Home Metabolism Carbohydrate Metabolism inhibitor Butyl isobutyl phthalate 

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Butyl isobutyl phthalate  Carbohydrate Metabolism inhibitor

Cat.No.S0553

Butyl isobutyl phthalate (BIP), isolated from the rhizoid of Laminaria japonica, is a non-competitive inhibitor of α-glucosidase with IC50 of 38 μM. Butyl isobutyl phthalate displays a significant hypoglycemic effect and has the potential for diabetes treatment.
Butyl isobutyl phthalate  Carbohydrate Metabolism inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 278.34

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Quality Control

Chemical Information, Storage & Stability

Molecular Weight 278.34 Formula

C16H22O4

 Storage (From the date of receipt) 2 years -20°C liquid
CAS No. 17851-53-5 -- Storage of Stock Solutions

Synonyms BIP Smiles CCCCOC(=O)C1=CC=CC=C1C(=O)OCC(C)C

Solubility

In vitro
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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Mechanism of Action

Targets/IC50/Ki
α-glucosidase [1]
(Cell-free assay)
38 μM
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05990361 Completed
Pregnancy-Related Pelvic Girdle Pain
Muş Alparlan University
 April 24 2023 --
NCT04746300 Recruiting
Metastatic Prostate Cancer
Radboud University Medical Center|VGZ health insurance (NL)|Paul Speth Foundation (NL)|Radboud Oncology Fund (NL)
 February 4 2020 --
NCT04081987 Unknown status
Post-cardiac Surgery|Intensive Care Unit Patients
BiPS Medical|Tel-Aviv Sourasky Medical Center|Carmel Medical Center
 November 20 2019 --
NCT02738372 Completed
Chronic Shoulder Pain
University of Malaga
 November 2016 --

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