Home Metabolism P450 (e.g. CYP17) inhibitor Isosilybin

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Isosilybin P450 (e.g. CYP17) inhibitor

Cat.No.S9250

Isosilybin (Silymarin, Isosilybinin, Q-100795) is a flavanolignan found in the extract of S. marianum fruits with antioxidant and anticancer activities. Isosilybin inhibits CYP3A4 induction with an IC50 of 74 μM.
Isosilybin P450 (e.g. CYP17) inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 482.44

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Quality Control

Batch: Purity: 99.93%
99.93

Solubility

In vitro
Batch:

DMSO : 97 mg/mL (201.06 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

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Mass Concentration Volume Molecular Weight
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In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 482.44 Formula

C25H22O10

 Storage (From the date of receipt) 3 years -20°C(in the dark) powder
CAS No. 72581-71-6 -- Storage of Stock Solutions Solutions are unstable. Prepare fresh or purchase small, pre-packaged sizes. Repackage upon receipt.

Read more about storage stability CAS number SMILES

Mechanism of Action

Targets/IC50/Ki
CYP3A4
(Cell-free assay)
74 μM
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05099601 Unknown status
Melasma
Assiut University
 2022-05 Phase 4
NCT04434404 Completed
Breast Cancer
Horus University
 2018-09-10 Phase 4
NCT03216668 Unknown status
Liver Function Failure
Nhat Nhat Pharmaceutical Company
 2017-06-15 Phase 3
NCT02006498 Completed
Non-alcoholic Fatty Liver Disease
University of Malaya|Rottapharm
 2012-06 Phase 2
NCT01018615 Completed
Chronic Hepatitis C|Oxidative Stress
University of North Carolina Chapel Hill|National Center for Complementary and Integrative Health (NCCIH)|National Institutes of Health (NIH)
 2009-11 Phase 1

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