Skatole

For research use only.

Catalog No.S4959 Synonyms: 3-methylindole, Scatole

Skatole Chemical Structure

CAS No. 83-34-1

Skatole (3-methylindole, Scatole) is a mildly toxic white crystalline organic compound that occurs naturally in feces. It has a fairly broad bacteriostatic effect.

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Biological Activity

Description Skatole (3-methylindole, Scatole) is a mildly toxic white crystalline organic compound that occurs naturally in feces. It has a fairly broad bacteriostatic effect.
In vivo 3MI causes pulmonary edema in goats, sheep, rats, and some strains of mice. Response to 3-methylindole (3MI) varies among species. Mice recover from 3MI-induced bronchiolar epithelial injury but sustain persistent olfactory mucosal injury with scarring and epithelial metaplasia. In contrast, 3MI induces obliterative bronchiolitis in horses and ponies. It also causes severe olfactory mucosal damage and fibrosis in rodents (in addition to small airways disease)[2].

Protocol

Cell Research:

[1]

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  • Cell lines: Pig hepatocytes
  • Concentrations: 0.5 mM
  • Incubation Time: 24 h
  • Method:

    Cells were pre-incubated for 24 h prior to addition of acetone or skatole. A total of 17 mM acetone or 0.5 mM skatole (final concentration) were added and cells were incubated for further 24 h. Control cells were treated similarly except that no acetone or skatole was added.


    (Only for Reference)
Animal Research:

[2]

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  • Animal Models: Fifteen adult grade ponies (aged 2 to approximately 20 years; mean weight, 177.1 kg)
  • Dosages: 100 mg/kg
  • Administration: nasogastric intubation
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 26 mg/mL (198.21 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 131.17
Formula

C9H9N

CAS No. 83-34-1
Storage powder
in solvent
Synonyms 3-methylindole, Scatole
Smiles CC1=CNC2=CC=CC=C12

In vivo Formulation Calculator (Clear solution)

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Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

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Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

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Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID