(+)-Borneol

For research use only.

Catalog No.S3959

(+)-Borneol Chemical Structure

CAS No. 464-43-7

(+)-Borneol is one of enantiomers of borneol which is a valuable medical material, senior aromatic spice, and chemical material and has been used in food and also folk medicine.

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Biological Activity

Description (+)-Borneol is one of enantiomers of borneol which is a valuable medical material, senior aromatic spice, and chemical material and has been used in food and also folk medicine.
In vitro

(+)-borneol significantly inhibits the expression of iNOS and TNF-α in a dose-dependent manner in the LPS-stimulated BV-2 cells[1]. Aβ-induced cell cytotoxicity is inhibited by 100 μM of (−) and (+) borneol treatment. Treatment of borneol significantly decreases ROS generation. The expression of HO-1 and nuclear translocation of Nrf2 are increased by Aβ treatment. This nuclear translocation of Nrf2 is further increased by administration of borneol. Compared with the Aβ treated group, the (+) borneol treated group significantly increases Bcl-2 expression with decreased expression of Bax. Thus, Borneol protects SH-SY5Y cells against Aβ-induced toxicity, exerts an antioxidative effect and suppresses apoptosis[2].

In vivo In the rat model of permanent cerebral ischemia, (+)-borneol (1.0 mg/kg) significantly ameliorates infarct size and neurological scoresvia reducing the expression of inducible nitric oxide synthase (iNOS) and tumor necrosis factor-alpha (TNF-α) in a dose dependent manner. Notably, (+)-borneol shows long-term effects on the improvement of sensorimotor functions in the photothrombotic model of stroke, which decreases the number of foot faults in the grid-walking task and forelimb asymmetry scores in the cylinder task, at least in part through reducing loss of dendritic spines in the length, brunch number and density. (+)-Borneol obviously loosens the intercellular tight junction in the blood-brain barrier (BBB) and enhances the distribution of drugs in the brain tissue, as it could increase number and volume of pinocytotic vesicles in BBB cells and then promotes the transportation of substance by cell pinocytosis. It contributes to neuroprotection and reduces pro-inflammatory cytokine expression and promotes functional recovery from permanent stroke with a long-term effect in the acute phase of focal permanent cerebral ischemia[1].

Protocol

Cell Research:

[2]

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  • Cell lines: SH-SY5Y cells
  • Concentrations: 25, 50, 100 and 1000 μM
  • Incubation Time: 24 h
  • Method:

    Cells are treated with various concentrations of borneol (25, 50, 100 and 1000 μM) without A β for 24 h. Cell viability is then determined by MTT assay.


    (Only for Reference)
Animal Research:

[1]

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  • Animal Models: Rat model of permanent cerebral ischemia (Sprague-Dawley rats)
  • Dosages: 0.25, 0.5, 1.0, 2.0, and 4.0 mg/kg
  • Administration: by tail intravenous injection
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 30 mg/mL (194.48 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 154.25
Formula

C10H18O

CAS No. 464-43-7
Storage powder
in solvent
Synonyms N/A
Smiles CC1(C2CCC1(C(C2)O)C)C

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID