Isosilybin

Catalog No.S9250 Synonyms: Silymarin, Silybin B, Isosilybinin, Q-100795

For research use only.

Isosilybin (Silymarin, Silybin B, Isosilybinin, Q-100795) is a flavanolignan found in the extract of S. marianum fruits with antioxidant and anticancer activities. Isosilybin inhibits CYP3A4 induction with an IC50 of 74 μM.

Isosilybin Chemical Structure

CAS No. 72581-71-6

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Biological Activity

Description Isosilybin (Silymarin, Silybin B, Isosilybinin, Q-100795) is a flavanolignan found in the extract of S. marianum fruits with antioxidant and anticancer activities. Isosilybin inhibits CYP3A4 induction with an IC50 of 74 μM.
Targets
CYP3A4 [1]
(Cell-free assay)
74 μM

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 482.44
Formula

C25H22O10

CAS No. 72581-71-6
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles COC1=C(C=CC(=C1)C2C(OC3=C(O2)C=CC(=C3)C4C(C(=O)C5=C(C=C(C=C5O4)O)O)O)CO)O

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05099601 Not yet recruiting Combination Product: Silymarin|Procedure: Microneedling Melasma Assiut University May 2022 Phase 4
NCT04434404 Completed Drug: L-Carnitine 500Mg Oral Tablet Breast Cancer Horus University September 10 2018 Phase 4
NCT03216668 Unknown status Drug: TONKA|Drug: LEGALON Liver Function Failure Nhat Nhat Pharmaceutical Company June 15 2017 Phase 3
NCT02006498 Completed Drug: Sillymarin|Drug: Placebo Non-alcoholic Fatty Liver Disease University of Malaya|Rottapharm June 2012 Phase 2
NCT01018615 Completed Drug: silymarin|Dietary Supplement: green tea extract (EGCG) Chronic Hepatitis C|Oxidative Stress University of North Carolina Chapel Hill|National Center for Complementary and Integrative Health (NCCIH)|National Institutes of Health (NIH) November 2009 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-08-01)

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