Sesamin

Catalog No.S2392 Synonyms: Fagarol, Fsesamin

Sesamin Chemical Structure

Molecular Weight(MW): 354.35

Sesamin, a lignan isolated from the bark of Fagara plants and from sesame oil, exhibits various health benefits.

Size Price Stock Quantity  
In DMSO USD 160 In stock
USD 110 In stock
USD 170 In stock
USD 570 In stock
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Biological Activity

Description Sesamin, a lignan isolated from the bark of Fagara plants and from sesame oil, exhibits various health benefits.
In vitro

Sesamin (Fagarol) is a lignan isolated from the bark of Fagara plants and from sesame oil. It has been used as a dietary fat-reduction supplement. Sesamin truly increases fat metabolism. Sesamin specifically inhibits delta 5 desaturase at low concentrations in polyunsaturated fatty acid biosynthesis in both microorganisms and animals, but does not inhibit delta 6, delta 9 and delta 12 desaturases. [1] Dietary sesamin greatly increases the hepatic activity of fatty acid oxidation enzymes, including carnitine palmitoyltransferase, acyl-CoA dehydrogenase, acyl-CoA oxidase, 3-hydroxyacyl-CoA dehydrogenase, enoyl-CoA hydratase, and 3-ketoacyl-CoA thiolase. Dietary sesamin also increases the activity of 2,4-dienoyl-CoA reductase and delta3,delta2-enoyl-CoA isomerase, enzymes involved in the auxiliary pathway for beta-oxidation of unsaturated fatty acids dose-dependently. [2] Sesamin is also a novel inhibitor of pregnane X receptor (PXR) and may be useful for modulating CYP3A4 and drug efficacies. [3]

In vivo LD50: Mice 3800mg/kg (i.g.); Rats 6150mg/kg (i.g.) [4]

Protocol

Solubility (25°C)

In vitro DMSO 70 mg/mL warmed (197.54 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 354.35
Formula

C20H18O6

CAS No. 607-80-7
Storage powder
in solvent
Synonyms Fagarol, Fsesamin

Bio Calculators

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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