HomeCompound LibrariesTGF-beta/Smad compound library

TGF-beta/Smad compound library

Catalog No.L5600

Offered in 96 or 384 well plate format

A unique collection of 135 small molecules with biological activity used for TGF-beta/Smad pathway research.

96 well box

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Cited by 224 Publications

TGF-beta/Smad compound library Contents
Description & Advantages
• A unique collection of 135 small molecule compounds for high throughput screening(HTS) and high content screening (HCS).
 
• Target includes TGF-beta/Smad, TGF-β Receptor, PKC, ROCK and RAS
 
• A useful tool for finding tumor therapeutic mechanism and  new targets.
 
• For studying human diseases, exploring the pathogenesis of diseases such as cancer, and opening noval therapeutic ways. 
 
• Structurally diverse, medicinally active, and cell permeable.
 
• Rich documentation with structure description, target information, IC50 values and customer reviews.
 
• NMR and HPLC validated to ensure high purity.

 

Product Details
Formulation 130 compounds pre-dissolved in 10mM DMSO, 2 compounds pre-dissolved in 10mM water and 3 compounds pre-dissolved in 2mM DMSO
Container 96 Well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
Stability 12 months -20°C in DMSO
24 months -80°C in DMSO
Shipping Blue ice or dry ice
Case Studies using Selleck Compound Libraries

  • Application of GPCR Compound Library in liver cancer (This article was published in Nature (IF=43) and took about 15 months):

    Nature.2019;574(7777):268-272

  • Application of Kinase Inhibitor Library in colorectal cancer (This article was published in Nature Communications (IF=11) and took about 8 months):

    Nat Commun. 2019 16;10(1):2197

  • Application of FDA-approved Drug Library in antivirus (This article was published in Cell Research (IF=17) and took about 13 months):

    Cell Res. 2019;29(9):739-753

  • Application of FDA-approved Drug Library in metabolism (This article was published in Movement Disorders (IF=8) and took about 10 months):

    Mov Disord. 2019;34(3):323-334

  • Application of Epigenetics Compound Library in acute lymphoblastic leukemia (This article was published in Blood (IF=16) and took about 16 months):

    Blood. 2019 17;134(16):1323-1336

  • Application of Inhibitor Library in tumor immunology (This article was published in Cancer Immunol Res (IF=8.6) and took about 12 months):

    Cancer Immunol Res.2017;5(9):790-803

TGF-beta/Smad compound library Composition

HTS Facility Partners