For research use only.
CAS No. 88495-63-0
Artesunate (WR-256283) is a part of the artemisinin group of agents with an IC50 of < 5 μM for small cell lung carcinoma cell line H69. It is a potential inhibitor of STAT-3 and exhibits selective cytotoxicity of cancer cells over normal cells in vitro; A potent inhibitor of EXP1.
Selleck's Artesunate (WR-256283) has been cited by 10 publications
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|Description||Artesunate (WR-256283) is a part of the artemisinin group of agents with an IC50 of < 5 μM for small cell lung carcinoma cell line H69. It is a potential inhibitor of STAT-3 and exhibits selective cytotoxicity of cancer cells over normal cells in vitro; A potent inhibitor of EXP1.|
ART could alter the biomechanical properties of the glioma cells to inhibit cell proliferation, migration and invasion . The ART significantly suppresses the cell proliferation, induces the apoptosis and promoted cell cycle arrest at G0/G1 phase in SKM-1 cells. The mechanisms of ART anti-MDS is associated with the increase of intracellular calciumion concentration and ROS levels. In addition, the pro-apoptotic activity of ART may be involved in the regulation of BCL-2 /BAX ratio and the expressions of P-bad and survivin. ART treatment demethylates CDH1, which, in turn recovers the E-cadherin activation in SKM-1 cells.
|In vivo||Artesunate is a medication used to treat malaria. Artesunate can induce radiosensitivity of HeLa cells in vivo using Xenograft model of nude mice. Artesunate had a relatively high immunosuppressive activity with low toxicity, and could inhibit T lymphocyte proliferation induced by mitogen and alloantigen.|
-  Xu N, et al. Int J Med Sci. 2015, 12(6):524-529.
-  Lian S, et al. Oncol Rep. 2016, 36(2):984-990.
-  Qiao SK, et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2016, 24(1):131-137.
|In vitro||DMSO||77 mg/mL (200.3 mM)|
|Ethanol||77 mg/mL (200.3 mM)|
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|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
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|% DMSO % % Tween 80 % ddH2O|
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Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT04921930||Not yet recruiting||Drug: Artesunate Oral Product||Friedreich Ataxia||Institut National de la Santé Et de la Recherche Médicale France|Imagine Institute||July 1 2021||Phase 1|Phase 2|
|NCT03893097||Completed||Drug: Praziquantel|Drug: Artesunate + Mefloquine||Schistosoma Haematobium|Schistosoma Mansoni||Institute of Tropical Medicine Belgium|Institut de Recherche en Santé de Surveillance Épidémiologique et de Formation (IRESSEF)||October 14 2019||Phase 3|
|NCT03792516||Recruiting||Drug: artesunate ointment 40%||Vulvar Dysplasia|HPV-Related Vulvar Intraepithelial Neoplasia|Preinvasive Vulvar Disease|Vulva Intraepithelial Neoplasia|Vulvar Diseases||Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins|Frantz Viral Therapeutics LLC||April 17 2019||Phase 1|
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