TGF-beta/Smad compound library

Catalog No.L5600

Offered in 96 or 384 well plate format

A unique collection of 135 small molecules with biological activity used for TGF-beta/Smad pathway research.

Selleck Chemicals compound library contributes and expedites
the investigation of treatments against COVID19

The researchers at the National Institute of Infectious Diseases, in Japan, successfully found anti-COVID19 drugs within 3 months of
screening FDA-approved drug library from Selleck Chemicals. They have already published this article doi: 10.1101/2020.04.14.039925.

Recently the accomplishment of this research, using Selleck Chemicals library, was reported on Japanese television

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Specific Compounds Quantities Plate Map Dry/solid or DMSO solution

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TGF-beta/Smad compound library Contents

Download the TGF-beta/Smad compound library - SDF

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Download the Compound Library Usage Instructions-pdf

Cited by 167 Publications

Cell,2020,181(7):1518-1532.e14

PubMed: 32497502 ( click the link to review the publication )

Cell Metab,2019,7;29(5):1166-1181.e6.

PubMed: 30799286 ( click the link to review the publication )

Nature,2017,546(7659):533-538

PubMed: 28614297 ( click the link to review the publication )

Nat Med,2014,20(8):954-60

PubMed: 24997607 ( click the link to review the publication )

J Am Chem Soc,2021,143(13):4979-4992

PubMed: 33761747 ( click the link to review the publication )

Sci Adv,2021,7(10)eabe7853

PubMed: 33674313 ( click the link to review the publication )

Nat Chem Biol,2021,10.1038/s41589-021-00751-4

PubMed: 33686292 ( click the link to review the publication )

Nat Commun,2021,12(1):1117

PubMed: 33602919 ( click the link to review the publication )

Clin Cancer Res,2021,clincanres.4037.2020

PubMed: 33547197 ( click the link to review the publication )

Proc Natl Acad Sci U S A,2021,118(13)e2009620118

PubMed: 33762304 ( click the link to review the publication )

Cell Rep,2021,35(1):108940

PubMed: 33784499 ( click the link to review the publication )

Cell Rep,2021,35(1):108959

PubMed: 33811811 ( click the link to review the publication )

J Exp Clin Cancer Res,2021,40(1):90

PubMed: 33676554 ( click the link to review the publication )

Cancers (Basel),2021,13(3)576

PubMed: 33540838 ( click the link to review the publication )

Clin Epigenetics,2021,13(1):54

PubMed: 33691794 ( click the link to review the publication )

Cell Death Dis,2021,12(2):183

PubMed: 33589588 ( click the link to review the publication )

Acta Pharm Sin B,2021,11(1):181-202

PubMed: 33532188 ( click the link to review the publication )

Mol Cancer Ther,2021,molcanther.MCT-20-0666-E.2020

PubMed: 33850004 ( click the link to review the publication )

Stem Cell Res Ther,2021,12(1):151

PubMed: 33632328 ( click the link to review the publication )

ACS Infect Dis,2021,10.1021/acsinfecdis.0c00853

PubMed: 33599488 ( click the link to review the publication )

Am J Cancer Res,2021,11(1):215-235

PubMed: 33520370 ( click the link to review the publication )

J Immunol,2021,ji2000969

PubMed: 33568399 ( click the link to review the publication )

Int J Mol Sci,2021,22(4)1750

PubMed: 33578647 ( click the link to review the publication )

Sci Rep,2021,11(1):4390

PubMed: 33623106 ( click the link to review the publication )
J Biol Chem,2021,jbc.RA120.016477

PubMed: 33397709 ( click the link to review the publication )

Methods,2021,S1046-2023(21)00015-3

PubMed: 33453392 ( click the link to review the publication )

J Gastroenterol Hepatol,2021,10.1111/jgh.15490

PubMed: 33721913 ( click the link to review the publication )

Pathogens,2021,10(2)253

PubMed: 33672424 ( click the link to review the publication )

Hum Cell,2021,10.1007/s13577-021-00497-0

PubMed: 33555519 ( click the link to review the publication )

Hum Cell,2021,10.1007/s13577-021-00497-0

PubMed: 33611700 ( click the link to review the publication )

FEBS Open Bio,2021,11(5):1452-1464

PubMed: 33822489 ( click the link to review the publication )

J Toxicol Sci,2021,46(4):167-176

PubMed: 33814510 ( click the link to review the publication )

In Vivo,2021,35(2):761-777

PubMed: 33622869 ( click the link to review the publication )

STAR Protoc,2021,2(1):100345

PubMed: 33665625 ( click the link to review the publication )

AAPS J,2021,23(2):35

PubMed: 33649974 ( click the link to review the publication )

Genes Cancer,2021,12:12-24

PubMed: 33884102 ( click the link to review the publication )

Nat Commun,2020,14;11(1):1792.

PubMed: 32286289 ( click the link to review the publication )

Nucleic Acids Res,2020,48(20):11566-11576

PubMed: 33053158 ( click the link to review the publication )

Cancer Res,2020,15;80(4):832-842.

PubMed: 31888889 ( click the link to review the publication )

Cell Rep,2020,32(1):107845

PubMed: 32640215 ( click the link to review the publication )

EBioMedicine,2020,60:102988

PubMed: 32927276 ( click the link to review the publication )

Stem Cell Reports,2020,14(3):478-492

PubMed: 32084387 ( click the link to review the publication )

Cancer Lett,2020,469:195-206

PubMed: 31672491 ( click the link to review the publication )

Cancers (Basel),2020,12(6)E1418

PubMed: 32486290 ( click the link to review the publication )

Cell Death Dis,2020,2;11(3):158.

PubMed: 32123161 ( click the link to review the publication )

Cell Death Dis,2020,11(9):724

PubMed: 32895373 ( click the link to review the publication )

Signal Transduct Target Ther,2020,4;5:20.

PubMed: 32195002 ( click the link to review the publication )

Mol Ther Oncolytics,2020,30;17:169-179.

PubMed: 32346607 ( click the link to review the publication )
Cell Chem Biol,2020,20;27(2):197-205.e6.

PubMed: 31734178 ( click the link to review the publication )

Cell Chem Biol,2020,16;27(1):94-104.e5.

PubMed: 31902676 ( click the link to review the publication )

Carcinogenesis,2020,41(7):993-1004

PubMed: 31740922 ( click the link to review the publication )

Antimicrob Agents Chemother,2020,4;AAC.02523-19.

PubMed: 32366713 ( click the link to review the publication )

Toxicol Sci,2020,1;174(2):218-240.

PubMed: 32040181 ( click the link to review the publication )

Int J Mol Sci,2020,18;21(8):2825.

PubMed: 32325639 ( click the link to review the publication )

Sci Rep,2020,24;10(1):5318.

PubMed: 32210281 ( click the link to review the publication )

J Biol Chem,2020,27;jbc.RA120.012981.

PubMed: 32461254 ( click the link to review the publication )

Breast Cancer Res Treat,2020,179(2):337-347.

PubMed: 31655920 ( click the link to review the publication )

PLoS One,2020,15(1):e0228189

PubMed: 31999754 ( click the link to review the publication )

PLoS One,2020,15(5):e0233672

PubMed: 32469945 ( click the link to review the publication )

PLoS One,2020,15(5):e0233089

PubMed: 32459810 ( click the link to review the publication )

J Allergy Clin Immunol,2020,21;S0091-6749(20)30259-1.

PubMed: 32088305 ( click the link to review the publication )

bioRxiv,2020,doi:10.1101/2020.05.26.117770

PubMed: No ( click the link to review the publication )

Sarcoma,2020,2020:6312480

PubMed: 32565715 ( click the link to review the publication )

bioRxiv,2020,2020.04.20.051581

PubMed: 32511378 ( click the link to review the publication )

ACS Pharmacol Transl Sci,2020,3(6):1278-1292

PubMed: 33330842 ( click the link to review the publication )

Genome Biol,2019,20(1):253

PubMed: 31771620 ( click the link to review the publication )

Sci Adv,2019,5(6):eaav9784

PubMed: 31249867 ( click the link to review the publication )

Cell Rep,2019,5;26(6):1544-1556.e8.

PubMed: 30726737 ( click the link to review the publication )

Neuropsychopharmacology,2019,10.1038/s41386-018-0266-7

PubMed: 30518933 ( click the link to review the publication )

Drug Discov Today,2019,24(2):390-402

PubMed: 30399443 ( click the link to review the publication )

Cancers (Basel),2019,30;11(2):156.

PubMed: 30704052 ( click the link to review the publication )

Breast Cancer Res,2019,21(1):37

PubMed: 30845991 ( click the link to review the publication )
Anal Chem,2019,91(8):4995-5003

PubMed: 30813716 ( click the link to review the publication )

Cell Chem Biol,2019,21;26(2):235-243.e5.

PubMed: 30527999 ( click the link to review the publication )

Cancer Discov,2019,9(7):910-925

PubMed: 31048320 ( click the link to review the publication )

Neurobiol Aging,2019,76:24-34

PubMed: 30640040 ( click the link to review the publication )

mSphere,2019,4(3)e00047-19

PubMed: 31118297 ( click the link to review the publication )

Cancer Gene Ther,2019,10.1038/s41417-019-0127-5

PubMed: 31383953 ( click the link to review the publication )

Stem Cells Int,2019,2019:3435901

PubMed: 31871467 ( click the link to review the publication )

Biochem J,2019,476(15):2209-2219

PubMed: 31341008 ( click the link to review the publication )

Cancer Manag Res,2019,11:8391-8405

PubMed: 31571995 ( click the link to review the publication )

Breast Cancer Res Treat,2019,10.1007/s10549-019-05504-5

PubMed: 31784862 ( click the link to review the publication )

Acta Pharmacol Sin,2019,10.1038/s41401-019-0246-4

PubMed: 31197246 ( click the link to review the publication )

Cell Signal,2019,67:109508

PubMed: 31866490 ( click the link to review the publication )

Virology,2019,541:41-51

PubMed: 31826845 ( click the link to review the publication )

Molecules,2019,24(20)E3798

PubMed: 31652525 ( click the link to review the publication )

Int J Parasitol Drugs Drug Resist,2019,10:28-37.

PubMed: 31015150 ( click the link to review the publication )

J Med Virol,2019,91(8):1440-1447.

PubMed: 30900754 ( click the link to review the publication )

Bioengineered,2019,10(1):98-107

PubMed: 31023186 ( click the link to review the publication )

Kaohsiung J Med Sci,2019,10.1002/kjm2.12051

PubMed: 30896891 ( click the link to review the publication )

bioRxiv,2019,doi:10.1101/748129

PubMed: no ( click the link to review the publication )

Curr Protoc Chem Biol,2019,11(2):e64

PubMed: 30816629 ( click the link to review the publication )

Cancer Immunol Res,2019,7(9):1523-1534

PubMed: 31266784 ( click the link to review the publication )

Nat Commun,2018,9(1):1655

PubMed: 29695808 ( click the link to review the publication )

Cancer Res,2018,78(15):4344-4359

PubMed: 29844121 ( click the link to review the publication )

Cancer Res,2018,78(20):5731-5740

PubMed: 30135193 ( click the link to review the publication )
Cell Rep,2018,22(5):1185-1199

PubMed: 29386107 ( click the link to review the publication )

Elife,2018,7e35136

PubMed: 29979149 ( click the link to review the publication )

EBioMedicine,2018,28:80-89.

PubMed: 29396295 ( click the link to review the publication )

Cancer Discov,2018,8(4):498-515

PubMed: 29610289 ( click the link to review the publication )

Cancer Sci,2018,109(4):1220-1229

PubMed: 29453896 ( click the link to review the publication )

PLoS Negl Trop Dis,2018,12(3):e0006326

PubMed: 29522528 ( click the link to review the publication )

Antimicrob Agents Chemother,2018,62(12)e01302-18

PubMed: 30224531 ( click the link to review the publication )

Sci Rep,2018,8(1):13106

PubMed: 30166612 ( click the link to review the publication )

Sci Rep,2018,21;8(1):14178.

PubMed: 30242186 ( click the link to review the publication )

Sci Rep,2018,8(1):12046

PubMed: 30104685 ( click the link to review the publication )

J Cell Physiol,2018,233(1):422-433

PubMed: 28294327 ( click the link to review the publication )

Biochem Biophys Res Commun,2018,495(1):1468-1475

PubMed: 29196261 ( click the link to review the publication )

SLAS Discov,2018,23(2):164-173

PubMed: 28985478 ( click the link to review the publication )

Oncotarget,2018,9(57):31018-31031

PubMed: 30123424 ( click the link to review the publication )

Methods Mol Biol,2018,1795:203-221.

PubMed: 29846930 ( click the link to review the publication )

Methods Mol Biol,2018,1765:333-347

PubMed: 29589319 ( click the link to review the publication )

Oncotarget,2018,9(40):26086-26095

PubMed: 29899844 ( click the link to review the publication )

Oncotarget,2018,9(32):22571-22585

PubMed: 29854299 ( click the link to review the publication )

Nat Commun,2017,17;8:16078.

PubMed: 28714472 ( click the link to review the publication )

Proc Natl Acad Sci U S A,2017,114(36):E7554-E7563

PubMed: 28784769 ( click the link to review the publication )

Cell Rep,2017,20(4):999-1015

PubMed: 28746882 ( click the link to review the publication )

Lab Chip,2017,31;17(3):511-520.

PubMed: 28092382 ( click the link to review the publication )

J Med Chem,2017,60(7):2973-2982

PubMed: 28263602 ( click the link to review the publication )

Anal Chem,2017,89(12):6678-6685

PubMed: 28520400 ( click the link to review the publication )
Mol Cancer Ther,2017,16(12):2656-2667

PubMed: 28878027 ( click the link to review the publication )

Antimicrob Agents Chemother,2017,62(1)

PubMed: 29061736 ( click the link to review the publication )

Sci Rep,2017,7(1):14416

PubMed: 29089548 ( click the link to review the publication )

PLoS One,2017,5;12(1):e0169407.

PubMed: 28056055 ( click the link to review the publication )

SLAS Discov,2017,22(5):507-515

PubMed: 28324660 ( click the link to review the publication )

SLAS Discov,2017,22(5):484-493

PubMed: 28346106 ( click the link to review the publication )

SLAS Discov,2017,22(9):1120-1130

PubMed: 28783477 ( click the link to review the publication )

Parasitol Res,2017,116(10):2619-2626.

PubMed: 28776226 ( click the link to review the publication )

Biol Pharm Bull,2017,40(8):1289-1298.

PubMed: 28769010 ( click the link to review the publication )

PhD School in Cell Biology and Development,2017,1-76

PubMed: None ( click the link to review the publication )

Oncotarget,2017,8(43):73745-73756

PubMed: 29088741 ( click the link to review the publication )

Parasit Vectors,2017,10(1):323

PubMed: 28679424 ( click the link to review the publication )

Oncotarget,2017,8(32):53154-53167

PubMed: 28881801 ( click the link to review the publication )

Methods Cell Biol,2017,138:651-679

PubMed: 28129862 ( click the link to review the publication )

Assay Drug Dev Technol,2017,15(5):198-209

PubMed: 28723269 ( click the link to review the publication )

J Invest Dermatol,2016,136(10):2041-2048

PubMed: 27251789 ( click the link to review the publication )

PLoS Genet,2016,12(9):e1006279

PubMed: 27588951 ( click the link to review the publication )

ACS Infect Dis,2016,2(3):180-186

PubMed: 26998514 ( click the link to review the publication )

Pharmacol Res,2016,113(Pt A):216-227

PubMed: 27543462 ( click the link to review the publication )

J Cyst Fibros,2016,15(3):285-94

PubMed: 26694805 ( click the link to review the publication )

Biogerontology,2016,17(5-6):907-920.

PubMed: 27484416 ( click the link to review the publication )

PLoS One,2016,11(6):e0157497

PubMed: 27362433 ( click the link to review the publication )

PLoS One,2016,11(2):e0149848

PubMed: 26919709 ( click the link to review the publication )

Sensors (Basel),2016,16(3)

PubMed: 26999137 ( click the link to review the publication )
Database (Oxford),2016,7;2016:baw041.

PubMed: 27055828 ( click the link to review the publication )

Oncotarget,2016,7(48):79637-79653

PubMed: 27793034 ( click the link to review the publication )

Curr Protoc Toxicol,2016,69:9.10.1-9.10.26

PubMed: 27479365 ( click the link to review the publication )

Genome Biol,2015,19;16(1):127.

PubMed: 26084335 ( click the link to review the publication )

Clin Cancer Res,2015,21(5):1172-82

PubMed: 25549722 ( click the link to review the publication )

Cancer Res,2015,75(24):5341-54

PubMed: 26627007 ( click the link to review the publication )

Biosens Bioelectron,2015,68:699-704

PubMed: 25668591 ( click the link to review the publication )

Cancer Discov,2015,5(2):154-67.

PubMed: 25501949 ( click the link to review the publication )

Mol Cancer Ther,2015,14(5):1213-23

PubMed: 25777964 ( click the link to review the publication )

Cell Cycle,2015,14(1):109-22

PubMed: 25602521 ( click the link to review the publication )

PLoS One,2015,10(2):e0117246

PubMed: 25659151 ( click the link to review the publication )

PLoS One,2015,10(2):e0116688

PubMed: 25710482 ( click the link to review the publication )

PLoS One,2015,10(11):e0142655

PubMed: 26569102 ( click the link to review the publication )

Oncotarget,2015,6(3):1531-43

PubMed: 25605238 ( click the link to review the publication )

Head Neck,2015,37(12):1722-32

PubMed: 24986420 ( click the link to review the publication )

Assay Drug Dev Technol,2015,13(8):456-65

PubMed: 26383544 ( click the link to review the publication )

Oncotarget,2015,6(34):35247-62

PubMed: 26497213 ( click the link to review the publication )

Mol Cancer Res,2014,12(5):703-13

PubMed: 24554781 ( click the link to review the publication )

PLoS One,2014,9(9):e106784

PubMed: 25198282 ( click the link to review the publication )

Oncotarget,2014,5(15):6512-25

PubMed: 25156567 ( click the link to review the publication )

Curr Protoc Chem Biol,2014,4:177-191

PubMed: 26705509 ( click the link to review the publication )

Assay Drug Dev Technol,2014,12(9-10):514-26

PubMed: 25506801 ( click the link to review the publication )

Oncogenesis,2013,2:e69

PubMed: 24018644 ( click the link to review the publication )

Case Studies using Selleck Compound Libraries

Application of GPCR Compound Library in liver cancer (This article was published in Nature (IF=43) and took about 15 months):
Nature.2019;574(7777):268-272
Application of Kinase Inhibitor Library in colorectal cancer (This article was published in Nature Communications (IF=11) and took about 8 months):
Nat Commun. 2019 16;10(1):2197
Application of FDA-approved Drug Library in antivirus (This article was published in Cell Research (IF=17) and took about 13 months):
Cell Res. 2019;29(9):739-753
Application of FDA-approved Drug Library in metabolism (This article was published in Movement Disorders (IF=8) and took about 10 months):
Mov Disord. 2019;34(3):323-334
Application of Epigenetics Compound Library in acute lymphoblastic leukemia (This article was published in Blood (IF=16) and took about 16 months):
Blood. 2019 17;134(16):1323-1336
Application of Inhibitor Library in tumor immunology (This article was published in Cancer Immunol Res (IF=8.6) and took about 12 months):
Cancer Immunol Res.2017;5(9):790-803

Description & Advantages

• A unique collection of 135 small molecule compounds for high throughput screening(HTS) and high content screening (HCS).

• Target includes TGF-beta/Smad,TGF-β Receptor,PKC, ROCK and RAS

• A useful tool for finding tumor therapeutic mechanism and new targets.

• For studying human diseases, exploring the pathogenesis of diseases such as cancer, and opening noval therapeutic ways.

• Structurally diverse, medicinally active, and cell permeable.

• Rich documentation with structure description, target information, IC₅₀ values and customer reviews.

• NMR and HPLC validated to ensure high purity.

Product Details

Formulation:	130 compounds pre-dissolved in 10mM DMSO, 2 compounds pre-dissolved in 10mM water and 3 compounds pre-dissolved in 2mM DMSO
Container:	96 Well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
Stability:	12 months -20°C in DMSO
Stability:	24 months -80°C in DMSO
Shipping:	Blue ice or dry ice

TGF-beta/Smad compound library Composition

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A unique collection of 107 gut microbial metabolites used for high throughput screening(HTS) and high content screening(HCS).
HIF-1 Signaling Pathway Compound Library

A unique collection of 447 HIF-1 signaling pathway compounds used for oxygen sensing related research.
Highly Selective Inhibitor Library

A unique collection of 462 validated highly selective inhibitors with covering over 123 targets.
Histone modification compound library

A unique collection of 245 small molecule compounds with biological activity used for histone modification research and associated assays.
HTS Library for Drug Discovery

A unique collection of 99040 compounds features numerous structurally diverse compounds and several alternate compositions.
Human Hormone Related Compound Library

A unique collection of 479 human hormone related compounds used for high throughput screening(HTS) and high content screening(HCS).
Immunology/Inflammation Compound Library

A unique collection of 2792 small molecules with biological activity used for Immunology/Inflammation research and associated assays.
Inhibitor Library

A unique collection of 4174 inhibitors for high throughput screening (HTS) and high content screening (HCS).
Ion Channel Ligand Library

A unique collection of 231 small molecule modulators used for Ion channel research.
JAK/STAT compound library

A unique collection of 184 small molecules used for research in JAK-STAT signaling pathway.
Lipid Metabolism Compound Library

A unique collection of 427 lipid metabolism related compounds used for high throughput screening(HTS) and high content screening(HCS).
Macrocyclic Compound Library

A unique collection of 188 macrocyclic compounds used for high throughput screening(HTS) and high content screening(HCS).
MAPK Inhibitor Library

A unique collection of 259 small molecule inhibitors used for MAPK signaling research.
Medicine Food Homology Compound Library

A unique collection of 470 medicine food homology compounds used for high throughput screening (HTS) and high content screening (HCS).
Metabolism Compound Library

A unique collection of 2893 small molecules with biological activity in numerous metabolic pathway: glycometabolism, lipid metabolism, proteolysis, etc.
Methylation Compound Library

A unique collection of 112 compounds used for researching the function of methylation in epigenetics,cancer,embryogenesis,etc.
Mouse Metabolite Compound Library

A unique collection of 137 mouse metabolites used for high throughput screening(HTS) and high content screening(HCS).
Natural Organic Compound Library

A unique collection of 1126 plant-derived natural organic compounds used for high throughput screening(HTS) and high content screening(HCS).
Neuronal Signaling Compound Library

A unique collection of 1381 small molecule compounds with biological activity used for neurologic research and associated assays
NF-κB Signaling Compound Library

A unique collection of 429 small molecules used for NF-κB signaling pathway research which plays a key role in immunology/inflammation and cancer.
Nucleoside Analogue Library

A unique collection of 188 nucleoside analogues used for high throughput screening(HTS) and high content screening(HCS).
Obesity Compound Library

A unique collection of 936 compounds used for research in obesity.
Phenotypic Screening Library

A unique collection of 3751 bioactive compounds with identified targets used for phenotypic Screening.
PI3K/Akt Inhibitor Library

A unique collection of 350 small molecule inhibitors used for PI3K/Akt/mTOR pathway research.
Protease Inhibitor Library

A unique collection of 384 small molecule inhibitors used for chemical genomics, high-throughput screening (HTS), and high content screening (HCS).
Protein-protein Interaction Inhibitor Library

A unique collection of 188 protein-protein Interaction(PPI) Inhibitors used for high throughput screening(HTS) and high content screening(HCS).
Pyroptosis Compound Library

A unique collection of 771 pyroptosis related compounds used for high throughput screening(HTS) and high content screening(HCS).
Small Molecule Immuno-Oncology Compound Library

A unique collection of 230 Immuno-Oncology small molecules used for oncotherapy in conjunction with other drugs.
Stem Cell Differentation Compound Library

A unique collection of 250 stem cell differentation related compounds used for high throughput screening(HTS) and high content screening(HCS).
Stem Cell Signaling Compound Library

A unique collection of 814 compounds with biological activity used for stem cell regulatory and signaling pathway research.
Traditional Chinese Medicine Library

A unique collection of 1289 traditional chinese medicine(TCM) monomer compounds used for high throughput screening(HTS) and high content screening(HCS).
Tyrosine Kinase Inhibitor Library

A unique collection of 533 tyrosine kinase inhibitors for high throughput screening (HTS) and high content screening (HCS).
Ubiquitination Compound Library

A unique collection of 198 small molecules for Ubiquitination related research.

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