Home Apoptosis TNF-alpha activator - Caspase inhibitor - RIP kinase activator - Apoptosis related activator - ROS activator Citronellol

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Citronellol TNF-alpha activator

Cat.No.S5584

Citronellol (Dihydrogeraniol, (±)-β-Citronellol), a constituent of rose and geranium oils, is used in perfumes and insect repellents. This compound can cause necrotic apoptosis of NCI-H1299 cells by up-regulating TNF-α, RIP1 / RIP3 activities, and down-regulating caspase-3 / caspase-8 activities. It also results in a biphasic increase in ROS production at 1 h and at 12 h in NCI-H1299 cells.
Citronellol TNF-alpha activator Chemical Structure

Chemical Structure

Molecular Weight: 156.27

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Quality Control

Batch: S558401 Water]31 mg/mL]false]DMSO]Insoluble]false]]]false Purity: 98%
98

Chemical Information, Storage & Stability

Molecular Weight 156.27 Formula

C10H20O

 Storage (From the date of receipt) 2 years -20°C liquid
CAS No. 106-22-9 -- Storage of Stock Solutions

Synonyms Dihydrogeraniol, (±)-β-Citronellol Smiles CC(CCC=C(C)C)CCO

Solubility

In vitro
Batch:

Water : 31 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC50/Ki
TNF-α [1]
RIP1 [1]
RIP3 [1]
Caspase-3 [1]
Caspase-8 [1]
ROS [1]
References

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