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Pyroptosis Compound Library

Catalog No.L7400

A unique collection of 756 pyroptosis related compounds used for high throughput screening(HTS) and high content screening(HCS).

96 well plates

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Cited by 310 Publications

Pyroptosis Compound Library Contents

Description & Advantages

•Pyroptosis is a form of necrotic and inflammatory programmed cell death mediated by the activation of caspase-1.Pyroptosis is widely involved in the occurrence and development of infectious diseases, nervous system related diseases and atherosclerotic diseases.Recent studies have shown that pyroptosis can enhance anti-tumor immunity;
 
•A unique collection of 756 pyroptosis related compounds used for high throughput screening(HTS) and high content screening(HCS);
 
•Some compounds have been approved by the FDA;
 
•Structurally diverse,medicinally active,and cell permeable;
 
•Rich documentation with structure and bioactivity information;
 
•NMR and HPLC validated to ensure high purity.

Product Details

Formulation 708 compounds pre-dissolved in 10mM DMSO, 25 compounds pre-dissolved in 10mM water, 20 compounds pre-dissolved in 2mM DMSO and 3 compounds pre-dissolved in 2mM water
Container 96 Deep Well Plate Sealed With Aluminum Foil
Stability 12 months -20°C in DMSO
24 months -80°C in DMSO
Shipping Blue ice or dry ice

Case Studies using Selleck Compound Libraries

  • Application of GPCR Compound Library in liver cancer (This article was published in Nature (IF=43) and took about 15 months):

    Nature.2019;574(7777):268-272

  • Application of Kinase Inhibitor Library in colorectal cancer (This article was published in Nature Communications (IF=11) and took about 8 months):

    Nat Commun. 2019 16;10(1):2197

  • Application of FDA-approved Drug Library in antivirus (This article was published in Cell Research (IF=17) and took about 13 months):

    Cell Res. 2019;29(9):739-753

  • Application of FDA-approved Drug Library in metabolism (This article was published in Movement Disorders (IF=8) and took about 10 months):

    Mov Disord. 2019;34(3):323-334

  • Application of Epigenetics Compound Library in acute lymphoblastic leukemia (This article was published in Blood (IF=16) and took about 16 months):

    Blood. 2019 17;134(16):1323-1336

  • Application of Inhibitor Library in tumor immunology (This article was published in Cancer Immunol Res (IF=8.6) and took about 12 months):

    Cancer Immunol Res.2017;5(9):790-803

Pyroptosis Compound Library Composition

HTS Facility Partners