Chelerythrine

For research use only.

Catalog No.E0124 Synonyms: Toddaline, Broussonpapyrine

Chelerythrine Chemical Structure

CAS No. 34316-15-9

Chelerythrine (Toddaline, Broussonpapyrine) is a potent, selective antagonist of PKC with an IC50 of 0.66 μM. Chelerythrine also inhibits the BclXL-Bak BH3 peptide binding with an IC50 of 1.5 μM. Chelerythrine shows antitumor, antidiabetic and anti-inflammatory activity.

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Biological Activity

Description

Chelerythrine (Toddaline, Broussonpapyrine) is a potent, selective antagonist of PKC with an IC50 of 0.66 μM. Chelerythrine also inhibits the BclXL-Bak BH3 peptide binding with an IC50 of 1.5 μM. Chelerythrine shows antitumor, antidiabetic and anti-inflammatory activity.

Targets
BclXL-Bak BH3 [2]
()
PKC [1]
()
1.5 µM 0.66 µM

Protocol

Solubility (25°C)

In vitro DMSO 2 mg/mL (5.74 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 348.37
Formula

C21H18NO4

CAS No. 34316-15-9
Storage powder
in solvent
Synonyms Toddaline, Broussonpapyrine

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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PKC Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID