Tetracycline

Catalog No.S4490 Synonyms: TC

For research use only.

Tetracycline (TC) is a broad-spectrum antibiotic that exhibits activity against a wide range of microorganisms including gram-positive and gram-negative bacteria, chlamydiae, mycoplasmas, rickettsiae, and protozoan parasites.

Tetracycline Chemical Structure

CAS No. 60-54-8

Purity & Quality Control

Choose Selective Bacterial Inhibitors

Biological Activity

Description Tetracycline (TC) is a broad-spectrum antibiotic that exhibits activity against a wide range of microorganisms including gram-positive and gram-negative bacteria, chlamydiae, mycoplasmas, rickettsiae, and protozoan parasites.

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 89 mg/mL
(200.25 mM)
Water Insoluble
Ethanol ''''22 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 444.43
Formula

C22H24N2O8

CAS No. 60-54-8
Storage 3 years -20°C powder
2 years -80°C in solvent

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04555564 Not yet recruiting Procedure: Technicium 99 MAA infusion Hemoptysis|Malignant Neoplasm|Lung Cancer Johns Hopkins University|Boston Scientific Corporation August 1 2022 Not Applicable
NCT05154747 Not yet recruiting Drug: Cabotegravir Rilpivirine Drug Combination|Drug: TLD Hiv|HIV Infections|HIV-1-infection|Paediatric Human Immunodeficiency Virus Infection University College London|European and Developing Countries Clinical Trials Partnership (EDCTP)|Janssen-Cilag Ltd.|ViiV Healthcare|Department of Clinical Pharmacy University Medical Centre St Radboud The Netherlands.|London School of Hygiene and Tropical Medicine|MRC/UVRI and LSHTM Uganda Research Unit|Africa Health Research Institute|PENTA Foundation|University of York August 2022 Phase 3
NCT05188430 Not yet recruiting Device: Medical Device (Kaptufat®)|Other: Placebo Hypercholesterolemia|Overweight and Obesity University of Bologna March 1 2022 Not Applicable

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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