(+)-Borneol

Catalog No.S3959

For research use only.

(+)-Borneol is one of enantiomers of borneol which is a valuable medical material, senior aromatic spice, and chemical material and has been used in food and also folk medicine.

(+)-Borneol Chemical Structure

CAS No. 464-43-7

Purity & Quality Control

Choose Selective GABA Receptor Inhibitors

Other GABA Receptor Products

Biological Activity

Description (+)-Borneol is one of enantiomers of borneol which is a valuable medical material, senior aromatic spice, and chemical material and has been used in food and also folk medicine.
In vitro

(+)-borneol significantly inhibits the expression of iNOS and TNF-α in a dose-dependent manner in the LPS-stimulated BV-2 cells[1]. Aβ-induced cell cytotoxicity is inhibited by 100 μM of (−) and (+) borneol treatment. Treatment of borneol significantly decreases ROS generation. The expression of HO-1 and nuclear translocation of Nrf2 are increased by Aβ treatment. This nuclear translocation of Nrf2 is further increased by administration of borneol. Compared with the Aβ treated group, the (+) borneol treated group significantly increases Bcl-2 expression with decreased expression of Bax. Thus, Borneol protects SH-SY5Y cells against Aβ-induced toxicity, exerts an antioxidative effect and suppresses apoptosis[2].

In vivo In the rat model of permanent cerebral ischemia, (+)-borneol (1.0 mg/kg) significantly ameliorates infarct size and neurological scoresvia reducing the expression of inducible nitric oxide synthase (iNOS) and tumor necrosis factor-alpha (TNF-α) in a dose dependent manner. Notably, (+)-borneol shows long-term effects on the improvement of sensorimotor functions in the photothrombotic model of stroke, which decreases the number of foot faults in the grid-walking task and forelimb asymmetry scores in the cylinder task, at least in part through reducing loss of dendritic spines in the length, brunch number and density. (+)-Borneol obviously loosens the intercellular tight junction in the blood-brain barrier (BBB) and enhances the distribution of drugs in the brain tissue, as it could increase number and volume of pinocytotic vesicles in BBB cells and then promotes the transportation of substance by cell pinocytosis. It contributes to neuroprotection and reduces pro-inflammatory cytokine expression and promotes functional recovery from permanent stroke with a long-term effect in the acute phase of focal permanent cerebral ischemia[1].

Protocol (from reference)

Cell Research:

[2]

  • Cell lines: SH-SY5Y cells
  • Concentrations: 25, 50, 100 and 1000 μM
  • Incubation Time: 24 h
  • Method:

    Cells are treated with various concentrations of borneol (25, 50, 100 and 1000 μM) without A β for 24 h. Cell viability is then determined by MTT assay.

  • (Only for Reference)
Animal Research:

[1]

  • Animal Models: Rat model of permanent cerebral ischemia (Sprague-Dawley rats)
  • Dosages: 0.25, 0.5, 1.0, 2.0, and 4.0 mg/kg
  • Administration: by tail intravenous injection
  • (Only for Reference)

Solubility (25°C)

In vitro

DMSO 30 mg/mL
(194.48 mM)


* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 154.25
Formula

C10H18O

CAS No. 464-43-7
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1(C2CCC1(C(C2)O)C)C

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy (+)-Borneol | (+)-Borneol supplier | purchase (+)-Borneol | (+)-Borneol cost | (+)-Borneol manufacturer | order (+)-Borneol | (+)-Borneol distributor