TGF-beta/Smad compound library

Catalog No.L5600

Offered in 96 or 384 well plate format

A unique collection of 105 small molecules with biological activity used for TGF-beta/Smad pathway research.

Selleck Chemicals compound library contributes and expedites
the investigation of treatments against COVID19

The researchers at the National Institute of Infectious Diseases, in Japan, successfully found anti-COVID19 drugs within 3 months of
screening FDA-approved drug library from Selleck Chemicals. They have already published this article doi: 10.1101/2020.04.14.039925.

Recently the accomplishment of this research, using Selleck Chemicals library, was reported on Japanese television

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Specific Compounds Quantities Plate Map Dry/solid or DMSO solution

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TGF-beta/Smad compound library Contents

Download the TGF-beta/Smad compound library - SDF

Download the TGF-beta/Smad compound library - XLSX

Download the Compound Library Usage Instructions-pdf

Cited by 82 Publications

Cell Metab,2019,7;29(5):1166-1181.e6.

PubMed: 30799286 ( click the link to review the publication )

Nat Med,2014,20(8):954-60

PubMed: 24997607 ( click the link to review the publication )

Nat Commun,2020,14;11(1):1792.

PubMed: 32286289 ( click the link to review the publication )

Cancer Res,2020,15;80(4):832-842.

PubMed: 31888889 ( click the link to review the publication )

Stem Cell Reports,2020,14(3):478-492

PubMed: 32084387 ( click the link to review the publication )

Cancer Lett,2020,469:195-206

PubMed: 31672491 ( click the link to review the publication )

Cell Death Dis,2020,2;11(3):158.

PubMed: 32123161 ( click the link to review the publication )

Signal Transduct Target Ther,2020,4;5:20.

PubMed: 32195002 ( click the link to review the publication )

Mol Ther Oncolytics,2020,30;17:169-179.

PubMed: 32346607 ( click the link to review the publication )

Cell Chem Biol,2020,20;27(2):197-205.e6.

PubMed: 31734178 ( click the link to review the publication )

Cell Chem Biol,2020,16;27(1):94-104.e5.

PubMed: 31902676 ( click the link to review the publication )

Antimicrob Agents Chemother,2020,4;AAC.02523-19.

PubMed: 32366713 ( click the link to review the publication )

Toxicol Sci,2020,1;174(2):218-240.

PubMed: 32040181 ( click the link to review the publication )

Int J Mol Sci,2020,18;21(8):2825.

PubMed: 32325639 ( click the link to review the publication )

Sci Rep,2020,24;10(1):5318.

PubMed: 32210281 ( click the link to review the publication )

J Biol Chem,2020,27;jbc.RA120.012981.

PubMed: 32461254 ( click the link to review the publication )

Breast Cancer Res Treat,2020,179(2):337-347.

PubMed: 31655920 ( click the link to review the publication )

PLoS One,2020,15(1):e0228189

PubMed: 31999754 ( click the link to review the publication )

J Allergy Clin Immunol,2020,21;S0091-6749(20)30259-1.

PubMed: 32088305 ( click the link to review the publication )

bioRxiv,2020,doi:10.1101/421354

PubMed: no ( click the link to review the publication )

bioRxiv,2020,doi:10.1101/2020.05.26.117770

PubMed: No ( click the link to review the publication )

Genome Biol,2019,20(1):253

PubMed: 31771620 ( click the link to review the publication )

Sci Adv,2019,5(6):eaav9784

PubMed: 31249867 ( click the link to review the publication )

Cell Rep,2019,5;26(6):1544-1556.e8.

PubMed: 30726737 ( click the link to review the publication )
Neuropsychopharmacology,2019,10.1038/s41386-018-0266-7

PubMed: 30518933 ( click the link to review the publication )

Cancers (Basel),2019,30;11(2):156.

PubMed: 30704052 ( click the link to review the publication )

Breast Cancer Res,2019,21(1):37

PubMed: 30845991 ( click the link to review the publication )

Cell Chem Biol,2019,21;26(2):235-243.e5.

PubMed: 30527999 ( click the link to review the publication )

Neurobiol Aging,2019,76:24-34

PubMed: 30640040 ( click the link to review the publication )

Cancer Gene Ther,2019,10.1038/s41417-019-0127-5

PubMed: 31383953 ( click the link to review the publication )

Stem Cells Int,2019,2019:3435901

PubMed: 31871467 ( click the link to review the publication )

Cancer Manag Res,2019,11:8391-8405

PubMed: 31571995 ( click the link to review the publication )

Breast Cancer Res Treat,2019,10.1007/s10549-019-05504-5

PubMed: 31784862 ( click the link to review the publication )

Acta Pharmacol Sin,2019,10.1038/s41401-019-0246-4

PubMed: 31197246 ( click the link to review the publication )

Cell Signal,2019,67:109508

PubMed: 31866490 ( click the link to review the publication )

Virology,2019,541:41-51

PubMed: 31826845 ( click the link to review the publication )

Int J Parasitol Drugs Drug Resist,2019,10:28-37.

PubMed: 31015150 ( click the link to review the publication )

J Med Virol,2019,91(8):1440-1447.

PubMed: 30900754 ( click the link to review the publication )

Bioengineered,2019,10(1):98-107

PubMed: 31023186 ( click the link to review the publication )

Kaohsiung J Med Sci,2019,10.1002/kjm2.12051

PubMed: 30896891 ( click the link to review the publication )

Nat Commun,2018,9(1):1655

PubMed: 29695808 ( click the link to review the publication )

Cell Rep,2018,22(5):1185-1199

PubMed: 29386107 ( click the link to review the publication )

EBioMedicine,2018,28:80-89.

PubMed: 29396295 ( click the link to review the publication )

Cancer Sci,2018,109(4):1220-1229

PubMed: 29453896 ( click the link to review the publication )

Sci Rep,2018,8(1):13106

PubMed: 30166612 ( click the link to review the publication )

Sci Rep,2018,21;8(1):14178.

PubMed: 30242186 ( click the link to review the publication )

J Cell Physiol,2018,233(1):422-433

PubMed: 28294327 ( click the link to review the publication )

Oncotarget,2018,9(57):31018-31031

PubMed: 30123424 ( click the link to review the publication )
Methods Mol Biol,2018,1795:203-221.

PubMed: 29846930 ( click the link to review the publication )

Nat Commun,2017,17;8:16078.

PubMed: 28714472 ( click the link to review the publication )

Lab Chip,2017,31;17(3):511-520.

PubMed: 28092382 ( click the link to review the publication )

Anal Chem,2017,89(12):6678-6685

PubMed: 28520400 ( click the link to review the publication )

Antimicrob Agents Chemother,2017,62(1)

PubMed: 29061736 ( click the link to review the publication )

PLoS One,2017,5;12(1):e0169407.

PubMed: 28056055 ( click the link to review the publication )

Parasitol Res,2017,116(10):2619-2626.

PubMed: 28776226 ( click the link to review the publication )

Biol Pharm Bull,2017,40(8):1289-1298.

PubMed: 28769010 ( click the link to review the publication )

Pharmacol Res,2016,113(Pt A):216-227

PubMed: 27543462 ( click the link to review the publication )

Biogerontology,2016,17(5-6):907-920.

PubMed: 27484416 ( click the link to review the publication )

PLoS One,2016,11(2):e0149848

PubMed: 26919709 ( click the link to review the publication )

Sensors (Basel),2016,16(3)

PubMed: 26999137 ( click the link to review the publication )

Database (Oxford),2016,7;2016:baw041.

PubMed: 27055828 ( click the link to review the publication )

Genome Biol,2015,19;16(1):127.

PubMed: 26084335 ( click the link to review the publication )

Clin Cancer Res,2015,21(5):1172-82

PubMed: 25549722 ( click the link to review the publication )

Biosens Bioelectron,2015,68:699-704

PubMed: 25668591 ( click the link to review the publication )

Cancer Discov,2015,5(2):154-67.

PubMed: 25501949 ( click the link to review the publication )

Mol Cancer Ther,2015,14(5):1213-23

PubMed: 25777964 ( click the link to review the publication )

Cell Cycle,2015,14(1):109-22

PubMed: 25602521 ( click the link to review the publication )

PLoS One,2015,10(11):e0142655

PubMed: 26569102 ( click the link to review the publication )

Oncotarget,2015,6(3):1531-43

PubMed: 25605238 ( click the link to review the publication )

Head Neck,2015,37(12):1722-32

PubMed: 24986420 ( click the link to review the publication )

Mol Cancer Res,2014,12(5):703-13

PubMed: 24554781 ( click the link to review the publication )

Oncotarget,2014,5(15):6512-25

PubMed: 25156567 ( click the link to review the publication )
Curr Protoc Chem Biol,2014,4:177-191

PubMed: 26705509 ( click the link to review the publication )

Case Studies using Selleck Compound Libraries

Application of GPCR Compound Library in liver cancer (This article was published in Nature (IF=43) and took about 15 months):
Nature.2019;574(7777):268-272
Application of Kinase Inhibitor Library in colorectal cancer (This article was published in Nature Communications (IF=11) and took about 8 months):
Nat Commun. 2019 16;10(1):2197
Application of FDA-approved Drug Library in antivirus (This article was published in Cell Research (IF=17) and took about 13 months):
Cell Res. 2019;29(9):739-753
Application of FDA-approved Drug Library in metabolism (This article was published in Movement Disorders (IF=8) and took about 10 months):
Mov Disord. 2019;34(3):323-334
Application of Epigenetics Compound Library in acute lymphoblastic leukemia (This article was published in Blood (IF=16) and took about 16 months):
Blood. 2019 17;134(16):1323-1336
Application of Inhibitor Library in tumor immunology (This article was published in Cancer Immunol Res (IF=8.6) and took about 12 months):
Cancer Immunol Res.2017;5(9):790-803

Description & Advantages

• A unique collection of 105 small molecule compounds for high throughput screening(HTS) and high content screening (HCS).

• Target includes TGF-beta/Smad,TGF-β Receptor,PKC, ROCK and RAS

• A useful tool for finding tumor therapeutic mechanism and new targets.

• For studying human diseases, exploring the pathogenesis of diseases such as cancer, and opening noval therapeutic ways.

• Structurally diverse, medicinally active, and cell permeable.

• Rich documentation with structure description, target information, IC₅₀ values and customer reviews.

• NMR and HPLC validated to ensure high purity.

Product Details

Formulation:	100 compounds pre-dissolved in 10mM DMSO, 2 compounds pre-dissolved in 10mM water and 3 compounds pre-dissolved in 2mM DMSO
Container:	96 Well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
Stability:	12 months -20°C in DMSO
Stability:	24 months -80°C in DMSO
Shipping:	Blue ice or dry ice
Packaging:	Inert gas

TGF-beta/Smad compound library Composition

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