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PROTAC

Catalog No. Product Name Information
S0070 Gefitinib-based PROTAC 3 Gefitinib-based PROTAC 3 which conjugates an EGFR binding element to a VHL ligand via a linker induces degradation of EGFR and mutants with DC50 of 11.7 nM and 22.3 nM in HCC827(Exon 19 del) and H3255 (L858R) cells, respectively.
S0072 MS4078 MS4078 is an inhibitor and PROTAC (degrader) of ALK. MS4078 reduces the NPM-ALK protein levels in SU-DHL-1 cells and the EML4-ALK protein levels in NCI-H2228 cells with DC50 of 11 nM and 59 nM, respectively. MS4078 induces ALK protein degradation via cereblon and proteasome dependent mechanism and potently inhibits proliferation of SU-DHL-1 cells with IC50 of 33 nM.
S0137 dBET57 dBET57 is a novel, potent and selective degrader of BRD4BD1 based on the PROTAC technology with DC50/5h of 500 nM. dBET57 is inactive on BRD4BD2.
S8296 dBET1 dBET1 is a CRBN-based BET degrader with an IC50 of 20 nM, showing highly selectivity. Out of 7,429 proteins, only the expression of the oncoproteins MYC and PIM1, as well as BRD2, BRD3 and BRD4 are significantly downregulated by dBET1 treatment.
S8297 ARV-825 ARV-825 is a BRD4 Inhibitor that recruits BRD4 to the E3 ubiquitin ligase cereblon, leading to fast, efficient, and prolonged degradation of BRD4 and sustained down-regulation of MYC.
S8532 ARV-771 ARV-771 is a potent pan-(bromodomain and extra-terminal)BET degrader, a novel BET-PROTAC(proteolysis-targeting chimera) with Kd of 34 nM, 4.7 nM, 8.3 nM, 7.6 nM, 9.6 nM, and 7.6 nM for BRD2(1), BRD2(2), BRD3(1), BRD3(2), BRD4(1), and BRD4(2), respectively.
S8762 dBET6 dBET6 is a highly cell-permeable PROTAC degrader of BET bromodomains with an IC50 of 14 nM for BRD4 binding. dBET6 also induces c-MYC downregulation and apoptosis.
S8785 A1874 A1874 is a much improved nutlin-based, BRD4-degrading PROTAC and is able to degrade its target protein by 98% with nanomolar potency.
S8888 GMB-475 GMB-475 is a proteolysis-targeting chimera (PROTAC) that allosterically targets BCR-ABL1 protein and recruit the E3 ligase Von Hippel-Lindau (VHL), resulting in ubiquitination and subsequent degradation of the oncogenic fusion protein.
S0567 Amino-PEG4-alcohol Amino-PEG4-alcohol is a PEG-based PROTAC linker used in the synthesis of PROTACs. Amino-PEG4-alcohol is a non-cleavable 4-unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
S0576 NH2-PEG2-C2-Boc NH2-PEG2-C2-Boc is a PEG-based PROTAC linker that can be applied into the synthesis of PROTACs. NH2-PEG2-C2-Boc is a non-cleavable 2-unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
S0590 Propargyl-PEG5-amine Propargyl-PEG5-amine is a non-cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs) and a PEG-based PROTAC linker applied into the synthesis of PROTACs.
S0593 Amino-PEG4-CH2COOH Amino-PEG4-CH2COOH is a PEG-based PROTAC linker that can be applied into the synthesis of PROTACs. Amino-PEG4-CH2COOH is also a non-cleavable 4-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0603 m-PEG12-amine m-PEG12-amine is a PEG-based PROTAC linker that can be applied into the synthesis of PROTACs. m-PEG12-amine is also a non-cleavable 12-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0605 Azido-PEG4-CH2-Boc Azido-PEG4-CH2-Boc is a cleavable 4-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs). Azido-PEG4-CH2-Boc is also a PEG- and Alkyl/ether-based PROTAC linker that can be applied into the synthesis of PROTACs.
S0616 Azido-PEG2-C2-amine Azido-PEG2-C2-amine (N3-PEG2-CH2CH2NH2) is a PEG-based PROTAC linker that can be applied into the synthesis of PROTACs. Azido-PEG2-C2-amine is a non-cleavable 2-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0640 NH2-PEG5-OH NH2-PEG5-OH is a PEG-based PROTAC linker that can be applied into the synthesis of PROTACs. NH2-PEG5-OH is also a non-cleavable 5-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0642 Azido-PEG6-amine Azido-PEG6-amine is a PEG-based PROTAC linker that can be applied into the synthesis of PROTACs. Azido-PEG6-amine is also a non-cleavable 6-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0664 m-PEG10-alcohol m-PEG10-alcohol (Decaethylene glycol monomethyl ether) is a non-cleavable 10-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs). m-PEG10-alcohol is also a PEG-based PROTAC linker that can be applied into the synthesis of PROTACs.
S0668 Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine is a cleavable PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs). Amino-Tri-(t-butoxycarbonylethoxymethyl)-methane is also a PEG-based PROTAC linker that can be applied into the synthesis of PROTACs.
S0670 N3-PEG3-CH2CH2-Boc N3-PEG3-CH2CH2-Boc is a cleavable 3-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs). N3-PEG3-CH2CH2-Boc is also a PEG- and Alkyl/ether-based PROTAC linker that can be applied into the synthesis of PROTACs.
S0687 NH2-PEG6-Boc NH2-PEG6-Boc is a PEG-based PROTAC linker that can be applied into the synthesis of PROTACs. NH2-PEG6-Boc is also a non-cleavable 6-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0689 Bis-PEG8-acid Bis-PEG8-acid is a PEG-based PROTAC linker can be applied into the synthesis of PROTACs. Bis-PEG8-acid is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
S0696 Propargyl-PEG2-NHBoc Propargyl-PEG2-NHBoc is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-NHBoc is a PEG-based PROTAC linker can be applied into the synthesis of PROTACs.
S0698 Boc-NH-PEG4-CH2CH2COOH Boc-NH-PEG4-CH2CH2COOH is a PEG-based PROTAC linker can be applied into the synthesis of PROTAC. Boc-NH-PEG4-CH2CH2COOH is a cleavable ADC linker used as a linker for antibody-drug conjugates (ADC).
S1127 3-Maleimidopropionic acid 3-Maleimidopropionic acid is an alkyl chain-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1131 Amino-PEG3-C2-Amine Amino-PEG3-C2-Amine is a PEG-based PROTAC linker can be that is applicable to the synthesis of PROTACs.
S1246 NH2-PEG3-C2-NH-Boc NH2-PEG3-C2-NH-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1279 Boc-NH-PEG2-C2-NH2 Boc-NH-PEG2-C2-NH2 is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1295 NH2-C4-NH-Boc NH2-C4-NH-Boc is a PROTAC linker that refers to the Alkyl/ether composition. NH2-C4-NH-Boc can be applicable to the synthesis of a series of PROTACs.
S1298 Boc-NH-PEG3 Boc-NH-PEG3 is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1301 PEG5-Tos PEG5-Tos is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1306 Amino-PEG4-C2-amine Amino-PEG4-C2-amine is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1307 NH2-PEG1-CH2CH2-Boc NH2-PEG1-CH2CH2-Boc is a PEG- and Alkyl/ether-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1309 3,6-Dioxaoctanedioic acid 36-Dioxaoctanedioic acid is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1320 NH2-C2-NH-Boc NH2-C2-NH-Boc is a alkyl chain-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1347 Bis-NH2-PEG2 Bis-NH2-PEG2 is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1350 Bis-PEG3-acid Bis-PEG3-acid is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1355 Boc-N-Amido-PEG2-C2-azide Boc-N-Amido-PEG2-C2-azide is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1365 Biotin-PEG6-alcohol Biotin-PEG6-alcohol is a biotin-labeled and PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1388 Azido-PEG2-CH2COOH Azido-PEG2-CH2COOH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1411 Propargyl-PEG4-alcohol Propargyl-PEG4-alcohol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1414 m-PEG6-CH2CH2COOH m-PEG6-CH2CH2COOH is a PEG-based based PROTAC linker that is applicable to the synthesis of PROTACs.
S1417 Thiol-PEG8-acid Thiol-PEG8-acid is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1418 Azido-PEG3-alcohol Azido-PEG3-alcohol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1429 BnO-PEG4-OH BnO-PEG4-OH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1447 Azido-PEG8-amine Azido-PEG8-amine is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1449 Br-PEG4-OH Br-PEG4-OH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1495 Hydroxy-PEG5-Boc Hydroxy-PEG5-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1520 m-PEG5-acid m-PEG5-acid is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1551 Azido-PEG1-CH2CO2H Azido-PEG1-CH2CO2H is a PROTAC linker, which refers to the alkyl/ether composition. Azido-PEG1-CH2CO2H is applicable to the synthesis of PROTAC BRD4 Degrader-1.
S1552 Br-PEG3-C2-Boc Br-PEG3-C2-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1559 Tos-PEG3 Tos-PEG3 is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs. Tos-PEG3 can be used in the synthesis of 3'-aminooxy oligonucleotides solid supports.
S1562 Mal-amido-PEG2-C2-acid Mal-amido-PEG2-C2-acid is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1563 m-PEG6-O-CH2COOH m-PEG6-O-CH2COOH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1564 Diethylene glycol bis(p-toluenesulfonate) Diethylene glycol bis(p-toluenesulfonate) (Diethylene glycol di(p-toluenesulfonate), Bis-Tos-PEG2) is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1566 Amino-PEG5-amine Amino-PEG5-amine is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1581 Propargyl-PEG2-OH Propargyl-PEG2-OH is a PEG-based PROTAC linker that is applicable to the synthesis of Thalidomide-O-PEG2-propargyl.
S1596 Biotin-PEG4-acid Biotin-PEG4-acid is a PEG-based PROTAC linker that is applicable to the synthesis of PROTAC.
S1597 3-(2-Pyridyldithio)propanoic Acid 3-(2-Pyridyldithio)propanoic Acid is an alkyl chain-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1600 Dodecaethylene glycol Dodecaethylene glycol (HO-PEG12-OH) is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1602 m-PEG8-thiol m-PEG8-thiol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1632 Boc-N-Amido-PEG3-azide Boc-N-Amido-PEG3-azide is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1650 NH2-PEG3 NH2-PEG3 is a PROTAC linker that belongs to a polyethylene glycol (PEG) linker. NH2-PEG3 is applicable to the synthesis of the PROTAC (β-NF-JQ1).
S1656 m-PEG3-Tos m-PEG3-Tos is a PEG-based PROTAC linker that is applicable to the synthesis of Silymarin.
S1659 Br-C10-methyl ester Br-C10-methyl ester is a PROTAC linker that refers to the alkyl/ether composition. Br-C10-methyl ester is applicable to the synthesis of a series of PROTACs.
S1660 2-(Benzyloxy)ethanol 2-(Benzyloxy)ethanol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1661New 5-Ethynyl-2'-deoxyuridine 5-Ethynyl-2'-deoxyuridine (EdU, 5-EdU, 2'-Deoxy-5-ethynyluridine), a thymidine analogue, which can be incorporated into cellular DNA and the subsequent reaction of EdU with a fluorescent azide in a copper-catalyzed [3+2] cycloaddition ("Click" reaction) are developed as a method for detection of DNA synthesis. 5-Ethynyl-2'-deoxyuridine is an alkyl chain-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1663 Nonaethylene glycol monomethyl ether Nonaethylene glycol monomethyl ether is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1664New Di(N-succinimidyl) adipate Di(N-succinimidyl) adipate (DSAP) is an alkyl chain-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1670 Azido-PEG4-Boc Azido-PEG4-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1674 Amino-PEG4-Boc Amino-PEG4-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1682 BnO-PEG5-OH BnO-PEG5-OH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1684 Br-PEG3-OH Br-PEG3-OH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1686 Bromo-PEG2-alcohol Bromo-PEG2-alcohol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1687 Bromo-PEG4-bromide Bromo-PEG4-bromide is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1694 Boc-GABA-OH Boc-GABA-OH is a PROTAC linker that can be applied to synthesis UNC6852, an EED-targeted PROTAC.
S1695 4-Maleimidobutyric acid 4-Maleimidobutyric acid is an alkyl chain-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1697New Heptaethylene glycol Heptaethylene glycol (HO-PEG7-OH) is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1699 Decaethylene glycol Decaethylene glycol (HO-PEG10-OH) is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1710 Triethylene glycol monobenzyl ether Triethylene glycol monobenzyl ether is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1720 m-PEG5-NH2 m-PEG5-NH2 is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1722 PEG3-O-CH2COOH PEG3-O-CH2COOH is a PEG-based PROTAC linker that is applicable to the synthesis of SNIPERs.
S1728 Hydroxy-PEG2-CH2COOH Hydroxy-PEG2-CH2COOH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1745 Hydroxy-PEG3-CH2-Boc Hydroxy-PEG3-CH2-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1746 Azido-PEG5-amine Azido-PEG5-amine is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1752 Octaethylene glycol Octaethylene glycol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1755 Pentaethylene glycol Pentaethylene glycol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1757 Amino-PEG9-amine Amino-PEG9-amine is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1758 Hexane-1,6-diyldiphosphonic acid Hexane-1,6-diyldiphosphonic acid is an alkyl chain-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1765 Butane-1,4-diyldiphosphonic acid Butane-1,4-diyldiphosphonic acid is an alkyl chain-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1766 m-PEG7-alcohol m-PEG7-alcohol (O-Methyl-heptaethylene glycol) is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1769 Bis-Tos-PEG6 Bis-Tos-PEG6 is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1772New Bis-NH2-C1-PEG3 Bis-NH2-C1-PEG3 (PROTAC Linker 24) is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1779 Pentaethylene glycol di-p-toluenesulfonate Pentaethylene glycol di-p-toluenesulfonate (Penta(ethylene glycol) bis(p-toluenesulfonate), Bis-Tos-PEG5) is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1780 Propynol Ethoxylate Propynol Ethoxylate is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1781 Bis-Tos-PEG4 Bis-Tos-PEG4 is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1783 1,2-Bis(2-iodoethoxy)ethane 1,2-Bis(2-iodoethoxy)ethane is a PEG-based PROTAC linker. 1,2-Bis(2-iodoethoxy)ethane is applicable to the synthesis of MT802 and SJF620 which are potent PROTAC BTK degraders with DC50 of 1 nM and 7.9 nM, respectively.
S1785 Nonaethylene glycol Nonaethylene glycol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1795 Amino-PEG7-amine Amino-PEG7-amine is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1796 Monoethyl pimelate Monoethyl pimelate is a PROTAC linker that refers to the alkyl/ether composition. Monoethyl pimelate is applicable to the synthesis of (S,R,S)-AHPC-Me-C7 ester, a specific BCL-XL PROTAC degrader.
S1797 Hydroxy-PEG6-CH2-Boc Hydroxy-PEG6-CH2-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1798 Hydroxy-PEG1-CH2-Boc Hydroxy-PEG1-CH2-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1800 2,2-Oxybis(ethylamine) 22-Oxybis(ethylamine) is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1803New 5-Boc-amino-pentanoic acid 5-Boc-amino-pentanoic acid (Boc-5-aminovaleric acid, Boc-NH-C4-acid, Boc-5-Ava-OH) is a PROTAC linker that belongs to a Alkyl/ether linker. Boc-NH-C4-acid is applicable to the synthesis of PROTAC1, and specifically degrades EED, EZH2, and SUZ12 in the PRC2 Complex.
S1804 Hexaethylene glycol Hexaethylene glycol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1809 Octaethylene glycol monomethyl ether Octaethylene glycol monomethyl ether is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1810 Pentaethylene glycol monomethyl ether Pentaethylene glycol monomethyl ether is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1812 Hexaethylene glycol monomethyl ether Hexaethylene glycol monomethyl ether is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1814New tert-Butyl 11-aminoundecanoate tert-Butyl 11-aminoundecanoate (compound 6b) is a PROTAC linker that refers to the PEG composition. tert-Butyl 11-aminoundecanoate is applicable to the synthesis of a series of PROTACs.
S1815 m-PEG2-azide m-PEG2-azide is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1817 Bromo-PEG3-CH2-Boc Bromo-PEG3-CH2-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1818 Propargyl-PEG3-alcohol Propargyl-PEG3-alcohol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1821 Boc-NH-PEG7-azide Boc-NH-PEG7-azide is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1824 Boc-NH-PEG7-acid Boc-NH-PEG7-acid is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1838 Diethylene Glycol Monobenzyl Ether Diethylene Glycol Monobenzyl Ether is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1841 Tos-PEG5-CH2COOtBu Tos-PEG5-CH2COOtBu is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1842 NH2-PEG3-C1-Boc NH2-PEG3-C1-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1844 Fmoc-N-PEG7-acid Fmoc-N-amido-PEG7-acid is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1846New Hydroxy-PEG4-O-Boc Hydroxy-PEG4-O-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
S1850 Bromo-PEG2-CH2-Boc Bromo-PEG2-CH2-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1852 Br-PEG4-CH2-Boc Br-PEG4-CH2-Boc is a PEG- and Alkyl/ether-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1860 HO-PEG13-OH HO-PEG13-OH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1861 Azido-PEG3-C-Boc Azido-PEG3-C-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1862 Tos-PEG4-CH2-Boc Tos-PEG4-CH2-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1864 Fmoc-NH-PEG1-C2-acid Fmoc-NH-PEG1-C2-acid is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1867 Tos-PEG1-CH2-Boc Tos-PEG1-CH2-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1868 Bromo-PEG1-CH2-Boc Bromo-PEG1-CH2-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1870 N-Boc-4-pentyne-1-amine N-Boc-4-pentyne-1-amine is a PROTAC linker that refers to the alkyl chain composition. N-Boc-4-pentyne-1-amine is applicable to the synthesis of the PROTAC MG-277.
S1871 Hydroxy-PEG2-CH2-Boc Hydroxy-PEG2-CH2-Boc is a PEG/Alkyl/ether-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1872 Amino-PEG1-C2-acid Amino-PEG1-C2-acid is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1877 Azido-PEG5-Boc Azido-PEG5-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1879 Boc-NH-PEG1-CH2COOH Boc-NH-PEG1-CH2COOH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1882 NH2-PEG7 NH2-PEG7 is a PROTAC linker that refers to the PEG composition. NH2-PEG7 is applicable to the synthesis of the PROTAC PARP1 degrader iRucaparib-AP6.
S1886 Boc-NH-PEG12-CH2CH2COOH Boc-NH-PEG12-CH2CH2COOH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1887 Propargyl-PEG4-acid Propargyl-PEG4-acid is a PEG-based PROTAC linker that is applicable to the synthesis of BTK-IAP PROTACs Ibrutinib-based PROTAC 2 and an analogue PROTAC 3. PROTAC 3 causes BTK degradation with DC50 of 200 nM in THP-1 cells.
S1892 N-Boc-PEG5-alcohol N-Boc-PEG5-alcohol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1901 Fmoc-amino-PEG3-CH2COOH Fmoc-amino-PEG3-CH2COOH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1906 Bromo-PEG1-C2-Boc Bromo-PEG1-C2-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1912New 3,6,9-Trioxaundecanedioic Acid 3,6,9-Trioxaundecanedioic acid is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1918 Bromo-PEG2-C2-Boc Bromo-PEG2-C2-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1919 Propargyl-PEG3-Boc Propargyl-PEG3-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1922 Propargyl-PEG4-Boc Propargyl-PEG4-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1925 Amino-PEG3-CH2COOH Amino-PEG3-CH2COOH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1926 m-PEG5-CH2CH2COOH m-PEG5-CH2CH2COOH is a PEG-based based PROTAC linker that is applicable to the synthesis of PROTACs.
S1927 N-Boc-PEG8-alcohol N-Boc-PEG8-alcohol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1930 Mal-NH-Boc Mal-NH-Boc is an alkyl/ether-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1931 Amino-PEG3-C2-Azido Amino-PEG3-C2-Azido is a PEG-based PROTAC linker that is applicable to the synthesis of the PARP1 degrader iRucaparib-TP3.
S1932 m-PEG16-alcohol m-PEG16-alcohol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1935 Fmoc-NH-PEG8-NHS ester Fmoc-NH-PEG8-NHS ester is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1936 Boc-NH-PEG8-CH2CH2COOH Boc-NH-PEG8-CH2CH2COOH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1938 Azido-PEG2-C2-acid Azido-PEG2-C2-acid is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1942 Boc-NH-PEG6-azide Boc-NH-PEG6-azide is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1943 Amino-PEG2-NH-Boc Amino-PEG2-NH-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1944 m-PEG6-Br m-PEG6-Br is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1945 N-Boc-serinol N-Boc-serinol is an alkyl/ether-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1946 Propargyl-PEG1-NH2 Propargyl-PEG1-NH2 is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1947 Biotin-PFP ester Biotin-PFP ester is an alkyl/ether-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1948 HO-PEG14-OH HO-PEG14-OH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1951 Tetraethylene glycol Tetraethylene glycol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1953 m-PEG3-OH m-PEG3-alcohol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1954 Triethylene glycol Triethylene glycol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1955 Boc-NH-PEG2-CH2COOH Boc-NH-PEG2-CH2COOH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1961 Boc-NH-PEG4 Boc-NH-PEG4 is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1963 Boc-11-aminoundecanoic acid Boc-11-aminoundecanoic acid is an Alkyl/ether-based PROTAC linker that is applicable to the synthesis of MS432.
S1966 Propargyl-PEG12-OH Propargyl-PEG12-OH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S1967 Propargyl-PEG4-amine Propargyl-PEG4-amine is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
S0095 VL285 VL285 is a potent VHL ligand that degrades HaloTag7 fusion proteins. Cotreatment with excess VL285, the core VHL ligand from which HaloPROTAC3 is derived, is able to significantly reduce HaloPROTAC3 mediated activity to 50% degradation.
S0097 (S,R,S)-AHPC (MDK7526) (S,R,S)-AHPC (MDK7526, VH032-NH2, VHL ligand 1) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC is potential useful for the targeted degradation of the androgen receptor. (S,R,S)-AHPC can be connected to the ligand for protein such as BCR-ABL1 by a linker to form PROTACs such as GMB-475. GMB-475 induces the degradation of BCR-ABL1 with IC50 of 1.11 μM in Ba/F3 cells.
S0322New BC-1215 BC-1215 is an inhibitor of F-box protein 3 (Fbxo3, a ubiquitin E3 ligase component) with IC50 of 0.9 μg/mL and LC50 of 87 μg/ml for IL-1β release. BC-1215 inhibits the Fbxo3-TRAF activation pathway by destabilizing TRAF1-6.
S1000 Thalidomide fluoride Thalidomide fluoride (Cereblon ligand 4, E3 ligase Ligand 4) is the Thalidomide-based Cereblon ligand that is applicable to the recruitment of CRBN protein. Thalidomide fluoride can be connected to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1.
S1015 Thalidomide-OH Thalidomide-OH (Cereblon ligand 2, E3 ligase Ligand 2) is the Thalidomide-based Cereblon ligand that is applicable to the recruitment of CRBN protein. Thalidomide-OH can be connected to the ligand for protein by a linker to form PROTACs.
S1016 Lenalidomide-Br Lenalidomide-Br is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is that is applicable to the recruitment of CRBN protein. Lenalidomide-Br can be connected to the ligand for protein by a linker to form PROTACs.
S1029 Lenalidomide (CC-5013) Lenalidomide (CC-5013) is a TNF-α secretion inhibitor with IC50 of 13 nM in PBMCs. Lenalidomide (CC-5013) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide promotes cleaved caspase-3 expression and inhibit VEGF expression and induces apoptosis.
S1062 (S,R,S)-AHPC hydrochloride (S,R,S)-AHPC hydrochloride (VH032-NH2, VHL ligand 1) is the VH032-based VHL ligand that is applicable to the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC hydrochloride can be connected to the ligand for protein by a linker to form PROTACs.
S1193 Thalidomide (K17) Thalidomide (K17) was introduced as a sedative drug, immunomodulatory agent and also is investigated for treating symptoms of many cancers. Thalidomide inhibits an E3 ubiquitin ligase, which is a CRBN-DDB1-Cul4A complex.
S1567 Pomalidomide (CC-4047) Pomalidomide (CC-4047) inhibits LPS-induced TNF-α release with IC50 of 13 nM in PBMCs. Pomalidomide can be utilized in PROTAC as a ligand for targeting E3 ligase and inhibiting the E3 ligase protein cereblon (CRBN). Pomalidomide promotes apoptosis and cell cycle arrest.
S6794 Thalidomide-O-COOH (Cereblon ligand 3) Thalidomide-O-COOH (Cereblon ligand 3, E3 ligase Ligand 3), a Thalidomide-based Cereblon (CRBN) ligand, is used in the recruitment of CRBN protein. Thalidomide-O-COOH (Cereblon ligand 3) can be connected to the ligand for protein by a linker to form PROTACs (Proteolysis Targeting Chimera).
S8760 Iberdomide (CC220) Iberdomide (CC-220) is a novel oral immunomodulatory compound that targets cereblon, part of the CRL4CRBN E3 ubiquitin ligase complex, with an IC50 of 60 nM in a competitive TR-FRET assay. Iberdomide (CC-220) induces apoptosis with antitumor and immunostimulatory activities.
S1526 Quizartinib (AC220) Quizartinib (AC220) is a second-generation FLT3 inhibitor for Flt3(ITD/WT) with IC50 of 1.1 nM/4.2 nM in MV4-11 and RS4;11 cells, respectively, 10-fold more selective for Flt3 than KIT, PDGFRα, PDGFRβ, RET, and CSF-1R. Quizartinib (AC220) induces apoptosis of tumor cells. Phase 3.
S2680 Ibrutinib (PCI-32765) Ibrutinib (PCI-32765) is a potent and highly selective Brutons tyrosine kinase (Btk) inhibitor with IC50 of 0.5 nM in cell-free assays, modestly potent to Bmx, CSK, FGR, BRK, HCK, less potent to EGFR, Yes, ErbB2, JAK3, etc. Ibrutinib is applicable as a Btk ligand in the synthesis of a series of PROTACs including P13I.
S6545 BI-4464 BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC50 of 17 nM.
S7110 (+)-JQ1 (+)-JQ1 is a BET bromodomain inhibitor, with IC50 of 77 nM/33 nM for BRD4(1/2) in cell-free assays, binding to all bromodomains of the BET family, but not to bromodomains outside the BET family. (+)-JQ1 suppresses cell proliferation via inducing autophagy. (+)-JQ1 inhibits the expression of Nuclear receptor binding SET domain protein 3 (NSD3) target genes.