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CAS No. 82854-37-3
Echinacoside, a natural polyphenolic compound, has various biological activities, such as antioxidative, anti-inflammatory, neuroprotective, hepatoprotective, nitric oxide radical-scavenging and vasodilative actions. Echinacoside, one of the phenylethanoids isolated from the stems of Cistanche salsa, elicits neuroprotection by activating Trk receptors and their downstream signal pathways. Echinacoside also has a remarkable antiosteoporotic activity.
Selleck's Echinacoside has been cited by 1 publication
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|Description||Echinacoside, a natural polyphenolic compound, has various biological activities, such as antioxidative, anti-inflammatory, neuroprotective, hepatoprotective, nitric oxide radical-scavenging and vasodilative actions. Echinacoside, one of the phenylethanoids isolated from the stems of Cistanche salsa, elicits neuroprotection by activating Trk receptors and their downstream signal pathways. Echinacoside also has a remarkable antiosteoporotic activity.|
Echinacoside behaves in vitro as an anti-oxidant and a potent free radical scavenger. It has been shown to rescue SH-SY5Y neuronal cells from TNF-alpha-induced apoptosis. Echinacoside significantly attenuates glutamate-induced neurotoxicity and exhibits neuroprotective activities in vitro. Echinacoside has significant neuroprotective effects on TNFα-induced apoptosis in SHSY5Y neuronal cells by maintaining mitochondrial function, decreasing the generation of reactive oxygen species, increasing the expression of the antiapoptotic protein Bcl-2 and inhibiting caspase-3 activity through an antioxidation mechanism.
|In vivo||Echinacoside has neuroprotective effects in the mouse MPTP model of Parkinson's disease. Treatment with echinacoside improves motor behavior and attenuated the depletion of striatal dopamine, DOPAC and HVA in MPTP-lesioned mice.|
|In vitro||DMSO||100 mg/mL (127.1 mM)|
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