center	2026-09-03
NCT07781514	ENROLLING_BY_INVITATION	Hypothyroidism	Bangladesh Medical University	2027-02

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