Succinic acid

Catalog No.S3791 Synonyms: 1,4-Butandioic Acid, 1,2-Ethanedicarboxylic acid, Amber acid, Asuccin, Butanedioic acid

For research use only.

Succinic acid (1,4-Butandioic Acid, 1,2-Ethanedicarboxylic acid, Amber acid, Asuccin, Butanedioic acid) is a crystalline organic acid which occurs in living tissue as an intermediate in glucose metabolism.

Succinic acid Chemical Structure

CAS No. 110-15-6

Purity & Quality Control

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Biological Activity

Description Succinic acid (1,4-Butandioic Acid, 1,2-Ethanedicarboxylic acid, Amber acid, Asuccin, Butanedioic acid) is a crystalline organic acid which occurs in living tissue as an intermediate in glucose metabolism.
In vivo It has been reported that succinic acid had sedative effect (4000 mg/kg) and protective action against high pressure oxygen convulsion (1180 mg/kg). Succinic acid at dose of 1180 mg/kg produces significant decrease of the locomotor activity and hyperthermia and prolonged the pentobarbital sleeping time significantly in mice. Succinic acid is found to protect rats against audiogenic seizure and inhibit the electroshock seizure in mice, but not the convulsion induced by picrotoxin, strychnine and semicarbazide. Succinic acid (100-400 mg/kg) dose-dependently inhibits pentylenetetrazol chemical and amygdale kindled seizer. Succinic acid is widely distributed in the nervous systems. Succinic acid possesses anxiolytic effects in the elevated plus-maze, food neophobia and stress-induced hyperthermia models[1].

Protocol (from reference)

Animal Research:[1]
  • Animal Models: Male Swiss mice
  • Dosages: 3.0 or 6.0 mg/kg
  • Administration: p.o./i.p.

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 118.09
Formula

C4H6O4

CAS No. 110-15-6
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C(CC(=O)O)C(=O)O

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05319262 Completed Radiation: Pink noise exposure|Radiation: Traffic noise Noise Exposure|Sleep Disturbance|Sleep Hygiene|Metabolic Disturbance|Cognitive Change Göteborg University|University of Pennsylvania|University of Manitoba April 24 2022 Not Applicable
NCT03028285 Completed Drug: arginine sodium succinate Peripheral Vascular Disease POLYSAN Scientific & Technological Pharmaceutical Company July 15 2016 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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