Home PI3K/Akt/mTOR mTOR activator - Mitophagy modulator - PREP inhibitor Salidroside

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Salidroside mTOR activator

Cat.No.S2396

Salidroside (Rhodioloside), a phenylpropanoid glycoside isolated from Rhodiola rosea, has been reported to have a broad spectrum of pharmacological properties. This compound is a prolyl endopeptidase inhibitor. It alleviates cachexia symptoms in mouse models of cancer cachexia via activating mTOR signalling. This chemical protects dopaminergic neurons by enhancing PINK1/Parkin-mediated mitophagy.
Salidroside mTOR activator Chemical Structure

Chemical Structure

Molecular Weight: 300.3

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Chemical Information, Storage & Stability

Molecular Weight 300.3 Formula

C14H20O7

 Storage (From the date of receipt)
CAS No. 10338-51-9 Download SDF Storage of Stock Solutions

Synonyms Rhodioloside Smiles C1=CC(=CC=C1CCOC2C(C(C(C(O2)CO)O)O)O)O

Solubility

In vitro
Batch:

DMSO : 60 mg/mL (199.8 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 60 mg/mL

Ethanol : 4 mg/mL

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
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Mechanism of Action

In vitro
Salidroside inhibits the growth of various human cancer cell lines in concentration- and time-dependent manners, and the sensitivity to this compound is different in those cancer cell lines. It could cause G1-phase or G2-phase arrest in different cancer cell lines, meanwhile, this compound resultes in a decrease of CDK4, cyclin D1, cyclin B1 and Cdc2, and upregulates the levels of p27(Kip1) and p21(Cip1). [1] This chemical also alleviates cell viability loss and apoptotic cell death induced by H(2)O(2) stimulation in cultured NGF-differentiated PC12 cells by activating ERK1/2 pathway and inhibiting caspase-3 activation. [2] It activates the PI3K/Akt pathway resulting in protective effects against MPP(+)-induced apoptosis in PC12 cells, which may be used in the treatment of Parkinson's disease (PD). [3]
In vivo
Salidroside (20, 50 and 100 mg/kg) protects liver tissue from the oxidative stress elicited by D-galactosamine and lipopolysaccharide. [4]
References

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