research use only

Sesamin

Name: Sesamin
Brand: Selleck Chemicals
SKU: S2392
Availability: InStock
Rating: 5 (5 reviews)

Cat.No.S2392

Sesamin (Fagarol, Fsesamin), a lignan isolated from the bark of Fagara plants and from sesame oil, exhibits various health benefits.

Chemical Structure

Molecular Weight: 354.35

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability

Quality Control

Batch: Purity: 99.86%

99.86

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Chemical Information, Storage & Stability

Molecular Weight	354.35	Formula	C₂₀H₁₈O₆	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	607-80-7	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	Fagarol, Fsesamin			Smiles	C1C2C(COC2C3=CC4=C(C=C3)OCO4)C(O1)C5=CC6=C(C=C5)OCO6

Solubility

In vitro
Batch:

DMSO : 71 mg/mL ( (200.36 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
=	×	×

Dilution Calculator Molecular Weight Calculator

In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

In vitro	Sesamin (Fagarol) is a lignan isolated from the bark of Fagara plants and from sesame oil. It has been used as a dietary fat-reduction supplement. This compound truly increases fat metabolism. It specifically inhibits delta 5 desaturase at low concentrations in polyunsaturated fatty acid biosynthesis in both microorganisms and animals, but does not inhibit delta 6, delta 9 and delta 12 desaturases. ^[1] Dietary sesamin greatly increases the hepatic activity of fatty acid oxidation enzymes, including carnitine palmitoyltransferase, acyl-CoA dehydrogenase, acyl-CoA oxidase, 3-hydroxyacyl-CoA dehydrogenase, enoyl-CoA hydratase, and 3-ketoacyl-CoA thiolase. This compound also increases the activity of 2,4-dienoyl-CoA reductase and delta3,delta2-enoyl-CoA isomerase, enzymes involved in the auxiliary pathway for beta-oxidation of unsaturated fatty acids dose-dependently. ^[2] It is also a novel inhibitor of pregnane X receptor (PXR) and may be useful for modulating CYP3A4 and drug efficacies. ^[3]
In vivo	LD50: Mice 3800mg/kg (i.g.); Rats 6150mg/kg (i.g.) ^[4]
References	https://pubmed.ncbi.nlm.nih.gov/1943494/ https://pubmed.ncbi.nlm.nih.gov/10535395/ https://pubmed.ncbi.nlm.nih.gov/22645625/ http://link.springer.com/chapter/10.1007%2F978-1-4020-8804-9_14#

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT05678439	Recruiting	Sleeping Disorders	Taipei Medical University	November 18 2022	Not Applicable

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