Skatole

Catalog No.S4959 Synonyms: 3-methylindole, Scatole

For research use only.

Skatole (3-methylindole, Scatole) is a mildly toxic white crystalline organic compound that occurs naturally in feces. It has a fairly broad bacteriostatic effect.

Skatole Chemical Structure

CAS No. 83-34-1

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Biological Activity

Description Skatole (3-methylindole, Scatole) is a mildly toxic white crystalline organic compound that occurs naturally in feces. It has a fairly broad bacteriostatic effect.
In vivo 3MI causes pulmonary edema in goats, sheep, rats, and some strains of mice. Response to 3-methylindole (3MI) varies among species. Mice recover from 3MI-induced bronchiolar epithelial injury but sustain persistent olfactory mucosal injury with scarring and epithelial metaplasia. In contrast, 3MI induces obliterative bronchiolitis in horses and ponies. It also causes severe olfactory mucosal damage and fibrosis in rodents (in addition to small airways disease)[2].

Protocol (from reference)

Cell Research:

[1]

  • Cell lines: Pig hepatocytes
  • Concentrations: 0.5 mM
  • Incubation Time: 24 h
  • Method:

    Cells were pre-incubated for 24 h prior to addition of acetone or skatole. A total of 17 mM acetone or 0.5 mM skatole (final concentration) were added and cells were incubated for further 24 h. Control cells were treated similarly except that no acetone or skatole was added.

Animal Research:

[2]

  • Animal Models: Fifteen adult grade ponies (aged 2 to approximately 20 years; mean weight, 177.1 kg)
  • Dosages: 100 mg/kg
  • Administration: nasogastric intubation

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 131.17
Formula

C9H9N

CAS No. 83-34-1
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1=CNC2=CC=CC=C12

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