Piperine

Catalog No.S2344 Synonyms: 1-Piperoylpiperidine

Piperine Chemical Structure

Molecular Weight(MW): 285.34

Piperine (1-Piperoylpiperidine) is the alkaloid responsible for the pungency of black pepper and long pepper, which has also been used in some forms of traditional medicine and as an insecticide.

Size Price Stock Quantity  
In DMSO USD 350 In stock
USD 40 In stock
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Cited by 1 Publication

1 Customer Review

  • Piperine attenuates inflammation in the substantia nigra (SN) of the MPTP-treated brains. (A) Iba-1-immunostaining was performed on brain sections for microglia. Piperine alleviated microglia activating caused by MPTP. (B) Brain tissue was stained with the anti-interleukin-1β (IL-1β) antibody in the SN. MPTP notably increased the expression of IL-1β in the SN of the mice and the increase was partly blocked by piperine. (C) Western blot analysis of IL-1β expression in the SN. (D) Densitometric analysis of western blot analyses of IL-1β. Densitometry was measured by Quantity One 1-D analyze software (Universal Hood II; Bio-Rad Laboratories, Hercules, CA, USA). Values are presented as mean ± standard deviation, *P<0.05, compared to MPTP.

    Int J Mol Med, 2015, 36(5):1369-76.. Piperine purchased from Selleck.

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Biological Activity

Description Piperine (1-Piperoylpiperidine) is the alkaloid responsible for the pungency of black pepper and long pepper, which has also been used in some forms of traditional medicine and as an insecticide.
Targets
CYP3A4 [1]
In vitro

Piperine (1-Piperoylpiperidine) is the alkaloid responsible for the pungency of black pepper and long pepper, along with chavicine (an isomer of piperine). It has also been used in some forms of traditional medicine and as an insecticide. Piperine has been found to inhibit human CYP3A4 and P-glycoprotein, enzymes important for the metabolism and transport of xenobiotics and metabolites. [1] Piperine is found to be cytotoxic towards DLA and EAC cells at a concentration of 250 μ g/ml. Piperine (1.14 mg/dose/animal) could inhibit the solid tumor development in mice induced with DLA cells and increase the life span of mice bearing Ehrlich ascites carcinoma tumor. [2]

In vivo LD50: Mice 15.1mg/kg (i.v.), 43mg/kg (i.p.), 200mg/kg (s.c.), 330mg/kg (i.g.); Rats 33.5mg/kg (i.p.), 514mg/kg (i.g.) [3]

Protocol

Solubility (25°C)

In vitro DMSO 57 mg/mL (199.76 mM)
Ethanol 57 mg/mL (199.76 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 285.34
Formula

C17H19NO3

CAS No. 94-62-2
Storage powder
in solvent
Synonyms 1-Piperoylpiperidine

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02598726 Recruiting Bladder Spasm|Malignant Neoplasm|Pain|Urinary Urgency Mayo Clinic|National Cancer Institute (NCI) March 1 2016 Phase 1
NCT02598726 Recruiting Bladder Spasm|Malignant Neoplasm|Pain|Urinary Urgency Mayo Clinic|National Cancer Institute (NCI) March 1 2016 Phase 1
NCT01893424 Completed Pain Hadassah Medical Organization August 2013 Phase 1
NCT01893424 Completed Pain Hadassah Medical Organization August 2013 Phase 1
NCT01383694 Completed Deglutition Disorders Hospital de Mataró June 2011 Phase 1|Phase 2
NCT01383694 Completed Deglutition Disorders Hospital de Mataró June 2011 Phase 1|Phase 2

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P450 (e.g. CYP17) Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID