Vitamin E

For research use only.

Catalog No.S4686 Synonyms: Alpha-Tocopherol, D-alpha-Tocopherol, 5,7,8-Trimethyltocol|(+)-alpha-Tocopherol

3 publications

Vitamin E Chemical Structure

CAS No. 59-02-9

Vitamin E (D-alpha-Tocopherol) is a fat-soluble vitamin with potent antioxidant properties. It is a potent peroxyl radical scavenger and inhibits noncompetitively cyclooxygenase activity in many tissues, also inhibits angiogenesis and tumor dormancy through suppressing vascular endothelial growth factor (VEGF) gene transcription.

Selleck's Vitamin E has been cited by 3 publications

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Biological Activity

Description Vitamin E (D-alpha-Tocopherol) is a fat-soluble vitamin with potent antioxidant properties. It is a potent peroxyl radical scavenger and inhibits noncompetitively cyclooxygenase activity in many tissues, also inhibits angiogenesis and tumor dormancy through suppressing vascular endothelial growth factor (VEGF) gene transcription.
Targets
COX [2]
()
VEGFR [3]
()
In vitro

vitamin E is capable of inducing necrosis in TC-1 cells and has antioxidant effects against nitric oxide[1].

In vivo

Vitamin E induces TC-1 cell necrosis in vivo and reduces tumor volume in TC-1 tumor-bearing mice. Vitamin E reduces myeloid derived suppressor cells(MDSCs) in tumors of TC-1 tumor-bearing mice and enhances T cell accumulation[1].

Protocol

Cell Research:

[1]

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  • Cell lines: TC-1 cells
  • Concentrations: 0, 25, 50 μM
  • Incubation Time: 18 h
  • Method:

    For in vitro cytotoxicity experiments, 1×105 TC-1 cells per well are added to 24-well plates. Eighteen hours later, tumor cells are treated with Vitamin E (0, 25, 50 μM). After 18 hours, apoptotic (Annexin V+ and 7AAD−) and necrotic (Annexin V+ and 7AAD+) cells are measured using PE Annexin V Apoptosis Detection Kit I.


    (Only for Reference)
Animal Research:

[1]

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  • Animal Models: C57BL/6 mice 
  • Dosages: 2 mg/kg
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

Chemical Information

Molecular Weight 430.71
Formula

C29H50O2

Density 0.95 g/mL at 25 °C
CAS No. 59-02-9
Storage 2 years -20°C liquid
Synonyms Alpha-Tocopherol, D-alpha-Tocopherol, 5,7,8-Trimethyltocol|(+)-alpha-Tocopherol
Smiles CC1=C(C2=C(CCC(O2)(C)CCCC(C)CCCC(C)CCCC(C)C)C(=C1O)C)C

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04315311 Not yet recruiting Drug: CREON Exocrine Pancreatic Insufficiency (EPI) AbbVie February 28 2022 Phase 4

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID