Home Neuronal Signaling GABA Receptor modulator (+)-Borneol For research use only.

(+)-Borneol

(+)-Borneol is one of enantiomers of borneol which is a valuable medical material, senior aromatic spice, and chemical material and has been used in food and also folk medicine.

(+)-Borneol Chemical Structure

(+)-Borneol Chemical Structure

CAS: 464-43-7

Purity & Quality Control

Batch: S395901 DMSO] 30 mg/mL] false] ] ] false] ] ] false Purity: 98%
98

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Signaling Pathway

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Biological Activity

Description (+)-Borneol is one of enantiomers of borneol which is a valuable medical material, senior aromatic spice, and chemical material and has been used in food and also folk medicine.
In vitro
In vitro (+)-borneol significantly inhibits the expression of iNOS and TNF-α in a dose-dependent manner in the LPS-stimulated BV-2 cells[1]. Aβ-induced cell cytotoxicity is inhibited by 100 μM of (−) and (+) borneol treatment. Treatment of borneol significantly decreases ROS generation. The expression of HO-1 and nuclear translocation of Nrf2 are increased by Aβ treatment. This nuclear translocation of Nrf2 is further increased by administration of borneol. Compared with the Aβ treated group, the (+) borneol treated group significantly increases Bcl-2 expression with decreased expression of Bax. Thus, Borneol protects SH-SY5Y cells against Aβ-induced toxicity, exerts an antioxidative effect and suppresses apoptosis[2].
Cell Research Cell lines SH-SY5Y cells
Concentrations 25, 50, 100 and 1000 μM
Incubation Time 24 h
Method

Cells are treated with various concentrations of borneol (25, 50, 100 and 1000 μM) without A β for 24 h. Cell viability is then determined by MTT assay.
In Vivo
In vivo In the rat model of permanent cerebral ischemia, (+)-borneol (1.0 mg/kg) significantly ameliorates infarct size and neurological scoresvia reducing the expression of inducible nitric oxide synthase (iNOS) and tumor necrosis factor-alpha (TNF-α) in a dose dependent manner. Notably, (+)-borneol shows long-term effects on the improvement of sensorimotor functions in the photothrombotic model of stroke, which decreases the number of foot faults in the grid-walking task and forelimb asymmetry scores in the cylinder task, at least in part through reducing loss of dendritic spines in the length, brunch number and density. (+)-Borneol obviously loosens the intercellular tight junction in the blood-brain barrier (BBB) and enhances the distribution of drugs in the brain tissue, as it could increase number and volume of pinocytotic vesicles in BBB cells and then promotes the transportation of substance by cell pinocytosis. It contributes to neuroprotection and reduces pro-inflammatory cytokine expression and promotes functional recovery from permanent stroke with a long-term effect in the acute phase of focal permanent cerebral ischemia[1].
Animal Research Animal Models Rat model of permanent cerebral ischemia (Sprague-Dawley rats)
Dosages 0.25, 0.5, 1.0, 2.0, and 4.0 mg/kg
Administration by tail intravenous injection

Chemical Information & Solubility

Molecular Weight 154.25 Formula

C10H18O
CAS No. 464-43-7 SDF --
Smiles CC1(C2CCC1(C(C2)O)C)C
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 30 mg/mL ( (194.48 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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