Salidroside
Catalog No.S2396 Synonyms: Rhodioloside
Molecular Weight(MW): 300.3
Salidroside, a phenylpropanoid glycoside isolated from Rhodiola rosea, has been reported to have a broad spectrum of pharmacological properties.
Purity & Quality Control
Biological Activity
| Description | Salidroside, a phenylpropanoid glycoside isolated from Rhodiola rosea, has been reported to have a broad spectrum of pharmacological properties. |
|---|---|
| In vitro |
Salidroside inhibits the growth of various human cancer cell lines in concentration- and time-dependent manners, and the sensitivity to salidroside is different in those cancer cell lines. Salidroside could cause G1-phase or G2-phase arrest in different cancer cell lines, meanwhile, salidroside resultes in a decrease of CDK4, cyclin D1, cyclin B1 and Cdc2, and upregulates the levels of p27(Kip1) and p21(Cip1). [1] Salidroside also alleviates cell viability loss and apoptotic cell death induced by H(2)O(2) stimulation in cultured NGF-differentiated PC12 cells by activating ERK1/2 pathway and inhibiting caspase-3 activation. [2] Salidroside activates the PI3K/Akt pathway resulting in protective effects against MPP(+)-induced apoptosis in PC12 cells, which may be used in the treatment of Parkinson's disease (PD). [3] |
| In vivo | Salidroside (20, 50 and 100 mg/kg) protects liver tissue from the oxidative stress elicited by D-galactosamine and lipopolysaccharide. [4] |
Protocol
Solubility (25°C)
| In vitro | DMSO | 60 mg/mL (199.8 mM) |
|---|---|---|
| Water | 60 mg/mL (199.8 mM) | |
| Ethanol | 4 mg/mL (13.32 mM) |
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Information
| Molecular Weight | 300.3 |
|---|---|
| Formula | C14H20O7 |
| CAS No. | 10338-51-9 |
| Storage | powder |
| in solvent | |
| Synonyms | Rhodioloside |
Bio Calculators
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