Home GPCR & G Protein Adrenergic Receptor activator Isoferulic Acid

research use only

Isoferulic Acid Adrenergic Receptor activator

Cat.No.S3764

Isoferulic acid (Hesperetic acid, Hesperetate, Isoferulate), a major active ingredient of Cimicifuga heracleifolia, shows anti-inflammatory, antiviral, antioxidant, and antidiabetic properties. Isoferulic acid (3-Hydroxy-4-methoxycinnamic acid) is a cinnamic acid derivative that has antidiabetic activity. Isoferulic acid binds to and activates α1-adrenergic receptors (IC50=1.4 µM) to enhance secretion of β-endorphin (EC50=52.2 nM) and increase glucose use.
Isoferulic Acid Adrenergic Receptor activator Chemical Structure

Chemical Structure

Molecular Weight: 194.18

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: S376401 DMSO]38 mg/mL]false]]]false]]]false Purity: 99.98%
99.98

Chemical Information, Storage & Stability

Molecular Weight 194.18 Formula

C10H10O4

 Storage (From the date of receipt)
CAS No. 537-73-5 Download SDF Storage of Stock Solutions

Synonyms Hesperetic acid, Hesperetate, Isoferulate Smiles COC1=C(C=C(C=C1)C=CC(=O)O)O

Solubility

In vitro
Batch:

DMSO : 38 mg/mL ( (195.69 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

In vitro
Isoferulic acid can activate the α1A-AR to enhance glucose uptake into C2C12 cells[1]. Isoferulic acid is a potent inhibitors against intestinal maltase with an IC50 of 0.76±0.03 mM and it is also an intestinal sucrase inhibitor with IC50 of 0.45±0.01 mM. It activates α1-adrenoceptors to enhance the secretion of β-endorphin, which stimulates the opioid μ-receptors to increase glucose use and/or reduce hepatic gluconeogenesis, resulting in a reduction of the plasma glucose concentration[3].
In vivo
Isoferulic acid increases the glucose utilization in skeletal muscle and reduces the hepatic gluconeogenesis in insulin-deficient rat[1]. Isoferulic acid can inhibit hepatic gluconeogenesis and/or increase the glucose utilization in peripheral tissue to lower plasma glucose in diabetic rats lacking insulin[2].
References

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.

Signaling Pathway Map