Ursolic Acid

Catalog No.S2370 Synonyms: NSC 167406, NSC-4060, Prunol, Urson, Malol

For research use only.

Ursolic acid (NSC 167406, NSC-4060, Prunol, Urson, Malol) is a pentacyclic triterpene acid, used in cosmetics.

Ursolic Acid Chemical Structure

CAS No. 77-52-1

Selleck's Ursolic Acid has been cited by 6 Publications

Purity & Quality Control

Related Other Products

Biological Activity

Description Ursolic acid (NSC 167406, NSC-4060, Prunol, Urson, Malol) is a pentacyclic triterpene acid, used in cosmetics.
In vitro

Ursolic acid(Malol) is a pentacyclic triterpene acid, used in cosmetics, that is also capable of inhibiting various types of cancer cells by inhibiting the STAT3 activation pathway and human fibrosarcoma cells by reducing the expression of matrix metalloproteinase-9 by acting through the glucocorticoid receptor. As medicine, it is well tolerated and can be used topically and orally. Ursolic acid can also serve as a starting material for synthesis of more potent bioactive derivatives, such as anti-tumor agents. [1]

Methods Test Index PMID
Western blot p-AKT / MDM2 / TOPK / p-TOPK ; p21 ; KRAS(G12V) / p-B-Raf / B-Raf / p-MEK / MEK / p-ERK / ERK ; p-IKKα / IKKα / p-IκBα / IκBα / p-p65 / p65 ; p-NF-κB / NF-κB ; E-cadherin / Vimentin / N-cadherin / Twist / β-catenin / p-GSK3β / Cyclin D1 26582056 27472952 28090191
Growth inhibition assay Cell viability 27472952

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 91 mg/mL
(199.25 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 456.7


CAS No. 77-52-1
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1CCC2(CCC3(C(=CCC4C3(CCC5C4(CCC(C5(C)C)O)C)C)C2C1C)C)C(=O)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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