Butyl isobutyl phthalate 

Catalog No.S0553 Synonyms: BIP

For research use only.

Butyl isobutyl phthalate (BIP), isolated from the rhizoid of Laminaria japonica, is a non-competitive inhibitor of α-glucosidase with IC50 of 38 μM. Butyl isobutyl phthalate displays a significant hypoglycemic effect and has the potential for diabetes treatment.

Butyl isobutyl phthalate  Chemical Structure

CAS No. 17851-53-5

Purity & Quality Control

Choose Selective Carbohydrate Metabolism Inhibitors

Biological Activity

Description Butyl isobutyl phthalate (BIP), isolated from the rhizoid of Laminaria japonica, is a non-competitive inhibitor of α-glucosidase with IC50 of 38 μM. Butyl isobutyl phthalate displays a significant hypoglycemic effect and has the potential for diabetes treatment.
Targets
α-glucosidase [1]
(Cell-free assay)
38 μM

Protocol (from reference)

Chemical Information

Molecular Weight 278.34
Formula

C16H22O4

Density 1.051
CAS No. 17851-53-5
Storage 2 years -20°C liquid
Smiles CCCCOC(=O)C1=CC=CC=C1C(=O)OCC(C)C

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04746300 Recruiting Procedure: Biopsy|Procedure: Blood sample Metastatic Prostate Cancer Radboud University|VGZ health insurance (NL)|Paul Speth Foundation (NL)|Radboud Oncology Fund (NL) February 4 2020 --
NCT04081987 Unknown status Device: non-invasive monitoring Post-cardiac Surgery|Intensive Care Unit Patients BiPS Medical|Tel-Aviv Sourasky Medical Center|Carmel Medical Center November 20 2019 --
NCT02738372 Completed Other: Diagnosis/Prognosis Chronic Shoulder Pain University of Malaga November 2016 --
NCT03206359 Completed -- Systemic Lupus Erythematosus University Hospital Grenoble January 25 2012 --

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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