Name: Berberine (Umbellatine)
Brand: Selleck Chemicals
SKU: S9046
Availability: InStock
Rating: 5 (15 reviews)

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Quality Control

Batch: Purity: 99.70%

99.70

Related Targets	HDAC PARP ATM/ATR DNA-PK WRN DNA/RNA Synthesis Topoisomerase PPAR Sirtuin Casein Kinase
Other Alkylating Agent Inhibitors	MNNG (1-Methyl-3-nitro-1-nitrosoguanidine)

Solubility

In vitro
Batch:

DMSO : 22.5 mg/mL (66.89 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 5 mg/mL

Water : 1 mg/mL

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.370mg/ml (1.10mM)	Taking the 1 mL working solution as an example, add 50 μL of 7.4 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

%

% Tween 80

% ddH₂O

% DMSO

+

%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	336.36	Formula	C₂₀H₁₈NO₄	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	2086-83-1	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent

Read more about storage stability stock solution CAS number

Mechanism of Action

In vitro	In 3T3-L1 adipocytes, the treatment of 12 μM or 20 μM berberine combined with 25 μM resveratrol shows more significant inhibition of lipid accumulation compared with individual compounds. The combination of this compound with resveratrol significantly increases the low-density-lipoprotein receptor expression in HepG2 cells to a level about one-fold higher in comparison to individual compounds.
In vivo	The combination of Berberine and resveratrol exerts a significant enhanced effect on lipid-lowering in hyperlipidemic mice and intracellular lipid accumulation-decreasing in adipocytes as compared to individual agent alone, which is closely associated with SIRT1 and LDLR.
References	[1] https://pubmed.ncbi.nlm.nih.gov/30563192/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-04-21)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT07541898	NOT_YET_RECRUITING	Cardiometabolic Syndrome	University of Central Lancashire	2026-07-01
NCT07440147	RECRUITING	Obesity & Overweight; Circadian Rhythm Disorders; Gut Microbiota Modulation; Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)	FH Joanneum Gesellschaft mbH	2026-01-20
NCT07465575	NOT_YET_RECRUITING	Polycystic Ovary Syndrome	Liaquat University of Medical & Health Sciences	2026-03-16
NCT05749874	ACTIVE_NOT_RECRUITING	PreDiabetes; Abdominal Obesity; Hypertension; Dyslipidemias; Atherosclerotic Cardiovascular Disease	China National Center for Cardiovascular Diseases	2023-10-31	PHASE4
NCT07129460	NOT_YET_RECRUITING	Gastric Intestinal Metaplasia	Xijing Hospital of Digestive Diseases	2025-10-01	PHASE4
NCT05105321	NOT_YET_RECRUITING	Metabolic Syndrome	Tang Yida	2021-12	PHASE4

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Berberine (Umbellatine) Alkaloid

Chemical Structure

Molecular Weight: 336.36