Name: Piperine
Brand: Selleck Chemicals
SKU: S2344
Availability: InStock
Rating: 5 (2 reviews)

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Quality Control

Batch: Purity: 99.92%

99.92

Related Targets	Dehydrogenase HSP Transferase PDE phosphatase PPAR Vitamin Carbohydrate Metabolism Mitochondrial Metabolism Casein Kinase
Other P450 (e.g. CYP17) Inhibitors	Apigenin Baicalein Naringenin Diosmetin Alizarin Sodium Danshensu Naringin Benzbromarone Orteronel Isosilybin

Solubility

In vitro
Batch:

DMSO : 57 mg/mL (199.76 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 57 mg/mL

Water : Insoluble

DMSO : 240 mg/mL (841.1 mM) Warmed with 60°C water bath; Ultrasonicated;
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 57 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	6.000mg/ml (21.03mM)	Taking the 1 mL working solution as an example, add 50 μL of 120 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

%

% Tween 80

% ddH₂O

% DMSO

+

%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	285.34	Formula	C₁₇H₁₉NO₃	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	94-62-2	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	1-Piperoylpiperidine			SMILES	C1CCN(CC1)C(=O)C=CC=CC2=CC3=C(C=C2)OCO3

Read more about storage stability stock solution CAS number SMILES

Mechanism of Action

Targets/IC₅₀/Ki	CYP3A4
In vitro	Piperine (1-Piperoylpiperidine) is the alkaloid responsible for the pungency of black pepper and long pepper, along with chavicine (an isomer of piperine). It has also been used in some forms of traditional medicine and as an insecticide. This compound has been found to inhibit human CYP3A4 and P-glycoprotein, enzymes important for the metabolism and transport of xenobiotics and metabolites. It is found to be cytotoxic towards DLA and EAC cells at a concentration of 250 μ g/ml. This chemical (1.14 mg/dose/animal) could inhibit the solid tumor development in mice induced with DLA cells and increase the life span of mice bearing Ehrlich ascites carcinoma tumor.
In vivo	LD50: Mice 15.1mg/kg (i.v.), 43mg/kg (i.p.), 200mg/kg (s.c.), 330mg/kg (i.g.); Rats 33.5mg/kg (i.p.), 514mg/kg (i.g.)
References	[1] https://pubmed.ncbi.nlm.nih.gov/12130727/ [2] https://pubmed.ncbi.nlm.nih.gov/15013199/ [3] https://pubmed.ncbi.nlm.nih.gov/6857729/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-08-11)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT07753018	NOT_YET_RECRUITING	Fibromyalgia (FM)	Ain Shams University	2026-08-01	PHASE2
NCT06063486	RECRUITING	Clonal Cytopenia of Undetermined Significance; Essential Thrombocythemia; Myelodysplastic Syndrome; Myelofibrosis; Polycythemia Vera	University of Southern California	2024-03-01	PHASE2
NCT07699575	NOT_YET_RECRUITING	Joint Pains	Centre Hospitalier Universitaire de la Réunion	2026-09-14
NCT05958173	UNKNOWN	Oropharyngeal Dysphagia; Swallowing Disorder	Hospital de Mataró	2023-09-01
NCT06080841	RECRUITING	Locally Advanced Cervical Cancer	National Institute of Cancerología	2023-04-19
NCT07149961	COMPLETED	ST Elevation Myocardial Infarction (STEMI); Malondialdehyde; Hs-CRP; Curcumin; Curcuma Xanthorrhiza; High-sensitivity C-reactive Protein	Universitas Diponegoro	2025-02-05

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Piperine P450 (e.g. CYP17) inhibitor

Chemical Structure

Molecular Weight: 285.34