Home Metabolism PDE inhibitor Theobromine For research use only.

Theobromine

Synonyms: 3,7-Dimethylxanthine

Theobromine (3,7-Dimethylxanthine) is a xanthine alkaloid widely consumed as stimulants and snacks in coffee and cocoa based foods and most often as part of ingredients in drugs.

Theobromine Chemical Structure

Theobromine Chemical Structure

CAS: 83-67-0

Purity & Quality Control

Batch: S236801 0.5MNAOH] 4.32 mg/mL] false] DMSO] Insoluble] false] Water] Insoluble] false Purity: 99.83%
99.83

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Biological Activity

Description Theobromine (3,7-Dimethylxanthine) is a xanthine alkaloid widely consumed as stimulants and snacks in coffee and cocoa based foods and most often as part of ingredients in drugs.
In vitro
In vitro

Theobromine (3,7-Dimethylxanthine) is a xanthine alkaloid that is used as a bronchodilator and as a vasodilator. [1] It has a weaker diuretic activity than theophylline and is also a less powerful stimulant of smooth muscle. [2] Unlike caffeine, Theobromine has practically no stimulant effect on the central nervous system. In contrast, It may improve mood and cognition via peripheral physiological changes. [3] It was formerly used as a diuretic and in the treatment of angina pectoris and hypertension. [4]
In Vivo
In vivo

LD50: Rabbits >200mg/kg (i.g.) [5]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01659060 Completed
Hypertension Pregnancy-induced
Laval University
 July 2008 Phase 2

Chemical Information & Solubility

Molecular Weight 180.16 Formula

C7H8N4O2
CAS No. 83-67-0 SDF Download Theobromine SDF
Smiles CN1C=NC2=C1C(=O)NC(=O)N2C
Storage (From the date of receipt)

In vitro
Batch:

0.5MNAOH : 4.32 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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