Hydrocortisone sodium succinate

Catalog No.E0177 Synonyms: Hydrocortisone 21-hemisuccinate sodium salt

For research use only.

Hydrocortisone sodium succinate (Hydrocortisone 21-hemisuccinate sodium salt) has significant inhibitory effects on the IL-6 bioactivity with IC50 of 6.7 μM. Hydrocortisone sodium succinate can bind to glucocorticoid receptor, initiating the transcription of anti-inflammatory and immunosuppressive mediators.

Hydrocortisone sodium succinate Chemical Structure

CAS No. 125-04-2

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Biological Activity

Description

Hydrocortisone sodium succinate (Hydrocortisone 21-hemisuccinate sodium salt) has significant inhibitory effects on the IL-6 bioactivity with IC50 of 6.7 μM. Hydrocortisone sodium succinate can bind to glucocorticoid receptor, initiating the transcription of anti-inflammatory and immunosuppressive mediators.

Targets
glucocorticoid receptor [1]
()
IL-6 [1]
()
6.7 μM

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 97 mg/mL
(200.2 mM)
Water 97 mg/mL
(200.2 mM)
Ethanol 24 mg/mL
(49.53 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 484.51
Formula

C25H33O8.Na

CAS No. 125-04-2
Storage 3 years -20°C powder
2 years -80°C in solvent

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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